Spontaneous voiding by mice reveals strain-specific lower urinary tract function to be a quantitative genetic trait

American Journal of Physiology - Renal Physiology

Volumn 306, Issue 11, 2014, Pages

  Yu, Weiqun ^a   Ackert Bicknell, Cheryl ^b   Larigakis, John D ^a   MacIver, Bryce ^a   Steers, William D ^c   Churchill, Gary A ^b   Hill, Warren G ^a   Zeidel, Mark L ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b JACKSON LABORATORY   (United States)

^c UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Animal model; Bladder; Heritability; Lower urinary tract symptoms; Micturition

Indexed keywords

PROTAMINE SULFATE; SUCROSE;

129S1/SVIMJ MOUSE; A J MOUSE; ANIMAL EXPERIMENT; ARTICLE; ASSAY; C57BL 6 MOUSE; CONTROLLED STUDY; CYSTOMETRY; DIURESIS; FEMALE; HERITABILITY; MICTURITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE TRAIT; SPONTANEOUS VOIDING ASSAY; URINARY TRACT FUNCTION; URINE VOLUME; URODYNAMICS;

ANIMAL MODEL; BLADDER; HERITABILITY; LOWER URINARY TRACT SYMPTOMS; MICTURITION;

ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; LOWER URINARY TRACT SYMPTOMS; MICE; MICE, INBRED STRAINS; PHENOTYPE; QUANTITATIVE TRAIT, HERITABLE; SPECIES SPECIFICITY; URINATION; URODYNAMICS;

EID: 84901706113     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00074.2014     Document Type: Article

References (35)

