MicroRNA-125b regulates osteogenic differentiation of mesenchymal stem cells by targeting Cbfβ in vitro

Biochimie

Volumn 102, Issue 1, 2014, Pages 47-55

  Huang, Ke ^a   Fu, Jingshu ^a   Zhou, Wei ^a   Li, Wei ^a   Dong, Shiwu ^a   Yu, Shengpeng ^a   Hu, Zongkai ^a   Wang, Huaqing ^a   Xie, Zhao ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

C3H10T1 2 cell; Cbf ; MiR 125b; Runx2

Indexed keywords

ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN 2; CBF BETA PROTEIN; MICRORNA 125B; OSTEOCALCIN; OSTEOPONTIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG; CBFB PROTEIN, MOUSE; CORE BINDING FACTOR BETA; MESSENGER RNA; MICRORNA; MIRN125 MICRORNA, MOUSE; RUNX2 PROTEIN, MOUSE;

3' UNTRANSLATED REGION; ANIMAL CELL; ARTICLE; BINDING SITE; BONE DEVELOPMENT; CELL DIFFERENTIATION; DOWN REGULATION; GENE EXPRESSION; IN VITRO STUDY; MARKER GENE; MESENCHYMAL STEM CELL; NONHUMAN; OSTEOBLAST; PROTEIN TARGETING; REGULATORY MECHANISM; REPORTER GENE; UPREGULATION; ANIMAL; BIOSYNTHESIS; CELL LINEAGE; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; MESENCHYMAL STROMA CELL; MICROBIOLOGY; MOUSE;

ANIMALS; BINDING SITES; CELL DIFFERENTIATION; CELL LINEAGE; CORE BINDING FACTOR ALPHA 1 SUBUNIT; CORE BINDING FACTOR BETA SUBUNIT; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MESENCHYMAL STROMAL CELLS; MICE; MICRORNAS; OSTEOGENESIS; RNA, MESSENGER;

EID: 84901804072     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2014.02.005     Document Type: Article

References (53)

