Natural progression of low-gradient severe aortic stenosis with preserved ejection fraction

Texas Heart Institute Journal

Volumn 41, Issue 3, 2014, Pages 273-279

  Innasimuthu, Antony Leslie ^a   Kumar, Sanjay ^a   Lazar, Jason ^a   Katz, William E ^b  

^a SUNY DOWNSTATE MEDICAL CENTER   (United States)

^b UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

Aortic valve stenosis; Blood flow velocity; Calcinosis complications; Disease progression; Echocardiography; Forecasting; Prognosis; Retrospective studies; Risk assessment; Stroke volume; Time factors; Ventricular function, left

Indexed keywords

AGED; AORTA STENOSIS; AORTA VALVE; ARTICLE; CORONARY ARTERY DISEASE; DISEASE COURSE; DISEASE SEVERITY; FEMALE; HEART FAILURE WITH PRESERVED EJECTION FRACTION; HEART INFARCTION; HEART LEFT VENTRICLE EJECTION FRACTION; HUMAN; MAJOR CLINICAL STUDY; MALE; PREVALENCE; RETROSPECTIVE STUDY; RISK ASSESSMENT; SCORING SYSTEM; SURVIVAL RATE; TRANSTHORACIC ECHOCARDIOGRAPHY; VERY ELDERLY; AORTA VALVE STENOSIS; COMPARATIVE STUDY; ECHOGRAPHY; HEART LEFT VENTRICLE FUNCTION; HEART STROKE VOLUME; HEMODYNAMICS; MIDDLE AGED; PATHOPHYSIOLOGY; SEVERITY OF ILLNESS INDEX; TIME;

AGED; AGED, 80 AND OVER; AORTIC VALVE; AORTIC VALVE STENOSIS; DISEASE PROGRESSION; FEMALE; HEMODYNAMICS; HUMANS; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; STROKE VOLUME; TIME FACTORS; VENTRICULAR FUNCTION, LEFT;

EID: 84901804328     PISSN: 07302347     EISSN: 15266702     Source Type: Journal    
DOI: 10.14503/THIJ-13-3167     Document Type: Article

References (35)

