The susceptibility of Trypanosoma congolense and Trypanosoma brucei to isometamidium chloride and its synthetic impurities

Veterinary Parasitology

Volumn 203, Issue 3-4, 2014, Pages 270-275

  Sahin, Annelise ^a,c   Asencio, Corinne ^a   Izotte, Julien ^a   Pillay, Davita ^a   Coustou, Virginie ^a   Karembe, Hamadi ^b   Baltz, Théo ^a  

^a CNRS   (France)

^b CEVA SANTÉ ANIMALE   (France)

^c CNRS   (France)

Author keywords

Drug sensitivity; Isomers; Isometamidium; Trypanosoma

Indexed keywords

ANTITRYPANOSOMAL AGENT; ISOMETAMIDIUM CHLORIDE; ISOMETAMIDIUM DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROTOZOAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DOSAGE FORM COMPARISON; DRUG EFFECT; DRUG PURIFICATION; DRUG SENSITIVITY; DRUG SYNTHESIS; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IC 50; IN VITRO STUDY; IN VIVO STUDY; ISOMER; MOUSE; NONHUMAN; PROPHYLAXIS; TRYPANOCIDAL ACTIVITY; TRYPANOSOMA BRUCEI; TRYPANOSOMA CONGOLENSE; TRYPANOSOMIASIS;

ANIMALIA; BOS; MUS; TRYPANOSOMA; TRYPANOSOMA BRUCEI; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMA CONGOLENSE;

DRUG SENSITIVITY; ISOMERS; ISOMETAMIDIUM; TRYPANOSOMA;

ANIMALS; FEMALE; LETHAL DOSE 50; MICE; PARASITIC SENSITIVITY TESTS; PHENANTHRIDINES; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMA CONGOLENSE; TRYPANOSOMIASIS;

EID: 84901623673     PISSN: 03044017     EISSN: 18732550     Source Type: Journal    
DOI: 10.1016/j.vetpar.2014.04.002     Document Type: Article

References (18)

1. Baltz T., Baltz D., Giroud C., Crockett J. Cultivation in a semi-defined medium of animal infective forms of Trypanosoma brucei, T. equiperdum, T. evansi, T. rhodesiense and T. gambiense. EMBO J. 1985, 4:1273-1277.
2. Berg S.S. The search for new trypanocides. Part VIII. Coupling of m-amidinobenzenediazonium chloride with 3,8-diamino-5-ethyl-6-phenylphenanthridinium chloride. J. Chem. Soc. (Resumed) 1963, 684:3635-3640.
3. Boibessot I., Turner C.M., Watson D.G., Goldie E., Connel G., McIntosh A., Grant M.H., Skellern G.G. Metabolism and distribution of phenanthridine trypanocides in Trypanosoma brucei. Acta Trop. 2002, 84:219-228.
4. Brown K.N., Hill J., Holland A.E. Anti-trypanosomal activity of certain phenyldiazoamino- and phenylazoamino-phenanthridinium compounds. Br. J. Pharmacol. Chemother. 1961, 17:396-405.
5. Coustou V., Guegan F., Plazolles N., Baltz T. Complete in vitro life cycle of Trypanosoma congolense: development of genetic tools. PLoS Negl. Trop. Dis. 2010, 4:e618.
6. Delespaux V., Geysen D., Van den Bossche P., Geerts S. Molecular tools for the rapid detection of drug resistance in animal trypanosomes. Trends Parasitol. 2008, 24:236-242.
7. Diarra B., Diall O., Geerts S., Kageruka P., Lemmouchi Y., Schacht E., Eisler M.C., Holmes P. Field evaluation of the prophylactic effect of an isometamidium sustained-release device against trypanosomiasis in cattle. Antimicrob. Agents Chemother. 1998, 42:1012-1014.
8. Eisler M.C., Brandt J., Bauer B., Clausen P.H., Delespaux V., Holmes P.H., Ilemobade A., Machila N., Mbwambo H., McDermott J., Mehlitz D., Murilla G., Ndung'u J.M., Peregrine A.S., Sidibe I., Sinyangwe L., Geerts S. Standardised tests in mice and cattle for the detection of drug resistance in tsetse-transmitted trypanosomes of African domestic cattle. Vet. Parasitol. 2001, 97:171-182.
9. Gray M.A., Kimarua R.W., Peregrine A.S., Stevenson P. Drug sensitivity screening in vitro of populations of Trypanosoma congolense originating from cattle and tsetse flies at Nguruman, Kenya. Acta Trop. 1993, 55:1-9.
10. Gray M.A., Peregrine A.S. An in vitro assay for drug sensitivity of Trypanosoma congolense using in vitro-derived metacyclic trypanosomes. Acta Trop. 1993, 54:291-300.
11. Hirumi H. Axenic culture of Trypanosoma congolense: application to the detection of sensitivity levels of bloodstream trypomastigotes to diminazene aceturate, homidium chloride, isometamidium chloride and quinapyramine sulphate. J. Protozool. Res. 1993, 3:52-63.
12. Kaminsky R., Schmid C., Lun Z.R. Susceptibility of dyskinetoplastic Trypanosoma evansi and T. equiperdum to isometamidium chloride. Parasitol. Res. 1997, 83:816-818.
13. Kinabo L.D., Bogan J.A. The pharmacology of isometamidium. J. Vet. Pharmacol. Ther. 1988, 11:233-245.
14. Peregrine A.S., Ogunyemi O., Whitelaw D.D., Holmes P.H., Moloo S.K., Hirumi H., Urquhart G.M., Murray M. Factors influencing the duration of isometamidium chloride (Samorin) prophylaxis against experimental challenge with metacyclic forms of Trypanosoma congolense. Vet. Parasitol. 1988, 28:53-64.
15. Schad G.J., Allanson A., Mackay S.P., Cannavan A., Tettey J.N. Development and validation of an improved HPLC method for the control of potentially counterfeit isometamidium products. J. Pharm. Biomed. Anal. 2008, 46:45-51.
16. Tettey J.N., Skellern G.G., Grant M.H., Midgley J.M. Investigation of the chemical equivalence of the trypanocidal products, Samorin and Veridium. J. Pharm. Biomed. Anal. 1999, 21:1-7.
17. Tielens A.G., van Hellemond J.J. Surprising variety in energy metabolism within Trypanosomatidae. Trends Parasitol. 2009, 25:482-490.
18. Wilkes J.M., Mulugeta W., Wells C., Peregrine A.S. Modulation of mitochondrial electrical potential: a candidate mechanism for drug resistance in African trypanosomes. Biochem. J. 1997, 326(Pt 3):755-761.