Age-related homeostatic midchannel proteolysis of neuronal L-type voltage-gated Ca2+ channels

Neuron

Volumn 82, Issue 5, 2014, Pages 1045-1057

  Michailidis, Ioannis E ^a   Abele Henckels, Kathryn ^a   Zhang, Wei K ^a   Lin, Bochao ^a   Yu, Yong ^a   Geyman, Lawrence S ^a   Ehlers, Michael D ^b   Pnevmatikakis, Eftychios A ^a   Yang, Jian ^a,c  

^a Department of Biological Sciences Columbia University ^*  (United States)

^b PFIZER INC   (United States)

^c KUNMING INSTITUTE OF ZOOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL L TYPE; CALPAIN; PROTEASOME; UBIQUITIN; VOLTAGE GATED CALCIUM CHANNEL;

AGE; AGED; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM CURRENT; CALCIUM TRANSPORT; CELL DIVISION; CELL MEMBRANE; CHANNEL GATING; CONTROLLED STUDY; ENZYME ACTIVITY; HOMEOSTASIS; MALE; MIDCHANNEL PROTEOLYSIS; NERVE CELL; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT;

AGE FACTORS; ANIMALS; CALCIUM; CALCIUM CHANNELS, L-TYPE; CEREBRAL CORTEX; FEMALE; HIPPOCAMPUS; HOMEOSTASIS; MALE; NEURONS; PROTEOLYSIS; RATS; XENOPUS;

EID: 84901756952     PISSN: 08966273     EISSN: 10974199     Source Type: Journal    
DOI: 10.1016/j.neuron.2014.04.017     Document Type: Article

References (54)

