Acute impact of erythromycin on substrate utilization by activated sludge: Effect of sludge age

Journal of Chemical Technology and Biotechnology

Volumn 89, Issue 7, 2014, Pages 1091-1102

  Pala Ozkok, Ilke ^a   Ubay Cokgor, Emine ^a   Cakar, Zeynep Petek ^a   Orhon, Derin ^a,b  

^a ISTANBUL TECHNICAL UNIVERSITY   (Turkey)

^b The Science Academy   (Turkey)

Author keywords

Activated sludge; Degradation; Kinetics; Modelling; Pharmaceuticals

Indexed keywords

BATCH REACTORS; CHEMICAL OXYGEN DEMAND; DEGRADATION; DRUG PRODUCTS; ENZYME KINETICS; MAINTENANCE; MODELS; SUBSTRATES;

ACTIVATED SLUDGE; CONTROL REACTORS; ENDOGENOUS RESPIRATION; MICROBIAL CULTURE; OXYGEN UPTAKE RATES; PARALLEL REACTORS; SUBSTRATE UTILIZATION; UNCOMPETITIVE INHIBITIONS;

ANTIBIOTICS;

ERYTHROMYCIN; OXYGEN;

ACTIVATED SLUDGE; ARTICLE; BIODEGRADATION; BIOTRANSFORMATION; CHEMICAL OXYGEN DEMAND; CONTROLLED STUDY; ENERGY; GROWTH RATE; HYDROLYSIS; MICROBIAL GROWTH; MICROBIAL RESPIRATION; NONHUMAN; OXYGEN CONSUMPTION; SLUDGE; SUBSTRATE INDUCED RESPIRATION; SUBSTRATE UTILIZATION;

EID: 84901693536     PISSN: 02682575     EISSN: 10974660     Source Type: Journal    
DOI: 10.1002/jctb.4208     Document Type: Article

References (50)