1. P. Charbord Bone marrow mesenchymal stem cells: historical overview and concepts Hum. Gene. Ther. 21 2010 1045 1056
2. B. Sacchetti, A. Funari, S. Michienzi, S. Di Cesare, S. Piersanti, I. Saggio, E. Tagliafico, S. Ferrari, P.G. Robey, M. Riminucci, and P. Bianco Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment Cell 131 2007 324 336
3. M.F. Pittenger, A.M. Mackay, S.C. Beck, R.K. Jaiswal, R. Douglas, J.D. Mosca, M.A. Moorman, D.W. Simonetti, S. Craig, and D.R. Marshak Multilineage potential of adult human mesenchymal stem cells Science 284 1999 143 147
4. J. Sammons, N. Ahmed, M. El-Sheemy, and H.T. Hassan The role of BMP-6, IL-6, and BMP-4 in mesenchymal stem cell-dependent bone development: effects on osteoblastic differentiation induced by parathyroid hormone and vitamin D(3) Stem Cells Dev. 13 2004 273 280
5. H. Shimaoka, Y. Dohi, H. Ohgushi, M. Ikeuchi, M. Okamoto, A. Kudo, T. Kirita, and K. Yonemasu Recombinant growth/differentiation factor-5 (GDF-5) stimulates osteogenic differentiation of marrow mesenchymal stem cells in porous hydroxyapatite ceramic J. Biomed. Mater. Res. A 68 2004 168 176
6. E. Ogawa, M. Inuzuka, M. Maruyama, M. Satake, M. Naito-Fujimoto, Y. Ito, and K. Shigesada Molecular cloning and characterization of PEBP2 beta, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2 alpha Virology 194 1993 314 331
7. C.A. Yoshida, T. Furuichi, T. Fujita, R. Fukuyama, N. Kanatani, S. Kobayashi, M. Satake, K. Takada, and T. Komori Core-binding factor beta interacts with Runx2 and is required for skeletal development Nat. Genet. 32 2002 633 638
8. D.P. Bartel MicroRNAs: genomics, biogenesis, mechanism, and function Cell 116 2004 281 297
9. E.J. Lee, M. Baek, Y. Gusev, D.J. Brackett, G.J. Nuovo, and T.D. Schmittgen Systematic evaluation of microRNA processing patterns in tissues, cell lines, and tumors RNA 14 2008 35 42
10. B. Meder, H.A. Katus, and W. Rottbauer Right into the heart of microRNA-133a Genes Dev. 22 2008 3227 3231
11. F. Fazi, and C. Nervi MicroRNA: basic mechanisms and transcriptional regulatory networks for cell fate determination Cardiovasc. Res. 79 2008 553 561
12. K.M. Foshay, and G.I. Gallicano Small RNAs, big potential: the role of MicroRNAs in stem cell function Curr. Stem Cell Res. Ther. 2 2007 264 271
13. M.T. Le, H. Xie, B. Zhou, P.H. Chia, P. Rizk, M. Um, G. Udolph, H. Yang, B. Lim, and H.F. Lodish MicroRNA-125b promotes neuronal differentiation in human cells by repressing multiple targets Mol. Cell Biol. 29 2009 5290 5305
14. M.T. Le, C. Teh, N. Shyh-Chang, H. Xie, B. Zhou, V. Korzh, H.F. Lodish, and B. Lim MicroRNA-125b is a novel negative regulator of p53 Genes Dev. 23 2009 862 876
15. Y.S. Lee, H.K. Kim, S. Chung, K.S. Kim, and A. Dutta Depletion of human micro-RNA miR-125b reveals that it is critical for the proliferation of differentiated cells but not for the down-regulation of putative targets during differentiation J. Biol. Chem. 280 2005 16635 16641
16. M.V. Iorio, M. Ferracin, C.G. Liu, A. Veronese, R. Spizzo, S. Sabbioni, E. Magri, M. Pedriali, M. Fabbri, M. Campiglio, S. Menard, J.P. Palazzo, A. Rosenberg, P. Musiani, S. Volinia, I. Nenci, G.A. Calin, P. Querzoli, M. Negrini, and C.M. Croce MicroRNA gene expression deregulation in human breast cancer Cancer Res. 65 2005 7065 7070
17. R. Visone, P. Pallante, A. Vecchione, R. Cirombella, M. Ferracin, A. Ferraro, S. Volinia, S. Coluzzi, V. Leone, E. Borbone, C.G. Liu, F. Petrocca, G. Troncone, G.A. Calin, A. Scarpa, C. Colato, G. Tallini, M. Santoro, C.M. Croce, and A. Fusco Specific microRNAs are downregulated in human thyroid anaplastic carcinomas Oncogene 26 2007 7590 7595