1. vβ subunit prevents RFP2-mediated ubiquitination and proteasomal degradation of L-type channels. Nat. Neurosci. 2011, 14:173-180.
2. Blanpied T.A., Scott D.B., Ehlers M.D. Dynamics and regulation of clathrin coats at specialized endocytic zones of dendrites and spines. Neuron 2002, 36:435-449.
3. 1 subunit of the skeletal muscle dihydropyridine-sensitive calcium channel. J.Biol. Chem. 1992, 267:18218-18223.
4. Cain S.M., Snutch T.P. Voltage-gated calcium channels and disease. Biofactors 2011, 37:197-205.
5. vα1 protein stability. J.Cell Biol. 2009, 184:923-933.
6. 2+ channels. Annu. Rev. Cell Dev. Biol. 2000, 16:521-555.
7. Chaitanya G.V., Steven A.J., Babu P.P. PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration. Cell Commun. Signal. 2010, 8:31.
8. 2+ channels. Biochim. Biophys. Acta 2012, 1820:1243-1252.
9. Deisseroth K., Mermelstein P.G., Xia H., Tsien R.W. Signaling from synapse to nucleus: the logic behind the mechanisms. Curr. Opin. Neurobiol. 2003, 13:354-365.
10. 1 subunit of skeletal muscle L-type calcium channels. Proc. Natl. Acad. Sci. USA 1991, 88:10778-10782.
11. 1 subunit by calpain. J.Neurochem. 1994, 63:1558-1564.
12. V1.2 calcium channels in hippocampal neurons. J.Neurosci. 2011, 31:13682-13694.
13. Dolmetsch R. Excitation-transcription coupling: signaling by ion channels to the nucleus. Sci. STKE 2003, 2003:PE4.
14. Ebihara T., Komiya Y., Izumi-Nakaseko H., Adachi-Akahane S., Okabe S., Okamura Y. Coexpression of a Ca(v)1.2 protein lacking an N-terminus and the first domain specifically suppresses L-type calcium channel activity. FEBS Lett. 2002, 529:203-207.
15. Fuller M.D., Emrick M.A., Sadilek M., Scheuer T., Catterall W.A. Molecular mechanism of calcium channel regulation in the fight-or-flight response. Sci. Signal. 2010, 3:ra70.
16. V1.2) subunit associate with and regulate L-type calcium channels containing C-terminal-truncated α1C subunits. J.Biol. Chem. 2001, 276:21089-21097.
17. Gerhardstein B.L., Gao T., Bünemann M., Puri T.S., Adair A., Ma H., Hosey M.M. Proteolytic processing of the C terminus of the α(1C) subunit of L-type calcium channels and the role of a proline-rich domain in membrane tethering of proteolytic fragments. J.Biol. Chem. 2000, 275:8556-8563.
18. Hell J.W., Yokoyama C.T., Wong S.T., Warner C., Snutch T.P., Catterall W.A. Differential phosphorylation of two size forms of the neuronal class C L-type calcium channel α1 subunit. J.Biol. Chem. 1993, 268:19451-19457.
19. Hell J.W., Westenbroek R.E., Breeze L.J., Wang K.K., Chavkin C., Catterall W.A. N-methyl-D-aspartate receptor-induced proteolytic conversion of postsynaptic class C L-type calcium channels in hippocampal neurons. Proc. Natl. Acad. Sci. USA 1996, 93:3362-3367.
20. V1.1 channels in skeletal muscle. Proc. Natl. Acad. Sci. USA 2005, 102:5274-5279.
21. V1.2 channel by its proteolytically processed distal C-terminal domain. J.Physiol. 2006, 576:87-102.
22. 2+ channels. J.Cell. Physiol. 2008, 214:422-433.
23. 2+ channel α1A subunits translocate to nuclei and promote polyglutamine-mediated toxicity. Hum. Mol. Genet. 2006, 15:1587-1599.
24. Lai Y., Seagar M.J., Takahashi M., Catterall W.A. Cyclic AMP-dependent phosphorylation of two size forms of α1 subunits of L-type calcium channels in rat skeletal muscle cells. J.Biol. Chem. 1990, 265:20839-20848.
25. 2+-channels. Eur. J. Neurosci. 2002, 15:13-18.
26. v2.2 channels in hippocampal neurons. J.Neurosci. 2008, 28:11333-11346.
27. V1.2 channelopathies: from arrhythmias to autism, bipolar disorder, and immunodeficiency. Pflugers Arch. 2010, 460:353-359.
28. Malouf N.N., McMahon D.K., Hainsworth C.N., Kay B.K. A two-motif isoform of the major calcium channel subunit in skeletal muscle. Neuron 1992, 8:899-906.
29. Mezghrani A., Monteil A., Watschinger K., Sinnegger-Brauns M.J., Barrère C., Bourinet E., Nargeot J., Striessnig J., Lory P. A destructive interaction mechanism accounts for dominant-negative effects of misfolded mutants of voltage-gated calcium channels. J.Neurosci. 2008, 28:4501-4511.
30. Moyer J.R., Thompson L.T., Black J.P., Disterhoft J.F. Nimodipine increases excitability of rabbit CA1 pyramidal neurons in an age- and concentration-dependent manner. J.Neurophysiol. 1992, 68:2100-2109.
31. 2+ channel expression. Dev. Biol. 2001, 230:258-277.
32. Page K.M., Heblich F., Davies A., Butcher A.J., Leroy J., Bertaso F., Pratt W.S., Dolphin A.C. Dominant-negative calcium channel suppression by truncated constructs involves a kinase implicated in the unfolded protein response. J.Neurosci. 2004, 24:5400-5409.
33. V2 calcium channels: implications for episodic ataxia type 2. J.Biol. Chem. 2010, 285:835-844.
34. V2.1 channelopathies. Pflugers Arch. 2010, 460:375-393.
35. v2.2 induced by truncated constructs. J.Neurosci. 2001, 21:8495-8504.
36. 12.1 truncations requires the conserved interaction domain for β subunits. Mol. Cell. Neurosci. 2007, 34:168-177.
37. 2+ channel in saccular hair cells. Neuroscience 2006, 139:1417-1434.
38. Rechsteiner M., Rogers S.W. PEST sequences and regulation by proteolysis. Trends Biochem. Sci. 1996, 21:267-271.
39. Sakurai T., Hell J.W., Woppmann A., Miljanich G.P., Catterall W.A. Immunochemical identification and differential phosphorylation of alternatively spliced forms of the α1A subunit of brain calcium channels. J.Biol. Chem. 1995, 270:21234-21242.
40. Schiff M.L., Siderovski D.P., Jordan J.D., Brothers G., Snow B., De Vries L., Ortiz D.F., Diversé-Pierluissi M. Tyrosine-kinase-dependent recruitment of RGS12 to the N-type calcium channel. Nature 2000, 408:723-727.
41. 2+ channels. J.Neurosci. 1998, 18:641-647.
42. Smoller J.W., Craddock N., Kendler K., Lee P.H., Neale B.M., Nurnberger J.I., Ripke S., Santangelo S., Sullivan P.F. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Lancet 2013, 381:1371-1379. Cross-Disorder Group of the Psychiatric Genomics Consortium, Genetic Risk Outcome of Psychosis (GROUP) ConsortiumGenetic Risk Outcome of Psychosis (GROUP) Consortium.
43. 2+ channels. Pflugers Arch. 2010, 460:361-374.
44. 2+ channel. Cell 2008, 133:1228-1240.
45. Thibault O., Landfield P.W. Increase in single L-type calcium channels in hippocampal neurons during aging. Science 1996, 272:1017-1020.
46. Thibault O., Porter N.M., Chen K.C., Blalock E.M., Kaminker P.G., Clodfelter G.V., Brewer L.D., Landfield P.W. Calcium dysregulation in neuronal aging and Alzheimer's disease: history and new directions. Cell Calcium 1998, 24:417-433.
47. V2.2 channels by reducing their proteasomal degradation. J.Biol. Chem. 2011, 286:9598-9611.
48. v2.1 missense mutations associated with episodic ataxia type 2 and progressive ataxia. J.Biol. Chem. 2002, 277:6960-6966.
49. Westenbroek R.E., Sakurai T., Elliott E.M., Hell J.W., Starr T.V., Snutch T.P., Catterall W.A. Immunochemical identification and subcellular distribution of the α1A subunits of brain calcium channels. J.Neurosci. 1995, 15:6403-6418.
50. Wheeler D.G., Groth R.D., Ma H., Barrett C.F., Owen S.F., Safa P., Tsien R.W. Ca(V)1 and Ca(V)2 channels engage distinct modes of Ca(2+) signaling to control CREB-dependent gene expression. Cell 2012, 149:1112-1124.
51. Woppmann A., Ramachandran J., Miljanich G.P. Calcium channel subtypes in rat brain: biochemical characterization of the high-affinityreceptors for ω-conopeptides SNX-230 (synthetic MVIIC), SNX-183 (SVIB), and SNX-111 (MVIIA). Mol. Cell. Neurosci. 1994, 5:350-357.
52. Zamponi G.W., Currie K.P. Regulation of Ca(V)2 calcium channelsby G protein coupled receptors. Biochim. Biophys. Acta 2013, 1828:1629-1643.
53. Zamponi G.W., Lory P., Perez-Reyes E. Role of voltage-gated calcium channels in epilepsy. Pflugers Arch. 2010, 460:395-403.
54. Zhen X.G., Xie C., Yamada Y., Zhang Y., Doyle C., Yang J. A single amino acid mutation attenuates rundown of voltage-gated calcium channels. FEBS Lett. 2006, 580:5733-5738.