Social stress in mice induces voiding dysfunction and bladder wall remodeling

American Journal of Physiology - Renal Physiology

Volumn 297, Issue 4, 2009, Pages

  Chang, Andy ^a   Butler, Stephan ^a   Sliwoski, Joanna ^a   Valentino, Rita ^a   Canning, Douglas ^a   Zderic, Stephen ^a  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

Calcineurin; Dysfunctional voiding; Mind body interaction; NFAT; Smooth muscle

Indexed keywords

BROXURIDINE; ISOPROTEIN; MESSENGER RNA; MYOCYTE ENHANCER FACTOR 2; MYOSIN HEAVY CHAIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NFAT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLADDER WALL; CONTROLLED STUDY; CYSTOMETRY; HYPERTROPHY; LAMINA PROPRIA; MALE; MICTURITION; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSYCHOLOGICAL ASPECT; SOCIAL STRESS; URINARY DYSFUNCTION; URINE RETENTION; URINE VOLUME; UROTHELIUM;

EID: 70349634395     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.90749.2008     Document Type: Article

References (34)

1. Austin JC, Chacko SK, DiSanto M, Canning DA, Zderic SA. A male murine model of partial bladder outlet obstruction reveals changes in detrusor morphology, contractility and Myosin isoform expression. J Urol 172: 1524-1528, 2004. (Pubitemid 39249762)
2. Babu GJ, Pyne GJ, Zhou Y, Okwuchukuasanya C, Brayden JE, Osol G, Paul RJ, Low RB, Periasamy M. Isoform switching from SM-B to SM-A myosin results in decreased contractility and altered expression of thin filament regulatory proteins. Am J Physiol Cell Physiol 287: C723-C729, 2004. (Pubitemid 39095859)
3. Benoit RM, Wise BV, Naslund MJ, Mathews R, Docimo SG. The effect of dysfunctional voiding on the costs of treating vesicoureteral reflux: a computer model. J Urol 168: 2173-2176, 2002.
4. Bhattacharya A, Dang H, Zhu QM, Schnegelsberg B, Rozengurt N, Cain G, Prantil R, Vorp DA, Guy N, Julius D, Ford AP, Lester HA, Cockayne DA. Uropathic observations in mice expressing a constitutively active point mutation in the 5-HT3A receptor subunit. J Neurosci 24: 5537-5548, 2004. (Pubitemid 38812636)
5. Birder LA, Nakamura Y, Kiss S, Nealen ML, Barrick S, Kanai AJ, Wang E, Ruiz G, De Groat WC, Apodaca G, Watkins S, Caterina MJ. Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1. Nat Neurosci 5: 856-860, 2002. (Pubitemid 34976650)
6. Burnett AL, Calvin DC, Chamness SL, Liu JX, Nelson RJ, Klein SL, Dawson VL, Dawson TM, Snyder SH. Urinary bladder-urethral sphincter dysfunction in mice with targeted disruption of neuronal nitric oxide synthase models idiopathic voiding disorders in humans. Nat Med 3: 571-574, 1997.
7. Clement M, Delaney DP, Austin JC, Sliwoski J, Hii GC, Canning DA, DiSanto ME, Chacko SK, Zderic SA. Activation of the calcineurin pathway is associated with detrusor decompensation: a potential therapeutic target. J Urol 176: 1225-1229, 2006. (Pubitemid 44142584)
8. Crabtree GR, Olson EN. NFAT signaling: choreographing the social lives of cells. Cell 109, Suppl: S67-S79, 2002.
9. Desjardins C, Maruniak JA, Bronson FH. Social rank in house mice: differentiation revealed by ultraviolet visualization of urinary marking patterns. Science 182: 939-941, 1973.
10. Ellsworth PI, Merguerian PA, Copening ME. Sexual abuse: another causative factor in dysfunctional voiding. J Urol 153: 773-776, 1995.
11. Feldman AS, Bauer SB. Diagnosis and management of dysfunctional voiding. Curr Opin Pediatr 18: 139-147, 2006.
12. Fitzgerald MP, Thom DH, Wassel-Fyr C, Subak L, Brubaker L, Van Den Eeden SK, Brown JS. Childhood urinary symptoms predict adult overactive bladder symptoms. J Urol 175: 989-993, 2006. (Pubitemid 43200052)
13. Hinman F, Baumann FW. Vesical and ureteral damage from voiding dyfunction in boys without neurologic or obstuctive disease. J Urol 109: 727-732, 1973.
14. Hinman F Jr, Baumann FW. Complications of vesicoureteral operations from incoordination of micturition. J Urol 116: 638-643, 1976.
15. Huang PL, Dawson TM, Bredt DS, Snyder SH, Fishman MC. Targeted disruption of the neuronal nitric oxide synthase gene. Cell 75: 1273-1286, 1993. (Pubitemid 24021903)
