Repair of DNA double-strand breaks by templated nucleotide sequence insertions derived from distant regions of the genome

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 21, 2014, Pages 7729-7734

  Onozawa, Masahiro ^a   Zhang, Zhenhua ^a   Kim, Yoo Jung ^a   Goldberg, Liat ^a   Varga, Tamas ^a   Bergsagel, P Leif ^b   Kuehl, W Michael ^a   Aplan, Peter D ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b MAYO CLINIC   (United States)

Author keywords

DNA patch; LINE 1; Polymorphism; TSIP

Indexed keywords

BRCA1 ASSOCIATED RING DOMAIN PROTEIN 1; DOUBLE STRANDED DNA; GENOMIC DNA; SPACER DNA;

ARTICLE; CELL PROLIFERATION; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; DNA REPAIR; DNA SEQUENCE; DNA STRAND BREAKAGE; EXON SHUFFLING; GENE DELETION; GENE INSERTION SEQUENCE; HUMAN; HUMAN CELL; HUMAN CHROMOSOME; HUMAN GENOME; IC 50; IN VIVO STUDY; INDEL MUTATION; LEUKEMIA CELL LINE; MOUSE; MYELOMA CELL; NONHUMAN; OVARIAN CANCER CELL LINE; PRIORITY JOURNAL; PROMOTER REGION; RETROPOSON; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TEMPLATED SEQUENCE INSERTION;

DNA PATCH; LINE-1; POLYMORPHISM; TSIP;

CELL LINE, TUMOR; CINNAMATES; COMPUTATIONAL BIOLOGY; DNA BREAKS, DOUBLE-STRANDED; DNA COPY NUMBER VARIATIONS; DNA PRIMERS; DNA REPAIR; GENETIC VECTORS; HUMANS; HYGROMYCIN B; MUTAGENESIS, INSERTIONAL; POLYMERASE CHAIN REACTION; RETROELEMENTS; TELOMERE;

EID: 84901649817     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1321889111     Document Type: Article

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