18. G.K. Scott, A. Goga, D. Bhaumik, C.E. Berger, C.S. Sullivan, and C.C. Benz Coordinate suppression of ERBB2 and ERBB3 by enforced expression of micro-RNA miR-125a or miR-125b J. Biol. Chem. 282 2007 1479 1486
19. Y. Mizuno, K. Yagi, Y. Tokuzawa, Y. Kanesaki-Yatsuka, T. Suda, T. Katagiri, T. Fukuda, M. Maruyama, A. Okuda, T. Amemiya, Y. Kondoh, H. Tashiro, and Y. Okazaki miR-125b inhibits osteoblastic differentiation by down-regulation of cell proliferation Biochem. Biophys. Res. Commun. 368 2008 267 272
20. S. Dong, B. Yang, H. Guo, and F. Kang MicroRNAs regulate osteogenesis and chondrogenesis Biochem. Biophys. Res. Commun. 418 2012 587 591
21. B. Yang, H. Guo, Y. Zhang, S. Dong, and D. Ying The microRNA expression profiles of mouse mesenchymal stem cell during chondrogenic differentiation BMB Rep. 44 2011 28 33
22. B. Yang, H. Guo, Y. Zhang, L. Chen, D. Ying, and S. Dong MicroRNA-145 regulates chondrogenic differentiation of mesenchymal stem cells by targeting Sox9 PLoS One 6 2011 e21679
23. E.A. Lin, L. Kong, X.H. Bai, Y. Luan, and C.J. Liu miR-199a, a bone morphogenic protein 2-responsive MicroRNA, regulates chondrogenesis via direct targeting to Smad1 J. Biol. Chem. 284 2009 11326 11335
24. Y. Li, B. Zhang, C. Ruan, P. Wang, J. Sun, J. Pan, and Y. Wang Synthesis, characterization, and biocompatibility of a novel biomimetic material based on MGF-Ct24E modified poly(d,l-lactic acid) J. Biomed. Mater. Res. A 100 2012 3496 3502
25. S.R. Baglio, V. Devescovi, D. Granchi, and N. Baldini MicroRNA expression profiling of human bone marrow mesenchymal stem cells during osteogenic differentiation reveals Osterix regulation by miR-31 Gene 527 2013 321 331
26. A. Krek, D. Grun, M.N. Poy, R. Wolf, L. Rosenberg, E.J. Epstein, P. MacMenamin, I. da Piedade, K.C. Gunsalus, M. Stoffel, and N. Rajewsky Combinatorial microRNA target predictions Nat. Genet. 37 2005 495 500
27. B.P. Lewis, I.H. Shih, M.W. Jones-Rhoades, D.P. Bartel, and C.B. Burge Prediction of mammalian microRNA targets Cell 115 2003 787 798
28. M. Kato, and F.J. Slack microRNAs: small molecules with big roles - C. elegans to human cancer Biol. Cell 100 2008 71 81
29. Y.W. Kong, I.G. Cannell, C.H. de Moor, K. Hill, P.G. Garside, T.L. Hamilton, H.A. Meijer, H.C. Dobbyn, M. Stoneley, K.A. Spriggs, A.E. Willis, and M. Bushell The mechanism of micro-RNA-mediated translation repression is determined by the promoter of the target gene Proc. Natl. Acad. Sci. U. S. A. 105 2008 8866 8871
30. J. Wei, Y. Shi, L. Zheng, B. Zhou, H. Inose, J. Wang, X.E. Guo, R. Grosschedl, and G. Karsenty miR-34s inhibit osteoblast proliferation and differentiation in the mouse by targeting SATB2 J. Cell Biol. 197 2012 509 521
31. J.C. Carrington, and V. Ambros Role of microRNAs in plant and animal development Science 301 2003 336 338
32. J.G. Doench, C.P. Petersen, and P.A. Sharp siRNAs can function as miRNAs Genes Dev. 17 2003 438 442
33. Y. Zeng, R. Yi, and B.R. Cullen MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms Proc. Natl. Acad. Sci. U. S. A. 100 2003 9779 9784
34. M. Kundu, A. Chen, S. Anderson, M. Kirby, L. Xu, L.H. Castilla, D. Bodine, and P.P. Liu Role of Cbfb in hematopoiesis and perturbations resulting from expression of the leukemogenic fusion gene Cbfb-MYH11 Blood 100 2002 2449 2456
35. S.M. Hart, and L. Foroni Core binding factor genes and human leukemia Haematologica 87 2002 1307 1323
36. L. Talebian, Z. Li, Y. Guo, J. Gaudet, M.E. Speck, D. Sugiyama, P. Kaur, W.S. Pear, I. Maillard, and N.A. Speck T-lymphoid, megakaryocyte, and granulocyte development are sensitive to decreases in CBFbeta dosage Blood 109 2007 11 21