1. Tenson T, Lovmar M and Ehrenberg M, The mechanism of action of macrolides, lincosamides and streptogramin B reveals the nascent peptide exit path in the ribosome. J Mol Biol 330:1005-1014 (2003).
2. Alighardashi A, Pandolfi D, Potier O and Pons MN, Acute sensitivity of activated sludge bacteria to erythromycin. J Hazard Mater 172:685-692 (2009).
3. Giger W, Alder AC, Golet EM, Kohler HPE, McArdell CS, Molnar E, Siegrist H and Suter MJF, Occurrence and fate of antibiotics as trace contaminants in wastewaters, sewage sludges, and surface waters. Chimia 57:485-491 (2003).
4. Radjenovic J, Petrovic M and Barcelo D, Analysis of pharmaceuticals in wastewater and removal using a membrane bioreactor. Anal Bioanal Chem 387:1365-1377 (2007).
5. Louvet JN, Giammarino C, Potier O and Pons MN, Adverse effects of erythromycin on the structure and chemistry of activated sludge. Environ Pollut 158:688-693 (2010).
6. Kümmerer K, Alexy R, Hüttig J and Schöll A, Standardized tests fail to assess the effects of antibiotics on environmental bacteria. Water Res 38:2111-2116 (2004).
7. Insel G, Karahan O, Ozdemir S, Pala I, Katipoglu T, Ubay-Cokgor E and Orhon D, Unified basis for the respirometric evaluation of inhibition for activated sludge. J Environ Sci Health A 41:1763-1780 (2006).
8. Ubay-Cokgor E, Insel G, Aydin E and Orhon D, Respirometric evaluation of a mixture of organic chemicals with different biodegradation kinetics. J Hazard Mater 161:35-41 (2009).
9. Vanrolleghem PA, Principles of respirometry in activated sludge wastewater treatment, in Proceedings of the International Workshop on Recent Development in Respirometry for Wastewater Treatment Plant Monitoring and Control, Taipei, Taiwan, October 22-23, 2/1-20) (2002).
10. Ciggin AS, Insel G, Majone M and Orhon D, Respirometric evaluation and modelling of acetate utilization in sequencing batch reactor under pulse and continuous feeding. Bioresource Technol 107:61-69 (2012).
11. Orhon D, Cokgor EU, Insel G, Karahan O and Katipoglu T, Validity of monod kinetics at different sludge ages - peptone biodegradation under aerobic conditions. Bioresource Technol 100:5678-5686 (2009).
12. Ubay Cokgor E, Arslan Alaton I, Karahan O, Dogruel S and Orhon D, Biological treatability of raw and ozonated penicillin formulation effluent. J Hazard Mater B116:159-166 (2004).
13. Pala-Ozkok I, Rehman A, Yagci N, Ubay-Cokgor E, Jonas D and Orhon D, Characteristics of mixed microbial culture at different sludge ages: effect on variable kinetics for substrate utilization. Bioresource Technol 126:274-282 (2012).
14. ISO 8192, Water Quality-Test for Inhibition of Oxygen Consumption by Activated Sludge. International Standards Organization, Switzerland (2007).
15. Pala-Ozkok I, Inhibitory impact of selected antibiotics on biodegradation characteristic and microbial population under aerobic conditions. PhD Thesis, Istanbul Technical University, Turkey (2012).
16. Kummerer K, Drugs in the environment: emission of drugs, diagnostic aids and disinfectants into wastewater by hospitals in relation to other sources, review. Chemosphere 45:957-969 (2001).
17. Larsson DG, de Pedro C and Paxeus N, Effluent from drug manufactures contains extremely high levels of pharmaceuticals. J Hazard Mater 148:751-755 (2007).
18. Chelliapan S, Wilby T and Sallis PJ, Performance of an up-flow anaerobic stage reactor (UASR) in the treatment of pharmaceutical wastewater containing macrolide antibiotics. Water Res 40:507-516 (2006).
19. Ozkok IP, Yazan TK, Cokgor EU, Insel G, Talinli I and Orhon D, Respirometric assessment of substrate binding by antibiotics in peptone biodegradation. J Environ Sci Health A 46:1588-1597 (2011).
20. Reichert P, Ruchti J and Simon W, AQUASIM 2.0, Swiss Federal Institute for Environmental Science and Technology (EAWAG), CH-8600 Duebendorf, Switzerland (1998).
21. ISO 6060, Water quality-determination of the chemical oxygen demand. International Standards Organization, Switzerland (1986).
22. Standard Methods for the Examination of Water and Wastewater, 21st edn. American Public Health Association/American Water Works Association/Water Environment Federation, Washington DC, USA (2005).
23. Beun JJ, Paletta F, van Loosdrecht MCM and Heijnen JJ, Stoichiometry and kinetics of poly-beta-hydroxybutyrate metabolism in aerobic, slowgrowing, activated sludge cultures. Biotechnol Bioeng 67:379-389 (2000).
24. Ubay Çokgor E, Insel G, Katipoglu T and Orhon D, Biodegradation kinetics of peptone and 2, 6-dihydrobenzoic acid by acclimated dual microbial culture. Bioresource Technol 102:567-575 (2011).
