Biodegradable Fe-based alloys for use in osteosynthesis: Outcome of an in vivo study after 52 weeks

Acta Biomaterialia

Volumn 10, Issue 7, 2014, Pages 3346-3353

  Kraus, Tanja ^a   Moszner, Frank ^b   Fischerauer, Stefan ^a   Fiedler, Michael ^a   Martinelli, Elisabeth ^a   Eichler, Johannes ^a   Witte, Frank ^c   Willbold, Elmar ^d   Schinhammer, Michael ^b   Meischel, Martin ^e   Uggowitzer, Peter J ^b   Löffler, Jörg F ^b   Weinberg, Annelie ^a  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

^b ETH ZURICH   (Switzerland)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d HANNOVER MEDICAL SCHOOL   (Germany)

^e UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES   (Austria)

Author keywords

Biodegradation; Fracture fixation; Iron; Iron alloys; CT

Indexed keywords

BIODEGRADATION; COMPUTERIZED TOMOGRAPHY; IRON ALLOYS; MANGANESE ALLOYS; OXYGEN; PALLADIUM ALLOYS; SURFACE ANALYSIS;

EX-VIVO; FE-BASED ALLOYS; FE-BASED MATERIALS; IN-VIVO; OSTEOSYNTHESIS; PERFORMANCE; PURE FE; SPRAGUE-DAWLEY RATS; VIVO STUDIES; ΜCT;

DEGRADATION;

ALLOY; CALCIUM ION; IRON; MANGANESE DERIVATIVE; PALLADIUM COMPLEX; POTASSIUM; SODIUM; BIOMATERIAL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIODEGRADABILITY; BONE IMPLANT; CHEMICAL COMPOSITION; COMPUTER ASSISTED TOMOGRAPHY; DEGRADATION; ELECTRON MICROSCOPY; EX VIVO STUDY; FEMUR; IMPLANTATION; IN VIVO STUDY; INFLAMMATION; MALE; NONHUMAN; OSTEOSYNTHESIS; OXYGEN TRANSPORT; PET SCANNER; PRIORITY JOURNAL; RAT; SKELETON; SURFACE PROPERTY; SWELLING; TISSUE SECTION; WEIGHT BEARING; WEIGHT REDUCTION; WOUND HEALING; ANIMAL; BONE DEVELOPMENT; CHEMISTRY; SCANNING ELECTRON MICROSCOPY; SPRAGUE DAWLEY RAT;

RATTUS;

ALLOYS; ANIMALS; BIOCOMPATIBLE MATERIALS; IRON; MALE; MICROSCOPY, ELECTRON, SCANNING; OSTEOGENESIS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84901753585     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2014.04.007     Document Type: Article

References (30)

