Genetic variants of Adam17 differentially regulate TGFβ signaling to modify vascular pathology in mice and humans

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 21, 2014, Pages 7723-7728

  Kawasaki, Kyoko ^a   Freimuth, Julia ^a   Meyer, Dominique S ^a   Lee, Marie M ^a   Tochimoto Okamoto, Akiko ^a   Benzinou, Michael ^a   Clermont, Frederic F ^a   Wu, Gloria ^a   Roy, Ritu ^b   Letteboer, Tom G W ^a,c   Ploos Van Amstel, Johannes Kristian ^c   Giraud, Sophie ^d   Dupuis Girod, Sophie ^d   Lesca, Gaeten ^d   Westermann, Cornelius J J ^e   Coffey Jr , Robert J ^f   Akhurst, Rosemary J ^a,b,g  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^d UNIVERSITÉ DE LYON   (France)

^e ST ANTONIUS HOSPITAL   (Netherlands)

^f VANDERBILT INGRAM CANCER CENTER   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN RECEPTOR LIKE KINASE 1; AMINO ACID; BONE MORPHOGENETIC PROTEIN RECEPTOR; ENDOGLIN; PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; TGFBM 3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; UNCLASSIFIED DRUG;

ALLELE; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN ARTERIOVENOUS MALFORMATION; CHROMOSOME 12; CLINICAL FEATURE; DISEASE SEVERITY; DOWN REGULATION; EMBRYO; EMBRYO CELL; ENDOTHELIAL PROGENITOR CELL; GENE INTERACTION; GENE MUTATION; GENETIC ASSOCIATION; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; HAPLOTYPE; HUMAN; INCIDENCE; LETHALITY; MOUSE; NONHUMAN; PENETRANCE; PHENOTYPE; PRIORITY JOURNAL; RENDU OSLER WEBER DISEASE; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; VASCULAR DISEASE;

ADAM PROTEINS; ANIMALS; BLOOD VESSELS; GENE EXPRESSION REGULATION; GENETIC VARIATION; HUMANS; IMMUNOHISTOCHEMISTRY; LUCIFERASES; MICE; MICE, INBRED C57BL; NIH 3T3 CELLS; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84901660537     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1318761111     Document Type: Article

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