Cyanidin-3-O-β-glucoside inhibits lipopolysaccharideinduced infl ammatory response in mouse mastitis model

Journal of Lipid Research

Volumn 55, Issue 6, 2014, Pages 1111-1119

  Fu, Yunhe ^a   Wei, Zhengkai ^a   Zhou, Ershun ^a   Zhang, Naisheng ^a   Yang, Zhengtao ^a  

^a JILIN UNIVERSITY   (China)

Author keywords

ATP binding cassette transporter G1; Interferon regulatory factor 3; Lipid raft; Liver X receptor; Nuclear factor B; Toll like receptor 4

Indexed keywords

ABC TRANSPORTER G1; ANTHOCYANIN; ANTIINFLAMMATORY AGENT; CHOLESTEROL; CYANIDIN 3 O BETA GLUCOSIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR 3; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; LIVER X RECEPTOR ALPHA; MYELOPEROXIDASE; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CYANIDIN 3-O-GLUCOSIDE; CYTOKINE; GLUCOSIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BREAST EPITHELIUM; CELL VIABILITY; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG STRUCTURE; ENZYME ACTIVITY; FEMALE; HISTOPATHOLOGY; INFLAMMATION; LIPID RAFT; MASTITIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; UPREGULATION; ANIMAL; CHEMICALLY INDUCED; DISEASE MODEL; HUMAN; METABOLISM; PATHOLOGY; UDDER;

ANIMALS; ANTHOCYANINS; CYTOKINES; DISEASE MODELS, ANIMAL; FEMALE; GLUCOSIDES; HUMANS; LIPOPOLYSACCHARIDES; MAMMARY GLANDS, ANIMAL; MASTITIS; MICE;

EID: 84901660360     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M047340     Document Type: Article

References (32)

