Association between warfarin combined with serotonin-modulating antidepressants and increased case fatality in primary intracerebral hemorrhage: A population-based study: Clinical article

Journal of Neurosurgery

Volumn 120, Issue 6, 2014, Pages 1358-1363

  Löppönen, Pekka ^a   Tetri, Sami ^a   Juvela, Seppo ^b   Huhtakangas, Juha ^a   Saloheimo, Pertti ^a   Bode, Michaela K ^a   Hillbom, Matti ^a  

^a OULU UNIVERSITY HOSPITAL   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Case fatality; Intracerebral hemorrhage; Serotonin modulating antidepressant; Vascular disorders; Warfarin

Indexed keywords

ACETYLSALICYLIC ACID; CITALOPRAM; ESCITALOPRAM; FLUOXETINE; MIRTAZAPINE; PAROXETINE; WARFARIN;

AGED; ANTICOAGULANT THERAPY; ARTICLE; BRAIN HEMORRHAGE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DRUG FATALITY; FEMALE; FINLAND; HUMAN; INDEPENDENT VARIABLE; KAPLAN MEIER METHOD; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; OUTCOME ASSESSMENT; PREDICTOR VARIABLE; PRESCRIPTION; PRIORITY JOURNAL; PSYCHOPHARMACOTHERAPY;

CASE FATALITY; GCS = GLASGOW COMA SCALE; ICH = INTRACEREBRAL HEMORRHAGE; INR = INTERNATIONAL NORMALIZED RATIO; INTRACEREBRAL HEMORRHAGE; PTCC = PROTHROMBIN COMPLEX CONCENTRATE; SEROTONIN-MODULATING ANTIDEPRESSANT; SNRI = SEROTONIN-NOREPINEPHRINE REUPTAKE INHIBITOR; SSRI = SELECTIVE SEROTONIN REUPTAKE INHIBITOR; VASCULAR DISORDERS; WA-PICH = WARFARIN-ASSOCIATED PRIMARY ICH; WARFARIN;

AGED; AGED, 80 AND OVER; ANTICOAGULANTS; ANTIDEPRESSIVE AGENTS; CEREBRAL HEMORRHAGE; DEPRESSION; DRUG THERAPY, COMBINATION; FEMALE; FINLAND; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; RETROSPECTIVE STUDIES; RISK FACTORS; SEROTONIN UPTAKE INHIBITORS; STROKE; SURVIVAL RATE; TREATMENT OUTCOME; WARFARIN;

EID: 84901707296     PISSN: 00223085     EISSN: 19330693     Source Type: Journal    
DOI: 10.3171/2013.12.JNS131898     Document Type: Article

References (23)