1. Rajamannan NM, Bonow RO, Rahimtoola SH. Calcific aortic stenosis: an update. Nat Clin Pract Cardiovasc Med 2007; 4(5):254-62.
2. Stewart BF, Siscovick D, Lind BK, Gardin JM, Gottdiener JS, Smith VE, et al. Clinical factors associated with calcific aortic valve disease. Cardiovascular Health Study. J Am Coll Cardiol 1997;29(3):630-4.
3. Otto CM. Aortic stenosis. Clinical evaluation and optimal timing of surgery. Cardiol Clin 1998;16(3):353-73, vii.
4. Otto CM, Lind BK, Kitzman DW, Gersh BJ, Siscovick DS. Association of aortic-valve sclerosis with cardiovascular mortality and morbidity in the elderly. N Engl J Med 1999; 341(3):142-7.
5. Otto CM, Burwash IG, Legget ME, Munt BI, Fujioka M, Healy NL, et al. Prospective study of asymptomatic valvular aortic stenosis. Clinical, echocardiographic, and exercise predictors of outcome. Circulation 1997;95(9):2262-70.
6. Pellikka PA, Sarano ME, Nishimura RA, Malouf JF, Bailey KR, Scott CG, et al. Outcome of 622 adults with asymptomatic, hemodynamically significant aortic stenosis during prolonged follow-up. Circulation 2005;111(24):3290-5.
7. Rosenhek R, Binder T, Porenta G, Lang I, Christ G, Schemper M, et al. Predictors of outcome in severe, asymptomatic aortic stenosis. N Engl J Med 2000;343(9):611-7.
8. American College of Cardiology; American Heart Association Task Force on Practice Guidelines (Writing Committee to revise the 1998 guidelines for the management of patients with valvular heart disease); Society of Cardiovascular Anesthesiologists; Bonow RO, Carabello BA, Chatterjee K, et al. ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to revise the 1998 guidelines for the management of patients with valvular heart disease) developed in collaboration with the Society of Cardiovascular Anesthesiologists endorsed by the Society for Cardiovascular Angiography and Interventions and the Society of Thoracic Surgeons [published erratum appears in J Am Coll Cardiol 2007;49(9):1014]. J Am Coll Cardiol 2006;48(3):e1-148.
9. Aikawa K, Otto CM. Timing of surgery in aortic stenosis. Prog Cardiovasc Dis 2001;43(6):477-93.
10. Vahanian A, Baumgartner H, Bax J, Butchart E, Dion R, Filippatos G, et al. Guidelines on the management of valvular heart disease: The Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology. Eur Heart J 2007;28(2):230-68.
11. Minners J, Allgeier M, Gohlke-Baerwolf C, Kienzle RP, Neumann FJ, Jander N. Inconsistencies of echocardiographic criteria for the grading of aortic valve stenosis. Eur Heart J 2008;29(8):1043-8.
12. Minners J, Allgeier M, Gohlke-Baerwolf C, Kienzle RP, Neumann FJ, Jander N. Inconsistent grading of aortic valve stenosis by current guidelines: haemodynamic studies in patients with apparently normal left ventricular function. Heart 2010; 96(18):1463-8.
13. Adda J, Mielot C, Giorgi R, Cransac F, Zirphile X, Donal E, et al. Low-flow, low-gradient severe aortic stenosis despite normal ejection fraction is associated with severe left ventricular dysfunction as assessed by speckle-tracking echocardiography: a multicenter study. Circ Cardiovasc Imaging 2012;5(1):27-35.
14. Barboza J, Krishnan N, Ananthasubramaniam K. Clinical challenges in accurate assessment of severe aortic stenosis with a special focus on low-gradient aortic stenosis and normal ejection fraction. Cardiol Rev 2011;19(5):239-45.
15. Belkin RN, Khalique O, Aronow WS, Ahn C, Sharma M. Outcomes and survival with aortic valve replacement compared with medical therapy in patients with low-, moderate-,and severe-gradient severe aortic stenosis and normal left ventricular ejection fraction. Echocardiography 2011;28(4):378-87.
16. Pibarot P, Dumesnil JG. Low-flow, low-gradient, normal ejection fraction aortic stenosis. Curr Cardiol Rep 2010;12(2): 108-15.
17. Pai RG, Varadarajan P, Razzouk A. Survival benefit of aortic valve replacement in patients with severe aortic stenosis with low ejection fraction and low gradient with normal ejection fraction. Ann Thorac Surg 2008;86(6):1781-9.
18. Clavel MA, Fuchs C, Burwash IG, Mundigler G, Dumesnil JG, Baumgartner H, et al. Predictors of outcomes in low-flow, low-gradient aortic stenosis: results of the multicenter TOPAS Study. Circulation 2008;118(14 Suppl):S234-42.
19. Levy F, Laurent M, Monin JL, Maillet JM, Pasquet A, Le Tourneau T, et al. Aortic valve replacement for low-f low/low-gradient aortic stenosis operative risk stratification and long-term outcome: a European multicenter study. J Am Coll Cardiol 2008;51(15):1466-72.
20. Hachicha Z, Dumesnil JG, Bogaty P, Pibarot P. Paradoxical low-flow, low-gradient severe aortic stenosis despite preserved ejection fraction is associated with higher afterload and reduced survival. Circulation 2007;115(22):2856-64.
21. Christensen KL, Ivarsen HR, Thuesen L, Kristensen BO, Egeblad H. Aortic valve stenosis: fatal natural history despite normal left ventricular function and low invasive peak-topeak pressure gradients. Cardiology 2004;102(3):147-51.
22. Burwash IG, Dickinson A, Teskey RJ, Tam JW, Chan KL. Aortic valve area discrepancy by Gorlin equation and Doppler echocardiography continuity equation: relationship to flow in patients with valvular aortic stenosis. Can J Cardiol 2000;16 (8):985-92.
23. Dumesnil JG, Pibarot P, Carabello B. Paradoxical low flow and/or low gradient severe aortic stenosis despite preserved left ventricular ejection fraction: implications for diagnosis and treatment. Eur Heart J 2010;31(3):281-9.
24. Jander N, Minners J, Holme I, Gerdts E, Boman K, Brudi P, et al. Outcome of patients with low-gradient "severe" aortic stenosis and preserved ejection fraction [published erratum appears in Circulation 2011;124(12):e336]. Circulation 2011; 123(8):887-95.
25. Doddamani S, Bello R, Friedman MA, Banerjee A, Bowers JH Jr, Kim B, et al. Demonstration of left ventricular outflow tract eccentricity by real time 3D echocardiography: implications for the determination of aortic valve area. Echocardiography 2007;24(8):860-6.
26. Skjaerpe T, Hegrenaes L, Hatle L. Noninvasive estimation of valve area in patients with aortic stenosis by Doppler ultrasound and two-dimensional echocardiography. Circulation 1985;72(4):810-8.
27. Otto CM, Pearlman AS, Gardner CL, Kraft CD, Fujioka MC. Simplification of the Doppler continuity equation for calculating stenotic aortic valve area. J Am Soc Echocardiogr 1988;1(2):155-7.
28. Teague SM, Heinsimer JA, Anderson JL, Sublett K, Olson EG, Voyles WF, Thadani U. Quantification of aortic regurgitation utilizing continuous wave Doppler ultrasound. J Am Coll Cardiol 1986;8(3):592-9.
29. Touche T, Prasquier R, Nitenberg A, de Zuttere D, Gourgon R. Assessment and follow-up of patients with aortic regurgitation by an updated Doppler echocardiographic measurement of the regurgitant fraction in the aortic arch. Circulation 1985;72(4):819-24.
30. Otto CM, Pearlman AS, Gardner CL. Hemodynamic progression of aortic stenosis in adults assessed by Doppler echocardiography. J Am Coll Cardiol 1989;13(3):545-50.
31. Peter M, Hoffmann A, Parker C, Luscher T, Burckhardt D. Progression of aortic stenosis. Role of age and concomitant coronary artery disease. Chest 1993;103(6):1715-9.
32. Ross J Jr, Braunwald E. Aortic stenosis. Circulation 1968;38(1 Suppl):61-7.
33. Baumgartner H, Kratzer H, Helmreich G, Kuehn P. Determination of aortic valve area by Doppler echocardiography using the continuity equation: a critical evaluation. Cardiology 1990;77(2):101-11.
34. Carabello BA. Clinical practice. Aortic stenosis. N Engl J Med 2002;346(9):677-82.
35. Kadem L, Dumesnil JG, Rieu R, Durand LG, Garcia D, Pibarot P. Impact of systemic hypertension on the assessment of aortic stenosis. Heart 2005;91(3):354-61.