Delivery of polysaccharides using polymer particles: Implications on size-dependent immunogenicity, opsonophagocytosis, and protective immunity

Molecular Pharmaceutics

Volumn 11, Issue 3, 2014, Pages 922-937

  Anish, Chakkumkal ^a,b   Khan, Naeem ^a   Upadhyay, Arun Kumar ^a,c   Sehgal, Devinder ^a   Panda, Amulya Kumar ^a  

^a NATIONAL INSTITUTE OF IMMUNOLOGY   (India)

^b MAX PLANCK INSTITUTE OF COLLOIDS AND INTERFACES   (Germany)

^c UNIVERSITY OF COLORADO   (United States)

Author keywords

antigen delivery systems; memory antibody; opsonophagocytic assay; pneumococcal capsular polysaccharides; pneumococcal surface antigen A (PsaA); pneumococcal surface protein A (PspA); polylactide nanoparticles

Indexed keywords

ANTIGEN; CARRIER PROTEIN; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; PNEUMOCOCCAL CAPSULAR POLYSACCHARIDE SEROTYPE 1; PNEUMOCOCCUS POLYSACCHARIDE; PNEUMOCOCCUS VACCINE; POLYLACTIDE; PSAA PROTEIN; PSPA PROTEIN; UNCLASSIFIED DRUG; BACTERIAL POLYSACCHARIDE; NANOPARTICLE; OPSONIN; POLYMER;

ADSORPTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY BLOOD LEVEL; ANTIBODY LABELING; ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; FEMALE; FLOW CYTOMETRY; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOGENICITY; IN VITRO STUDY; IN VIVO STUDY; LONG TERM MEMORY; MACROPHAGE; MOUSE; NONHUMAN; OPSONOPHAGOCYTOSIS; PARTICLE SIZE; PHAGOCYTOSIS; PNEUMOCOCCAL INFECTION; POLYMERIZATION; PRIORITY JOURNAL; SECONDARY IMMUNE RESPONSE; SINGLE DRUG DOSE; SURFACE PROPERTY; T LYMPHOCYTE ACTIVATION; ZETA POTENTIAL; ANIMAL; ANTIBODY PRODUCTION; ANTIGEN PRESENTING CELL; BAGG ALBINO MOUSE; CELL CULTURE; CHEMISTRY; CYTOLOGY; IMMUNOLOGY; METABOLISM; MICROBIOLOGY; PHYSIOLOGY; PNEUMOCOCCAL INFECTIONS;

ANIMALS; ANTIBODY FORMATION; ANTIGEN-PRESENTING CELLS; CELLS, CULTURED; FEMALE; IMMUNIZATION; MACROPHAGES; MICE; MICE, INBRED BALB C; NANOPARTICLES; OPSONIN PROTEINS; PHAGOCYTOSIS; PNEUMOCOCCAL INFECTIONS; PNEUMOCOCCAL VACCINES; POLYMERS; POLYSACCHARIDES, BACTERIAL;

EID: 84901744022     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp400589q     Document Type: Article

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