1. H. Hermawan, D. Dube, and D. Mantovani Developments in metallic biodegradable stents Acta Biomater 6 2010 1693 1697
2. M.P. Staiger, A.M. Pietak, J. Huadmai, and G. Dias Magnesium and its alloys as orthopedic biomaterials: a review Biomaterials 27 2006 1728 1734
3. B. O'Brien, and W. Carroll The evolution of cardiovascular stent materials and surfaces in response to clinical drivers: a review Acta Biomater 5 2009 945 958
4. A. Hänzi, A. Metlar, M. Schinhammer, H. Aguib, T. Lüth, and J.F. Löffler et al. Biodegradable wound-closing devices for gastrointestinal interventions: degradation performance of the magnesium tip Mater Sci Eng C 31 2011 1098 1103
5. A.H. Ng, N.S. Ng, G.H. Zhu, L.H. Lim, and S.S. Venkatraman A fully degradable tracheal stent: in vitro and in vivo characterization of material degradation J Biomed Mater Res B Appl Biomater 100 2012 693 699
6. K. Wang, S. Yuan, X. Zhang, Q. Liu, Q. Zhong, and R. Zhang et al. Biodegradable flow-diverting device for the treatment of intracranial aneurysm: short-term results of a rabbit experiment Neuroradiology 55 2013 621 628
7. R. Waksman, R. Pakala, R. Baffour, R. Seabron, D. Hellinga, and F.O. Tio Short-term effects of biocorrodible iron stents in porcine coronary arteries J Interv Cardiol 21 2008 15 20
8. M. Peuster, C. Fink, P. Wohlsein, M. Bruegmann, A. Gunther, and V. Kaese et al. Degradation of tungsten coils implanted into the subclavian artery of New Zealand white rabbits is not associated with local or systemic toxicity Biomaterials 24 2003 393 399
9. M. Peuster, C. Hesse, T. Schloo, C. Fink, P. Beerbaum, and C. von Schnakenburg Long-term biocompatibility of a corrodible peripheral iron stent in the porcine descending aorta Biomaterials 27 2006 4955 4962
10. M. Peuster, V. Kaese, G. Wuensch, P. Wuebbolt, M. Niemeyer, and R. Boekenkamp et al. Dissolution of tungsten coils leads to device failure after transcatheter embolisation of pathologic vessels Heart 85 2001 703 704
11. M. Schinhammer, A.C. Hanzi, J.F. Löffler, and P.J. Uggowitzer Design strategy for biodegradable Fe-based alloys for medical applications Acta Biomater 6 2010 1705 1713
12. F. Moszner, A. Sologubenkoa, M. Schinhammer, C. Lerchbacher, A. Hänzi, and H. Leitnerc et al. Precipitation hardening of biodegradable Fe-Mn-Pd alloys Acta Mater 59 2011 981 991
13. M. Schinhammer, C. Pecnik, F. Rechberger, A. Hänzi, J.F. Löffler, and P.J. Uggowitzer Recrystallization behavior, microstructure evolution and mechanical properties of biodegradable Fe-Mn-C(-Pd) TWIP alloys Acta Mater 60 2012 2746 2756
14. M. Schinhammer, I. Gerber, A.C. Hänzi, and P.J. Uggowitzer On the cytocompatibility of biodegradable Fe-based alloys Mater Sci Eng C 33 2013 782 789
15. M. Schinhammer, P. Steiger, F. Moszner, J.F. Löffler, and P.J. Uggowitzer Degradation performance of biodegradable Fe-Mn-C(-Pd) alloys Mater Sci Eng C Mater Biol Appl 33 2013 1882 1893
16. T. Kraus, S.F. Fischerauer, A.C. Hanzi, P.J. Uggowitzer, J.F. Löffler, and A.M. Weinberg Magnesium alloys for temporary implants in osteosynthesis: in vivo studies of their degradation and interaction with bone Acta Biomater 8 2012 1230 1238
17. E. Willbold, and F. Witte Histology and research at the hard tissue-implant interface using Technovit 9100 New embedding technique Acta Biomater 6 2010 4447 4455
18. E. Willbold, M. Reebmann, R. Jeffries, and F. Witte Electrochemical removal of metallic implants from Technovit 9100 New embedded hard and soft tissues prior to histological sectioning Histochem Cell Biol 2013
19. M. Mulisch, and U. Welsch Mikroskopische Technik M. Mulisch, U. Welsch, Romeis. Mikroskopische Technik 18th ed 2010 Spektrum Akademischer Verlag Heidelberg 400
20. A. Pearse Histochemistry: theoretical and applied 3rd ed. 1972 Churchill-Livingstone Edinburgh and London
21. O. Watzke, and W.A. Kalender A pragmatic approach to metal artifact reduction in CT: merging of metal artifact reduced images Eur Radiol 14 2004 849 856
22. H. Hermawan, A. Purnama, D. Dube, J. Couet, and D. Mantovani Fe-Mn alloys for metallic biodegradable stents: degradation and cell viability studies Acta Biomater 6 2010 1852 1860
23. M. Peuster, P. Wohlsein, M. Brugmann, M. Ehlerding, K. Seidler, and C. Fink et al. A novel approach to temporary stenting: degradable cardiovascular stents produced from corrodible metal-results 6-18 months after implantation into New Zealand white rabbits Heart 86 2001 563 569
24. K. Tostmann Korrosion: Ursachen und Vermeidung 2006 Wiley-VCH Weinheim 9783527302031 10.1002/352760331X
25. P. Sinha, and R. Feser Phosphate coating on steel surfaces by an electrochemical method Surf Coat Technol 161 2002 158 168
26. P. Persson, N. Nilsson, and S. Sjöberg Structure and bonding of orthophosphate ions at the iron oxide-aqueous interface J Colloid Interface Sci 177 1996 263 275
27. W. Revie, and H. Uhlig Corrosion and corrosion control 4th ed. 2008 John Wiley New York
28. H. Hermawan, D. Dubé, and D. Mantovani Degradable metallic biomaterials: design and development of Fe-Mn alloys for stents J Biomed Mater Res A 93A 2010 1 11
29. F. Moszner, S.S.A. Gerstl, P.J. Uggowitzer, and J.F. Löffler Atomic-scale characterization of prior austenite grain boundaries in Fe-Mn-based maraging steel using site-specific atom probe tomography Acta Mater 2014 < http://doi.org/10.1016/j.actamat.2014.04.009 >, [in press]
30. S. Zhu, N. Huang, L. Xu, Y. Zhang, H. Liu, and H. Sun et al. Biocompatibility of pure iron: in vitro assessment of degradation kinetics and cytotoxicity on endothelial cells Mater Sci Eng C 29 2009 1589 1592