Age at diagnosis and distant metastasis in breast cancer - A surprising inverse relationship

European Journal of Cancer

Volumn 50, Issue 10, 2014, Pages 1697-1705

  Purushotham, A ^a,b   Shamil, E ^a   Cariati, M ^a,b   Agbaje, O ^a   Muhidin, A ^a   Gillett, C ^a   Mera, A ^a   Sivanadiyan, K ^a   Harries, M ^a,b   Sullivan, R ^a   Pinder, S E ^a,b   Garmo, H ^a   Holmberg, L ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Age; Breast cancer; Distant metastasis; Relationship

Indexed keywords

ESTROGEN RECEPTOR; GAMMA UROGASTRONE; PROGESTERONE RECEPTOR;

ADULT; AGED; ARTICLE; AXILLARY LYMPH NODE; BONE METASTASIS; BREAST CANCER; BREAST CARCINOMA; BREAST METASTASIS; CANCER LOCALIZATION; CANCER MORTALITY; CANCER RISK; CANCER SIZE; CANCER SURVIVAL; CLINICAL FEATURE; DISTANT METASTASIS; FEMALE; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; METASTASIS FREE SURVIVAL; OVERALL SURVIVAL; PRIORITY JOURNAL; VISCERAL METASTASIS;

AGE; BREAST CANCER; DISTANT METASTASIS; RELATIONSHIP;

ADULT; AGE FACTORS; AGED; BONE NEOPLASMS; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; CARCINOMA, LOBULAR; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; LYMPHATIC METASTASIS; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEOPLASM GRADING; NEOPLASM INVASIVENESS; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, ESTROGEN; RECEPTORS, PROGESTERONE; REGISTRIES; RISK FACTORS; TIME FACTORS; TREATMENT OUTCOME; TUMOR BURDEN; TUMOR MARKERS, BIOLOGICAL;

EID: 84901777596     PISSN: 09598049     EISSN: 18790852     Source Type: Journal    
DOI: 10.1016/j.ejca.2014.04.002     Document Type: Article

References (20)

1. S. Paget The distribution of secondary growths in cancer of the breast Lancet 1 1889 571
2. D.X. Nguyen, P.D. Bos, and J. Massagué Metastasis: from dissemination to organ-specific colonization Nat Rev Cancer 9 2009 274 284
3. U. Woelfle, J. Cloos, and G. Sauter et al. Molecular signature associated with bone marrow micrometastasis in human breast cancer Cancer Res 63 18 2003 5679 5684
4. X.H. Zhang, Q. Wang, and W. Gerald et al. Latent bone metastasis in breast cancer tied to Src-dependent survival signals Cancer Cell 16 1 2009 67 78
5. R. Sanz, R. Aragüés, and V. Stresing et al. Functional pathways shared by liver and lung metastases: a mitochondrial chaperone machine is up-regulated in soft-tissue breast cancer metastasis Clin Exp Metastasis 24 8 2007 673 683
6. D.L. Kalbfleisch, and R.L. Prentice The statistical analysis of failure time data 2nd ed. 2002 John Wiley New York
7. R. Ihaka, and R. Gentleman A language for data analysis and graphics J Comput Graph Stat 5 1996 299 314
8. M. Harris, A. Howell, M. Chrissohou, R.I. Swindell, M. Hudson, and R.A. Sellwood A comparison of the metastatic pattern of infiltrating lobular carcinoma and infiltrating duct carcinoma of the breast Br J Cancer 50 1 1984 23 30
9. S.G. Ahn, H.M. Lee, S.H. Cho, S.A. Lee, S.H. Hwang, and J. Jeong et al. Prognostic factors for patients with bone-only metastasis in breast cancer Yonsei Med J 54 5 2013 1168 1177 10.3349/ymj.2013.54.5.1168
10. P.J. Linton, L. Haynes, L. Tsui, X. Zhang, and S. Swain From naive to effector-alterations with aging Immunol Rev 160 1997 9 18
11. R.D. Stout, and J. Suttles Immunosenescence and macrophage functional plasticity: dysregulation of macrophage function by age-associated microenvironmental changes Immunol Rev 205 2005 60 71
12. N. McCarthy Metastasis: influencing bad behaviour Nat Rev Cancer 9 2009 609 10.1038/nrc2720
13. T.R. Cox, and J.T. Erler Remodelling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer Dis Model Mech 4 2 2011 165 178 10.1242/dmm.004077 Epub 2011 Feb 14
14. R. Pili, Y. Guo, J. Chang, H. Nakanishi, G.R. Martin, and A. Passaniti Altered angiogenesis underlying age-dependent changes in tumor growth J Natl Cancer Inst 86 17 1994 1303 1314
15. R.A. Kreisle, B.A. Stebler, and W.B. Ershler Effect of host age on tumor-associated angiogenesis in mice J Natl Cancer Inst 82 1 1990 44 47
16. R. Hirayama, K. Takemura, Z. Nihei, W. Ichikawa, Y. Takagi, and Y. Mishima et al. Differential effect of host microenvironment and systemic humoral factors on the implantation and the growth rate of metastatic tumor in parabiotic mice constructed between young and old mice Mech Ageing Dev 71 3 1993 213 221
17. M.E. Weksler, T. Tsuda, Y.T. Kim, and G.W. Siskind Immunobiology of aging and cancer Cancer Detect Prev 14 6 1990 609 611
18. H. Møller, F. Sandin, F. Bray, A. Klint, K.M. Linklater, and A. Purushotham et al. Breast cancer survival in England, Norway and Sweden: a population-based comparison Int J Cancer 127 11 2010 2630 2638
19. S. Eaker, P.W. Dickman, L. Bergkvist, and L. Holmberg The Uppsala/Orebro breast cancer group differences in management of older women influence breast cancer survival: results from a population-based database in Sweden PLoS Med 3 2006 321 328
20. C. Stapelkamp, L. Holmberg, D. Tataru, H. Møller, and D. Robinson Predictors of early death in female patients with breast cancer in the UK: a cohort study BMJ Open 1 2 2011 e000247 10.1136/bmjopen-2011-000247 Print 2011