37. K.Y. Lin, X.J. Zhang, D.D. Feng, H. Zhang, C.W. Zeng, B.W. Han, A.D. Zhou, L.H. Qu, L. Xu, and Y.Q. Chen miR-125b, a target of CDX2, regulates cell differentiation through repression of the core binding factor in hematopoietic malignancies J. Biol. Chem. 286 2011 38253 38263
38. X. Li, Y. Zhang, H. Zhang, X. Liu, T. Gong, M. Li, L. Sun, G. Ji, Y. Shi, Z. Han, S. Han, Y. Nie, X. Chen, Q. Zhao, J. Ding, K. Wu, and F. Daiming miRNA-223 promotes gastric cancer invasion and metastasis by targeting tumor suppressor EPB41L3 Mol. Cancer Res. 9 2011 824 833
39. T. Komori, H. Yagi, S. Nomura, A. Yamaguchi, K. Sasaki, K. Deguchi, Y. Shimizu, R.T. Bronson, Y.H. Gao, M. Inada, M. Sato, R. Okamoto, Y. Kitamura, S. Yoshiki, and T. Kishimoto Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts Cell 89 1997 755 764
40. F. Otto, A.P. Thornell, T. Crompton, A. Denzel, K.C. Gilmour, I.R. Rosewell, G.W. Stamp, R.S. Beddington, S. Mundlos, B.R. Olsen, P.B. Selby, and M.J. Owen Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development Cell 89 1997 765 771
41. T. Okuda, J. van Deursen, S.W. Hiebert, G. Grosveld, and J.R. Downing AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis Cell 84 1996 321 330
42. Q. Wang, T. Stacy, M. Binder, M. Marin-Padilla, A.H. Sharpe, and N.A. Speck Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis Proc. Natl. Acad. Sci. U. S. A. 93 1996 3444 3449
43. Q.L. Li, K. Ito, C. Sakakura, H. Fukamachi, K. Inoue, X.Z. Chi, K.Y. Lee, S. Nomura, C.W. Lee, S.B. Han, H.M. Kim, W.J. Kim, H. Yamamoto, N. Yamashita, T. Yano, T. Ikeda, S. Itohara, J. Inazawa, T. Abe, A. Hagiwara, H. Yamagishi, A. Ooe, A. Kaneda, T. Sugimura, T. Ushijima, S.C. Bae, and Y. Ito Causal relationship between the loss of RUNX3 expression and gastric cancer Cell 109 2002 113 124
44. T. Komori Requisite roles of Runx2 and Cbfb in skeletal development J. Bone Miner. Metab. 21 2003 193 197
45. V.K. Gangaraju, and H. Lin MicroRNAs: key regulators of stem cells Nat. Rev. Mol. Cell Biol. 10 2009 116 125
46. U. Lakshmipathy, and R.P. Hart Concise review: microRNA expression in multipotent mesenchymal stromal cells Stem Cells 26 2008 356 363
47. J. Huang, L. Zhao, L. Xing, and D. Chen MicroRNA-204 regulates Runx2 protein expression and mesenchymal progenitor cell differentiation Stem Cells 28 2010 357 364
48. Y. Guan, H. Yao, Z. Zheng, G. Qiu, and K. Sun MiR-125b targets BCL3 and suppresses ovarian cancer proliferation Int. J. Cancer 128 2011 2274 2283
49. L. Huang, J. Luo, Q. Cai, Q. Pan, H. Zeng, Z. Guo, W. Dong, J. Huang, and T. Lin MicroRNA-125b suppresses the development of bladder cancer by targeting E2F3 Int. J. Cancer 128 2011 1758 1769
50. N. Xu, P. Brodin, T. Wei, F. Meisgen, L. Eidsmo, N. Nagy, L. Kemeny, M. Stahle, E. Sonkoly, and A. Pivarcsi MiR-125b, a microRNA downregulated in psoriasis, modulates keratinocyte proliferation by targeting FGFR2 J. Invest. Dermatol. 131 2011 1521 1529
51. Y. Deng, S. Wu, H. Zhou, X. Bi, Y. Wang, Y. Hu, P. Gu, and X. Fan Effects of a miR-31, Runx2, and Satb2 regulatory loop on the osteogenic differentiation of bone mesenchymal stem cells Stem Cells Dev. 22 2013 2278 2286
52. Y. Deng, H. Zhou, D. Zou, Q. Xie, X. Bi, P. Gu, and X. Fan The role of miR-31-modified adipose tissue-derived stem cells in repairing rat critical-sized calvarial defects Biomaterials 34 2013 6717 6728
53. X. Lu, M. Deng, H. He, D. Zeng, and W. Zhang [miR-125b regulates osteogenic differentiation of human bone marrow mesenchymal stem cells by targeting Smad4] Zhong Nan Da Xue Xue Bao Yi Xue Ban 38 2013 341 346