1. Tankeyoon, M., N. Dusitsin, S. Chalapati, S. Koetsawang, S. Saibiang, M. Sas, J. J. Gellen, O. Ayeni, R. Gray, A. Pinol, et al. 1984. Effects of hormonal contraceptives on milk volume and infant growth. WHO Special Programme of Research, Development and Research Training in Human Reproduction Task force on oral contraceptives. Contraception. 30: 505-522.
2. Fox, L. K. 2009. Prevalence, incidence and risk factors of heifer mastitis. Vet. Microbiol. 134: 82-88.
3. Schmitz, S., M. W. Pfaffl, H. H. D. Meyer, and R. M. Bruckmaier. 2004. Short-term changes of mRNA expression of various infl ammatory factors and milk proteins in mammary tissue during LPSinduced mastitis. Domest. Anim. Endocrinol. 26: 111-126.
4. Hoshino, K., O. Takeuchi, T. Kawai, H. Sanjo, T. Ogawa, Y. Takeda, K. Takeda, and S. Akira. 1999. Cutting edge: Toll-like receptor 4 (TLR4)-defi cient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J. Immunol. 162: 3749-3752.
5. Fitzgerald, K . A., D. C. Rowe, B. J. Barnes, D. R. Caffrey, A. Visintin, E. Latz, B. Monks, P. M. Pitha, and D. T. Golenbock. 2003. LPSTLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF. J. Exp. Med . 198: 1043-1055.
6. Ulven, S. M., K. T. Dalen, J. A. Gustafsson, and H. I. Nebb. 2004. Tissue-specifi c autoregulation of the LXRalpha gene facilitates induction of apoE in mouse adipose tissue. J. Lipid Res. 45: 2052-2062.
7. Joseph, S. B., A. Castrillo, B. A. Laffi tte, D. J. Mangelsdorf, and P. Tontonoz. 2003. Reciprocal regulation of infl ammation and lipid metabolism by liver X receptors. Nat. Med. 9: 213-219.
8. Zelcer, N., and P. Tontonoz. 2006. Liver X receptors as integrators of metabolic and infl ammatory signaling. J. Clin. Invest. 116: 607-614.
9. Stefková, J., R. Poledne, and J. A. Hubácek. 2004. ATP-binding cassette (ABC) transporters in human metabolism and diseases. Physiol. Res. 53: 235-243.
10. Zhu, X., J. S. Owen, M. D. Wilson, H. Li, G. L. Griffi ths, M. J. Thomas, E. M. Hiltbold, M. B. Fessler, and J. S. Parks. 2010. Macrophage ABCA1 reduces MyD88-dependent Toll-like receptor traffi cking to lipid rafts by reduction of lipid raft cholesterol. J. Lipid Res. 51: 3196 -3206.
11. Szabo, G., A. Dolganiuc, Q. Dai, and S. B. Pruett. 2007. TLR4, ethanol, and lipid rafts: a new mechanism of ethanol action with implications for other receptor-mediated effects. J. Immunol. 178: 1243-1249.
12. Olsson, S., and R. Sundler. 2006. The role of lipid rafts in LPSinduced signaling in a macrophage cell line. Mol. Immunol. 43: 607-612.
13. Triantafi lou, M., K. Miyake, D. T. Golenbock, and K. Triantafi lou. 2002. Mediators of innate immune recognition of bacteria concentrate in lipid rafts and facilitate lipopolysaccharide-induced cell activation. J. Cell Sci. 115: 2603-2611.
14. Wang, Q., M. Xia, C. Liu, H. Guo, Q. Ye, Y. Hu, Y. Zhang, M. Hou, H. Zhu, J. Ma, et al. 2008. Cyanidin-3-O-beta-glucoside inhibits iNOS and COX-2 expression by inducing liver X receptor a lpha activation in THP-1 macrophages. Life Sci. 83: 176-184.
15. Zhang, Y., F. Lian, Y. Zhu, M. Xia, Q. Wang, W. Ling, and X. D. Wang. 2010. Cyanidin-3-O-beta-glucoside inhibits LPS- induced expression of infl ammatory mediators through decreasing I kappa B alpha phosphorylation in THP-1 cells. Infl amm. Res. 59: 723-730.
16. Wang, D., M. Xia, S. Gao, D. Li, Y. Zhang, T. Jin, and W. Ling. 2012. Cyanidin-3-O-glucoside upregulates hepatic cholesterol 7-hydroxylase expression and reduces hypercholesterolemia in mice. Mol. Nutr. Food Res. 56: 610-621.
17. Wang, Y., Y. H. Zhang, X. M. Wang, Y. Liu, and M. Xia. 2012. Supplementation with cyanidin-3-O-glucoside protects against hypercholesterolemia-mediated endothelial dysfunction and attenuates atherosclerosis in apolipoprotein E-defi cient mice. J. Nutr. 142: 1033-1037.
18. Li, D., N. Zhang, Y. Cao, W. Zhang, G. Su, Y. Sun, Z. Liu, F. Li, D. Liang, B. Liu, et al. 2013. Emodin ameliorates lipopolysaccharideinduced mastitis in mice by inhibiti ng activation of NF-kappa B and MAPKs signal pathways. Eur. J. Pharmacol. 705: 79-85.
19. Kim, H. P., X. Wang, F. Galbiati, S. W. Ryter, and A. M. Choi. 2004. Caveolae compartmentalization of heme oxygenase-1 in endothelial cells. FASEB J. 18: 1080-1089.
20. Zhu, X., J. Y. Lee, J. M. Timmins, J. M. Brown, E. Boudyguina, A. Mulya, A. K. Gebre, M. C. Willingham, E. M. Hiltbold, N. Mishra, et al. 2008. Increased cellular free cholesterol in macrophage-specifi c Abca1 knock-out mice enhances pro-inflammatory response of macro phages. J. Biol. Chem. 283: 22930-22941.
21. Meng, G., Y. Liu, C. Lou, and H. Yang. 2010. Emodin suppresses lipopolysaccharide-induced pro-infl ammatory responses and NF-B activation by disrupting lipid rafts in CD14-negative endothelial cells. Br. J. Pharmacol. 161: 1628-1644.
22. Abate, W., A. A. Alghaithy, J. Parton, K. P. Jones, and S. K. Jackson. 2010. Surfactant lipids regulate LPS-induced interleukin-8 production in A549 lung epithelial cells by inhibiting translocation of TLR4 int o lipid raft domains. J. Lipid Res. 51: 334-344.
23. Nakahira, K., H. P. Kim, X. H. Geng, A. Nakao, X. Wang, N. Murase, P. F. Drain, X. Wang, M. Sasidhar, E. G. Nabel, et al. 20 06. Carbon monoxide differentially inhibits TLR signaling pathways by regulating ROS-induced traffi cking of TLRs to lipid rafts. J. Exp. Med. 203: 2377-2389.
24. Strandberg, Y., C. Gray, T. Vuocolo, L. Donaldson, M. Broadway, and R. Tellam. 2005. Lipopolysaccharide and lipoteichoic acid induce different innate immune responses in bovine mammary epithelial cells. Cytokine. 31: 72-86.
25. Gilbert, F. B., P. Cunha, K. Jensen, E. J. Glass, G. Foucras, C. Robert-Granié, R. Rupp, and P. Rainard. 2013. Differential response of bovine mammary epithelial cells to Staphylococcus aureus or Escherichia coli agonists of the innate immune system. Vet. Res. 44: 40.
26. Sordillo, L. M., and K. L. Streicher. 2002. Mammary gland immunity and mastitis susceptibility. J. Mammary Gland Biol. Neoplasia. 7: 135-146.
27. Zheng, J., A. D. Watson, and D. E. Kerr. 2006. Genome-wide expression analysis of lipopolysaccharide-induced mastitis in a mouse model. Infect. Immun. 74: 1907-1915.
28. Fernandez-Lizarbe, S., M. Pascual, M. S. Gascon, A. Blanco, and C. Guerri. 2008. Lipid rafts regulate ethanol-induced activation of TLR4 signaling in murine macrophages. Mol. Immunol. 45: 2007-2016.
29. Janowski, B. A., M. J. Grogan, S. A. Jones, G. B. Wisely, S. A. Kliewer, E. J. Corey, and D. J. Mangelsdorf. 1999. Structural requirements of ligands for the oxysterol liver X receptors LXRalpha a nd LXRbeta. Proc. Natl. Acad. Sci. USA. 96: 266-271.
30. Wang, N., M. Ranalletta, F. Matsuura, F. Peng, and A. R. Tall. 2006. LXR-induced redistribution of ABCG1 to plasma membrane in macrophages enhances cholesterol mass effl ux to HDL. Arterioscler. Thromb. Vasc. Biol. 26: 1310-1316.
31. Kennedy, M. A., G. C. Barrera, K. Nakamura, A. Baldan, P. Tarr, M. C. Fishbein, J. Frank, O. L. Francone, and P. A. Edwards. 2005. ABCG1 has a critical role in mediating cholesterol effl ux to HDL and preventing cellular lipid accumulation. Cell Metab. 1: 121-131.
32. Gelissen, I. C., M. Harris, K . A. Rye, C. Quinn, A. J. Brown, M. Kockx, S. Cartland, M. Packianathan, L. Kritharides, and W. Jessup. 2006. ABCA1 and ABCG1 synergize to mediate cholesterol export to apoA-I. Arterioscler. Thromb. Vasc. Biol. 26: 534-540.