1. Andersson KE, Soler R, Fullhase C. Rodent models for urodynamic investigation. Neurourol Urodyn 30: 636-646, 2011.
2. Bronson FH, Maruniak JA. Male-induced puberty in female mice: evidence for a synergistic action of social cues. Biol Reprod 13: 94-98, 1975.
3. Cannon TW, Damaser MS. Effects of anesthesia on cystometry and leak point pressure of the female rat. Life Sci 69: 1193-1202, 2001.
4. Chang A, Butler S, Sliwoski J, Valentino R, Canning D, Zderic S. Social stress in mice induces voiding dysfunction and bladder wall remodeling. Am J Physiol Renal Physiol 297: F1101-F1108, 2009.
5. Churchill GA, Gatti DM, Munger SC, Svenson KL. The Diversity Outbred mouse population. Mamm Genome 23: 713-718, 2012.
6. Consortium CC. The genome architecture of the Collaborative Cross mouse genetic reference population. Genetics 190: 389-401, 2012.
7. Dagg AI, Bell WL, Windsor DE. Urine marking of cages and visual isolation as possible sources for error in behavioural studies of small mammals. Lab Anim 5: 163-167, 1971.
8. Daneshgari F, Huang X, Liu G, Bena J, Saffore L, Powell CT. Temporal differences in bladder dysfunction caused by diabetes, diuresis, and treated diabetes in mice. Am J Physiol Regul Integr Comp Physiol 290: R1728-R1735, 2006.
9. deCatanzaro D, Khan A, Berger RG, Lewis E. Exposure to developing females induces polyuria, polydipsia, and altered urinary levels of creatinine, 17beta-estradiol, and testosterone in adult male mice (Mus musculus). Horm Behav 55: 240-247, 2009.
10. Desjardins C, Maruniak JA, Bronson FH. Social rank in house mice: differentiation revealed by ultraviolet visualization of urinary marking patterns. Science 182: 939-941, 1973.
11. Gevaert T, Vriens J, Segal A, Everaerts W, Roskams T, Talavera K, Owsianik G, Liedtke W, Daelemans D, Dewachter I, Van Leuven F, Voets T, De Ridder D, Nilius B. Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding. J Clin Invest 117: 3453-3462, 2007.
12. Henderson ND, Turri MG, DeFries JC, Flint J. QTL analysis of multiple behavioral measures of anxiety in mice. Behav Genet 34: 267-293, 2004.
13. Hill WG, Meyers S, von Bodungen M, Apodaca G, Dedman JR, Kaetzel MA, Zeidel ML. Studies on localization and function of annexin A4a within urinary bladder epithelium using a mouse knockout model. Am J Physiol Renal Physiol 294: F919-F927, 2008.
14. Hodges SJ, Zhou G, Deng FM, Aboushwareb T, Turner C, Andersson KE, Santago P, Case D, Sun TT, Christ GJ. Voiding pattern analysis as a surrogate for cystometric evaluation in uroplakin II knockout mice. J Urol 179: 2046-2051, 2008.
15. Hurst JL. The functions of urine marking in a free-living population of house mice, Mus domesticus Rutty. Anita Behav 35: 1433-1442, 1987.
16. Jurgens HS, Schurmann A, Kluge R, Ortmann S, Klaus S, Joost HG, Tschop MH. Hyperphagia, lower body temperature, and reduced running wheel activity precede development of morbid obesity in New Zealand obese mice. Physiol Genomics 25: 234-241, 2006.
17. Kanasaki K, Yu W, von Bodungen M, Larigakis JD, Kanasaki M, Ayala de la Pena F, Kalluri R, Hill WG. Loss of 1-integrin from urothelium results in overactive bladder and incontinence in mice: a mechanosensory rather than structural phenotype. FASEB J 27: 1950-1961, 2013.
18. Lavelle J, Meyers S, Ramage R, Bastacky S, Doty D, Apodaca G, Zeidel ML. Bladder permeability barrier: recovery from selective injury of surface epithelial cells. Am J Physiol Renal Physiol 283: F242-F253, 2002.
19. Lavelle J, Meyers S, Ramage R, Doty D, Bastacky S, Apoddaca G, Zeidel M. Protamine sulfate-induced cystitis: a model of selective cytodestruction of the urothelium. Urology 57: 113, 2001.
20. Logan RW, Robledo RF, Recla JM, Philip VM, Bubier JA, Jay JJ, Harwood C, Wilcox T, Gatti DM, Bult CJ, Churchill GA, Chesler EJ. High-precision genetic mapping of behavioral traits in the diversity outbred mouse population. Genes Brain Behav 12: 424-437, 2013.
21. Maruniak JA, Owen K, Bronson FH, Desjardins C. Urinary marking in female house mice: effects of ovarian steroids, sex experience, and type of stimulus. Behav Biol 13: 211-217, 1975.
22. Maruniak JA, Owen K, Bronson FH, Desjardins C. Urinary marking in male house mice: responses to novel environmental and social stimuli. Physiol Behav 12: 1035-1039, 1974.
23. Matsuura S, Downie JW. Effect of anesthetics on reflex micturition in the chronic cannula-implanted rat. Neurourol Urodyn 19: 87-99, 2000.
24. Milner LC, Crabbe JC. Three murine anxiety models: results from multiple inbred strain comparisons. Genes Brain Behav 7: 496-505, 2008.
25. Reynolds E. Urination as a social response in mice. Nature 234: 481-483, 1971.
26. Smith PP, Hurtado E, Smith CP, Boone TB, Somogyi GT. Comparison of cystometric methods in female rats. Neurourol Urodyn 27: 324-329, 2008.
27. Smith PP, Kuchel GA. Continuous uroflow cystometry in the urethaneanesthetized mouse. Neurourol Urodyn 29: 1344-1349, 2010.
28. Sugino Y, Kanematsu A, Hayashi Y, Haga H, Yoshimura N, Yoshimura K, Ogawa O. Voided stain on paper method for analysis of mouse urination. Neurourol Urodyn 27: 548-552, 2008.
29. Svenson KL, Gatti DM, Valdar W, Welsh CE, Cheng R, Chesler EJ, Palmer AA, McMillan L, Churchill GA. High-resolution genetic mapping using the Mouse Diversity outbred population. Genetics 190: 437-447, 2012.
30. Thiessen D, Rice M. Mammalian scent gland marking and social behavior. Psychol Bull 83: 505-539, 1976.
31. Wang CC, Nagatomi J, Toosi KK, Yoshimura N, Hsieh JH, Chancellor MB, Sacks MS. Diabetes-induced alternations in biomechanical properties of urinary bladder wall in rats. Urology 73: 911-915, 2009.
32. Wood SK, Baez MA, Bhatnagar S, Valentino RJ. Social stress-induced bladder dysfunction: potential role of corticotropin-releasing factor. Am J Physiol Regul Integr Comp Physiol 296: R1671-R1678, 2009.
33. Xiao N, Wang Z, Huang Y, Daneshgari F, Liu G. Roles of polyuria and hyperglycemia in bladder dysfunction in diabetes. J Urol 189: 1130-1136, 2013.
34. Yaksh TL, Durant PA, Brent CR. Micturition in rats: a chronic model for study of bladder function and effect of anesthetics. Am J Physiol Regul Integr Comp Physiol 251: R1177-R1185, 1986.
35. Yuan R, Tsaih SW, Petkova SB, Marin de Evsikova C, Xing S, Marion MA, Bogue MA, Mills KD, Peters LL, Bult CJ, Rosen CJ, Sundberg JP, Harrison DE, Churchill GA, Paigen B. Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels. Aging Cell 8: 277-287, 2009.