Involvement of orexin-A neurons but not melanin-concentrating hormone neurons in the short-term regulation of food intake in rats

Journal of Physiological Sciences

Volumn 64, Issue 3, 2014, Pages 203-211

  Nishimura, Yuri ^a   Mabuchi, Kaori ^a   Taguchi, Sayumi ^a   Ikeda, Saori ^a   Aida, Eri ^a   Negishi, Hiroko ^a   Takamata, Akira ^a  

^a NARA WOMEN'S UNIVERSITY   (Japan)

Author keywords

Feeding behavior; Glucoprivation; Glucosensitive neurons; Hypoglycemia; Melanin concentrating hormone; Orexin

Indexed keywords

DEOXYGLUCOSE; GLUCOSE BLOOD LEVEL; HYPOPHYSIS HORMONE; HYPOTHALAMUS HORMONE; INSULIN; MELANIN; MELANIN-CONCENTRATING HORMONE; NEUROPEPTIDE; OREXINS; PROTEIN C FOS; SIGNAL PEPTIDE;

ANIMAL; CHEMICALLY INDUCED; COMPARATIVE STUDY; DISEASE MODEL; DRUG EFFECTS; EATING; ENERGY METABOLISM; FEEDING BEHAVIOR; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; HYPOTHALAMUS; MALE; METABOLISM; NERVE CELL; PSYCHOLOGY; THERMOREGULATION; TIME; WISTAR RAT;

ANIMALS; BLOOD GLUCOSE; BODY TEMPERATURE REGULATION; DEOXYGLUCOSE; DISEASE MODELS, ANIMAL; EATING; ENERGY METABOLISM; FEEDING BEHAVIOR; HYPERGLYCEMIA; HYPOTHALAMIC HORMONES; HYPOTHALAMUS; INSULIN; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MELANINS; NEURONS; NEUROPEPTIDES; PITUITARY HORMONES; PROTO-ONCOGENE PROTEINS C-FOS; RATS, WISTAR; TIME FACTORS;

EID: 84901823345     PISSN: 18806546     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12576-014-0312-0     Document Type: Article

References (31)