1. Bak S, Tsiropoulos I, Kjaersgaard JO, Andersen M, Mellerup E, Hallas J, et al: Selective serotonin reuptake inhibitors and the risk of stroke: a population-based case-control study. Stroke 33:1465-1473, 2002
2. Cucchiara B, Messe S, Sansing L, Kasner S, Lyden P: Hematoma growth in oral anticoagulant related intracerebral hemorrhage. Stroke 39:2993-2996, 2008
3. de Abajo FJ: Effects of selective serotonin reuptake inhibitors on platelet function: mechanisms, clinical outcomes and implications for use in elderly patients. Drugs Aging 28:345-367, 2011
4. de Abajo FJ, Jick H, Derby L, Jick S, Schmitz S: Intracranial haemorrhage and use of selective serotonin reuptake inhibitors. Br J Clin Pharmacol 50:43-47, 2000
5. Dentali F, Douketis JD, Lim W, Crowther M: Combined aspirin-oral anticoagulant therapy compared with oral anticoagulant therapy alone among patients at risk for cardiovascular disease: a meta-analysis of randomized trials. Arch Intern Med 167:117-124, 2007
6. Galan AM, Lopez-Vilchez I, Diaz-Ricart M, Navalon F, Gomez E, Gasto C, et al: Serotonergic mechanisms enhance platelet-mediated thrombogenicity. Thromb Haemost 102:511-519, 2009
7. Gasse C, Hollowell J, Meier CR, Haefeli WE: Drug interactions and risk of acute bleeding leading to hospitalisation or death in patients with chronic atrial fibrillation treated with warfarin. Thromb Haemost 94:537-543, 2005
8. Hackam DG, Mrkobrada M: Selective serotonin reuptake inhibitors and brain hemorrhage: a meta-analysis. Neurology 79:1862-1865, 2012
9. Huhtakangas J, Tetri S, Juvela S, Saloheimo P, Bode MK, Hillbom M: Effect of increased warfarin use on warfarin-related cerebral hemorrhage: a longitudinal population-based study. Stroke 42:2431-2435, 2011
10. Huhtakangas J, Tetri S, Juvela S, Saloheimo P, Bode MK, Karttunen V, et al: Improved survival of patients with warfarin-associated intracerebral haemorrhage: a retrospective longitudinal population-based study. Int J Stroke [epub ahead of print], 2012
11. Kharofa J, Sekar P, Haverbusch M, Moomaw C, Flaherty M, Kissela B, et al: Selective serotonin reuptake inhibitors and risk of hemorrhagic stroke. Stroke 38:3049-3051, 2007
12. Kuwashiro T, Yasaka M, Itabashi R, Nakagaki H, Miyashita F, Naritomi H, et al: Enlargement of acute intracerebral hematomas in patients on long-term warfarin treatment. Cerebrovasc Dis 29:446-453, 2010
13. Labos C, Dasgupta K, Nedjar H, Turecki G, Rahme E: Risk of bleeding associated with combined use of selective serotonin reuptake inhibitors and antiplatelet therapy following acute myocardial infarction. CMAJ 183:1835-1843, 2011
14. Morgenstern LB, Hemphill JC III, Anderson C, Becker K, Broderick JP, Connolly ES Jr, et al: Guidelines for the management of spontaneous intracerebral hemorrhage: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 41:2108-2129, 2010
15. Rosand J, Eckman MH, Knudsen KA, Singer DE, Greenberg SM: The effect of warfarin and intensity of anticoagulation on outcome of intracerebral hemorrhage. Arch Intern Med 164:880-884, 2004
16. Saloheimo P, Ahonen M, Juvela S, Pyhtinen J, Savolainen ER, Hillbom M: Regular aspirin-use preceding the onset of primary intracerebral hemorrhage is an independent predictor for death. Stroke 37:129-133, 2006
17. Schelleman H, Brensinger CM, Bilker WB, Hennessy S: Antidepressant- warfarin interaction and associated gastrointestinal bleeding risk in a case-control study. PLoS ONE 6:e21447, 2011
18. Smoller JW, Allison M, Cochrane BB, Curb JD, Perlis RH, Robinson JG, et al: Antidepressant use and risk of incident cardiovascular morbidity and mortality among postmenopausal women in the Women's Health Initiative study. Arch Intern Med 169:2128-2139, 2009
19. Teasdale G, Jennett B: Assessment of coma and impaired consciousness. A practical scale. Lancet 2:81-84, 1974
20. Tetri S, Hakala J, Juvela S, Saloheimo P, Pyhtinen J, Rusanen H, et al: Safety of low-dose subcutaneous enoxaparin for the prevention of venous thromboembolism after primary intracerebral haemorrhage. Thromb Res 123:206-212, 2008
21. Verdel BM, Souverein PC, Meenks SD, Heerdink ER, Leufkens HG, Egberts TC: Use of serotonergic drugs and the risk of bleeding. Clin Pharmacol Ther 89:89-96, 2011
22. World Health Organization, International Society of Hypertension Writing Group: 2003 World Health Organization (WHO)/International Society of Hypertension (ISH) statement on management of hypertension. J Hypertens 21:1983-1992, 2003
23. Zubkov AY, Mandrekar JN, Claassen DO, Manno EM, Wijdicks EF, Rabinstein AA: Predictors of outcome in warfarin-related intracerebral hemorrhage. Arch Neurol 65:1320-1325, 2008