Bubble liposomes and ultrasound exposure improve localized morpholino oligomer delivery into the skeletal muscles of dystrophic mdx mice

Molecular Pharmaceutics

Volumn 11, Issue 3, 2014, Pages 1053-1061

  Negishi, Yoichi ^a   Ishii, Yuko ^a   Shiono, Hitomi ^a   Akiyama, Saki ^a   Sekine, Shoko ^a   Kojima, Takuo ^a   Mayama, Sayaka ^a   Kikuchi, Taiki ^a   Hamano, Nobuhito ^a   Endo Takahashi, Yoko ^a   Suzuki, Ryo ^b   Maruyama, Kazuo ^b   Aramaki, Yukihiko ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^b TEIKYO UNIVERSITY   (Japan)

Author keywords

Bubble liposomes; delivery of an antisense phosphorodiamidate morpholino oligomer (PMO); exon skipping therapy; muscular dystrophy; ultrasound

Indexed keywords

BUBBLE LIPOSOME; DYSTROPHIN; LIPOSOME; MACROGOL; MORPHOLINO OLIGONUCLEOTIDE; UNCLASSIFIED DRUG; ANTISENSE OLIGONUCLEOTIDE; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTISENSE THERAPY; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG POTENCY; DUCHENNE MUSCULAR DYSTROPHY; EXON; EXON SKIPPING; GENE EXPRESSION; GENE TARGETING; IN VITRO STUDY; IN VIVO GENE TRANSFER; IN VIVO STUDY; MALE; MOUSE; MOUSE MUTANT; MUSCULAR DYSTROPHY; NON INVASIVE PROCEDURE; NONHUMAN; NONSENSE MUTATION; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; SKELETAL MUSCLE; ULTRASOUND; X CHROMOSOME LINKED MUSCULAR DYSTROPHIC MOUSE; ANIMAL; ANTAGONISTS AND INHIBITORS; APOPTOSIS; C57BL MOUSE; CELL CULTURE; CELL PROLIFERATION; ENZYME IMMUNOASSAY; GENE THERAPY; GENE TRANSFER; GENETICS; METABOLISM; MUSCULAR DYSTROPHY, DUCHENNE; PATHOLOGY; PHYSIOLOGY; RADIATION RESPONSE; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL PROLIFERATION; CELLS, CULTURED; DYSTROPHIN; GENE TRANSFER TECHNIQUES; GENETIC THERAPY; IMMUNOENZYME TECHNIQUES; LIPOSOMES; MICE; MICE, INBRED C57BL; MICE, INBRED MDX; MORPHOLINOS; MUSCLE, SKELETAL; MUSCULAR DYSTROPHY, DUCHENNE; OLIGONUCLEOTIDES, ANTISENSE; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; ULTRASONICS;

EID: 84901742304     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp4004755     Document Type: Article

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