16. Hurst JL, Payne CE, Nevison CM, Marie AD, Humphries RE, Robertson DH, Cavaggioni A, Beynon RJ. Individual recognition in mice mediated by major urinary proteins. Nature 414: 631-634, 2001. (Pubitemid 33151257)
17. Jusuf AA, Kojima S, Matsuo M, Tokuhisa T, Hatano M. Vesicourethral sphincter dysfunction in ncx deficient mice with an increased neuronal cell number in vesical ganglia. J Urol 165: 993-998, 2001. (Pubitemid 32156337)
18. Katoh Y, Molkentin JD, Dave V, Olson EN, Periasamy M. MEF2B is a component of a smooth muscle-specific complex that binds an A/T-rich element important for smooth muscle myosin heavy chain gene expression. J Biol Chem 273: 1511-1518, 1998. (Pubitemid 28133674)
19. Kiddoo DA, Valentino RJ, Zderic S, Ganesh A, Leiser SC, Hale L, Grigoriadis DE. Impact of state of arousal and stress neuropeptides on urodynamic function in freely moving rats. Am J Physiol Regul Integr Comp Physiol 290: R1697-R1706, 2006. (Pubitemid 43830837)
20. Klausner AP, Steers WD. Corticotropin releasing factor: a mediator of emotional influences on bladder function. J Urol 172: 2570-2573, 2004.
21. Lassmann J, Sliwoski J, Chang A, Canning DA, Zderic SA. Deletion of one SERCA2 allele confers protection against bladder wall hypertrophy in a murine model of partial bladder outlet obstruction. Am J Physiol Regul Integr Comp Physiol 294: R58-R65, 2008.
22. Lumley LA, Sipos ML, Charles RC, Charles RF, Meyerhoff JL. Social stress effects on territorial marking and ultrasonic vocalizations in mice. Physiol Behav 67: 769-775, 1999.
23. Molkentin JD, Lu JR, Antos CL, Markham B, Richardson J, Robbins J, Grant SR, Olson EN. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell 93: 215-228, 1998. (Pubitemid 28180855)
24. Nguyen MT, Pavlock CL, Zderic SA, Carr MC, Canning DA. Overnight catheter drainage in children with poorly compliant bladders improves postobstructive diuresis and urinary incontinence. J Urol 174: 1633-1636, 2005.
25. Rickenbacher E, Baez MA, Hale L, Leiser SC, Zderic SA, Valentino RJ. Impact of overactive bladder on the brain: central sequelae of a visceral pathology. Proc Natl Acad Sci USA 105: 10589-10594, 2008.
26. Sambrook J, Russel DW. Gel retardation assays for DNA binding proteins. In: Molecular Cloning: A Laboratory Manual. Cold Spring, NY: Cold Spring Harbor, 2001, p. 17.13-17.17.
27. Stein R, Gong C, Hutcheson J, Krasnopolsky L, Canning DA, Carr M, Zderic SA. The fate of urinary bladder smooth muscle after outlet obstruction-a role for the sarcoplasmic reticulum. Adv Exp Med Biol 539: 773-790, 2003. (Pubitemid 38962093)
28. Su X, Stein R, Stanton MC, Zderic S, Moreland RS. Effect of partial outlet obstruction on rabbit urinary bladder smooth muscle function. Am J Physiol Renal Physiol 284: F644-F652, 2003. (Pubitemid 36336970)
29. Sutherland RS, Kogan BA, Piechota HJ, Bredt DS. Vesicourethral function in mice with genetic disruption of neuronal nitric oxide synthase. J Urol 157: 1109-1116, 1997. (Pubitemid 27066327)
30. Valentino RJ, Page ME, Luppi PH, Zhu Y, Van Bockstaele E, Aston-Jones G. Evidence for widespread afferents to Barrington's nucleus, a brainstem region rich in corticotropin-releasing hormone neurons. Neuroscience 62: 125-143, 1994.
31. Valentino RJ, Pavcovich LA, Hirata H. Evidence for corticotropin- releasing hormone projections from Barrington's nucleus to the periaqueductal gray and dorsal motor nucleus of the vagus in the rat. J Comp Neurol 363: 402-422, 1995. (Pubitemid 26012245)
32. Wilkins BJ, Dai YS, Bueno OF, Parsons SA, Xu J, Plank DM, Jones F, Kimball TR, Molkentin JD. Calcineurin/NFAT coupling participates in pathological, but not physiological, cardiac hypertrophy. Circ Res 94: 110-118, 2004. (Pubitemid 38064105)
33. Wood SK, Baez MA, Bhatnagar S, Valentino RJ. Social stress-induced bladder dysfunction: potential role of corticotropin-releasing factor. Am J Physiol Regul Integr Comp Physiol In press.
34. Zhang EY, Stein R, Chang S, Zheng Y, Zderic SA, Wein AJ, Chacko S. Smooth muscle hypertrophy following partial bladder outlet obstruction is associated with overexpression of nonmuscle caldesmon. Am J Pathol 164: 601-612, 2004. (Pubitemid 38364675)