1. Karnani M, Burdakov D (2011) Multiple hypothalamic circuits sense and regulate glucose levels. Am J Physiol Regul Integr Comp Physiol 300:R47-R55
2. Levin BE (2006) Metabolic sensing neurons and the control of energy homeostasis. Physiol Behav 89:486-489
3. Williams G, Cai XJ, Elliott JC, Harrold JA (2004) Anabolic neuropeptides. Physiol Behav 81:211-222
4. Schwartz MW, Woods SC, Porte D Jr, Seeley RJ, Baskin DG (2000) Central nervous system control of food intake. Nature 404:661-671
5. Leibowitz SF, Wortley KE (2004) Hypothalamic control of energy balance: different peptides, different functions. Peptides 25:473-504
6. Sakurai T (1999) Orexins and orexin receptors: implication in feeding behavior. Regul Pept 85:25-30
7. Bayer L, Mairet-Coello G, Risold P-Y, Griffond B (2002) Orexin/hypocretin neurons: chemical phenotype and possible interactions with melanin- concentrating hormone neurons. Regul Pept 104:33-39
8. Guyon A, Conductier G, Rovere C, Enfissi A, Nahon J-L (2009) Melanin-concentrating hormone producing neurons: activities and modulations. Peptides 30:2031-2039
9. Sergeyev V, Broberger C, Gorbatyuk O, Hökfelt T (2000) Effect of 2-mercaptoacetate and 2-deoxy-d-glucose administration on the expression of NPY, AGRP, POMC, MCH and hypocretin/orexin in the rat hypothalamus. Neuro Rep 11:117-121
10. Briski KP, Sylvester PW (2001) Hypothalamic orexin-A-immunopositive neurons express Fos in response to central glucopenia. Neuro Rep 12:531-534
11. Griffond B, Risold PY, Jacquemard C et al (1999) Insulin-induced hypoglycemia increases preprohypocretin (orexin) mRNA in the rat lateral hypothalamic area. Neurosci Lett 262:77-80
12. Moriguchi T, Sakurai T, Nambu T, Yanagisawa M, Goto K (1999) Neurons containing orexin in the lateral hypothalamic area of the adult rat brain are activated by insulin-induced acute hypoglycemia. Neurosci Lett 264:101-104
13. Cai XJ, Evans ML, Lister CA, Leslie RA, Arch JRS, Wilson S, Williams G (2001) Hypoglycemia activates orexin neurons and selectively increases hypothalamic orexin-B levels: responses inhibited by feeding and possibly mediated by the nucleus of the solitary tract. Diabetes 50:105-112
14. Zhou L, Yueh C-Y, Lam DD, Shaw J, Osundiji M, Garfield AS, Evans M, Heisler LK (2011) Glucokinase inhibitor glucosamine stimulates feeding and activates hypothalamic neuropeptide Y and orexin neurons. Behav Brain Res 222:274-278
15. Bayer L, Poncet F, Fellmann D, Griffond B (1999) Melanin-concentrating hormone expression in slice cultures of rat hypothalamus is not affected by 2-deoxyglucose. Neurosci Lett 267:77-80
16. Mogi K, Funabashi T, Mitsushima D, Hagiwara H, Kimura F (2005) Sex difference in the response of melanin-concentrating hormone neurons in the lateral hypothalamic area to glucose, as revealed by the expression of phosphorylated cyclic adenosine 3, "5-"monophosphate response element-binding protein. Endocrinology 146:3325-3333
17. Qu D, Ludwig DS, Gammeltoft S, Piper M, Pelleymounter MA, Cullen MJ, Mathes WF, Przypek R, Kanarek R, Maratos-Flier E (1996) A role for melanin-concentrating hormone in the central regulation of feeding behaviour. Nature 380:243-247
18. Yoshimura M, Hagimoto M, Matsuura T, Ohkubo J, Ohno M, Maruyama T, Ishikura T, Hashimoto H, Kakuma T, Yoshimatsu H, Terawaki K, Uezono Y, Toyohira Y, Yanagihara N, Ueta Y (2014) Effects of food deprivation on the hypothalamic feeding-regulating peptides gene expressions in serotonin depleted rats. J Physiol Sci 64:97-104
19. Bahjaoui-Bouhaddi M, Fellmann D, Griffond B, Bugnon C (1994) Insulin treatment stimulates the rat melanin-concentrating hormone-producing neurons. Neuropeptides 27:251-258
20. Hoffman GE, Smith MS, Verbalis JG (1993) c-Fos and related immediate early gene products as markers of activity in neuroendocrine systems. Front Neuroendocrinol 14:173-213
21. Kovács KJ (2008) Measurement of immediate-early gene activation-c-fos and beyond. J Neuroendocrinol 20:665-672
22. Paxinos G, Watson C (2004) The rat brain in stereotaxic coordinates, 4th edn. Academic Press, San Diego
23. Burdakov D, Gerasimenko O, Verkhratsky A (2005) Physiological changes in glucose differentially modulate the excitability of hypothalamic melanin-concentrating hormone and orexin neurons in situ. J Neurosci 25:2429-2433
24. Funabashi T, Hagiwara H, Mogi K, Mitsushima D, Shinohara K, Kimura F (2009) Sex differences in the responses of orexin neurons in the lateral hypothalamic area and feeding behavior to fasting. Neurosci Lett 463:31-34
25. Shiraishi T, Mager M (1980) 2-deoxy-d-glucose-induced hypothermia: thermoregulatory pathways in rat. Am J Physiol 239:R270-R276
26. Fiorentini A, Müller EE (1975) Sensitivity of central chemoreceptors controlling blood glucose and body temperature during glucose deprivation. J Physiol Lond 248:247-271
27. Elias CF, Aschkenasi C, Lee C, Kelly J, Ahima RS, Bjorbaek C, Flier JS, Saper CB, Elmquist JK (1999) Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. Neuron 23:775-786
28. Niimi M, Sato M, Taminato T (2001) Neuropeptide Y in central control of feeding and interactions with orexin and leptin. Endocrine 14:269-273
29. Sahu A (2002) Interactions of neuropeptide Y, hypocretin-I (orexin-A) and melanin-concentrating hormone on feeding in rats. Brain Res 944:232-238
30. Luquet S, Phillips CT, Palmiter RD (2007) NPY/AgRP neurons are not essential for feeding responses to glucoprivation. Peptides 28:214-225
31. Pardini AW, Nguyen HT, Figlewicz DP, Baskin DG, Williams DL, Kim F, Schwartz MW (2006) Distribution of insulin receptor substrate-2 in brain areas involved in energy homeostasis. Brain Res 1112:169-178