25. Katipoglu-Yazan T, Ubay-Cokgor E, Insel G and Orhon D, Is ammonification the rate limiting step for nitrification kinetics? Bioresource Technol 114:117-125 (2012).
26. Sutcliffe J, Grebe T, Tait-Kamradt A and Wondrack L, Detection of erythromycin-resistant determinants by PCR. Antimicrobiol Agents Ch 40:2562-2566 (1996).
27. Hocaoglu SM, Insel G, Ubay Cokgor E, Baban A and Orhon D, COD fractionation and biodegradation kinetics of segregated domestic wastewater: black and grey water fractions. J Chem Technol Biotechnol 85:1241-1249 (2010).
28. Daigger GT and Grady CPL, The dynamics of microbial-growth on soluble substrates-a unifying theory. Water Res 16:365-382 (1982).
29. Orhon D, Karahan O and Sozen S, The effect of residual microbial products on the experimental assessment of the particulate COD in wastewaters. Water Res 33:3191-3203 (1999).
30. van Loosdrecht MCM, Pot MA and Heijnen JJ, Importance of bacterial storage polymers in bioprocesses. Water Sci Technol 35:41-47 (1997).
31. Filipe CDM, Daigger GT and Grady CPL, Effects of pH on the rates of aerobic metabolism of phosphate-accumulating and glycogen-accumulating organisms. Water Environ Res 73:213-222 (2001).
32. Ucisik-Akkkaya E, Ercan O, Yesiladali SK, Ozturk T, Ubay-Cokgor E, Orhon D, Tamerler C and Cakar ZP, Enhanced polyhydroxyalkanoate production by Paracoccus pantotrophus from glucose and mixed substrate. Fresenius Environ Bull 18:2013-2022 (2009).
33. Zengin GE, Artan N, Orhon D, Satoh H and Mino T, Effect of aspartate and glutamate on the fate of enhanced biological phosphorus removal process and microbial community structure. Bioresource Technol 102:894-903 (2011).
34. Dircks K, Beun JJ, van Loosdrecht M, Heijnen JJ and Henze M, Glycogen metabolism in aerobic mixed cultures. Biotechnol Bioeng 73:85-94 (2001).
35. Durner R, Witholt B and Egli T, Accumulation of poly[(R)-3-hydroxyalkanoates] in Pseudomonas oleovorans during growth with octanoate in continuous culture at different dilution rates. Appl Environ Microbiol 66:3408-3414 (2000).
36. Orhon D and Ubay Cokgor E, COD fractionation in wastewater characterization: the state of the art. J Chem Technol Biotechnol 68:283-293 (1997).
37. Krishna C and van Loosdrecht MCM, Substrate flux into storage and growth in relation to activated sludge modeling. Water Res 33:3149-3161 (1999).
38. Plosz BGY, Leknes H and Thomas KV, Impacts of competitive inhibition, parent compound formation and partitioning behavior on the removal of antibiotics in municipal wastewater treatment. Environ Sci Technol 44:734-742 (2010).
39. Insel G, Orhon D and Vanrolleghem PA, Identification and modelling of aerobic hydrolysis-application of optimal experimental design. J Chem Technol Biotechnol 78:437-445 (2003).
40. Ciggin AS, Rossetti S, Majone M and Orhon D, Extent of intracellular storage in single and dual substrate systems under pulse feeding. Env Sci Pollut Res 20:1225-1238 (2013).
41. Brun R, Reichert P and Künsch RK, Practical identifiability analysis of large environmental simulation models. Water Res Res 37:1015-1030 (2001).
42. Orhon D, Cokgor EU and Sozen S, Dual hydrolysis model of the slowly biodegradable substrate in activated sludge systems. Biotechnol Tech 12:737-741 (1998).
43. Cetecioglu Z, Ince B, Orhon D and Ince O, Acute inhibitory impact of antimicrobials on acetoclastic methanogenic activity. Bioresource Technol 114:109-116 (2012).
44. Szczepanowski R, Krahn I, Linke B, Goesmann A, Pühler A and Schlüter A, Antibiotic multiresistance plasmid pRSB101 isolated from a wastewater treatment plant is related to plasmids residing in phytopathogenic bacteria and carries eight different resistance determinants including a multidrug transport system. Microbiology 150:3613-3630 (2004).
45. Zhang X-X, Zhang T and Fang HHP, Antibiotic resistance genes in water environment. Appl Microbiol Biotechnol 82:397-414 (2009).
46. van Bodegom P, Microbial maintenance a critical review on its quantification. Microbiol Ecol 53:513-523 (2007).
47. Tännler S, Decasper S and Sauer U, Maintenance metabolism and carbon fluxes in Bacillus species. Microbiol Cell Fact 7:19 (2008).
48. Stephanopoulos G, Nielsen J and Aristidou A, Metabolic Engineering. Principles and Methodologies, Academic Press, San Diego, California (1998).
49. Minkevich IG, Andreyev SV and Eroshin VK, The effect of two inhibiting substrates on growth kinetics and cell maintenance of the yeast Candida valida. Process Biochem 36:209-217 (2000).
50. Pala-Ozkok I, Kor-Bicakci G, Ural A, Katipoglu-Yazan T, Yagci N, Ubay-Cokgor E and Orhon D, Modeling acute impact of sulfamethoxazole on the utilization of simple and complex substrates by fast growing microbial culture. J Chem Technol Biotechnol DOI 10.1002/jctb.4165.