The effect of beta-elemene on alpha-tubulin polymerization in human hepatoma HepG2 cells

Chinese Journal of Cancer Research

Volumn 25, Issue 6, 2013, Pages 770-776

  Zhang, Jielin ^a   Mao, Yuqiu ^a   Hou, Li ^a   Cui, Xiaonan ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

Alpha tubulin; Beta elemene injection; Hepatocellular carcinoma (hcc); Microtubules; Tubulin polymerization

Indexed keywords

ALPHA TUBULIN; BETA ELEMENE; MESSENGER RNA;

ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; FLOW CYTOMETRY; HEPG2 CELL LINE; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; MICROTUBULE; MTT ASSAY; POLYMERIZATION; PROTEIN CONTENT; PROTEIN EXPRESSION; S PHASE CELL CYCLE CHECKPOINT;

EID: 84901612033     PISSN: 10009604     EISSN: 19930631     Source Type: Journal    
DOI: 10.3978/j.issn.1000-9604.2013.12.12     Document Type: Article

References (28)

1. McGlynn KA, London WT. The global epidemiology of hepatocellular carcinoma: present and future. Clin Liver Dis 2011;15:223-43, vii-x.
2. Cabrera R, Limaye AR, Horne P, et al. The anti-viral effect of sorafenib in hepatitis C-related hepatocellular carcinoma. Aliment Pharmacol Ther 2013;37:91-7.
3. Sun Y, Lu XX, Cui XN, et al. Impact of Cinobufacini injection on proliferation and cell cycle of human hepatoma HepG-2 cells. Chinese-German Journal of Clinical Oncology 2011;10:321-4.
4. Sun Y, Shi YK. eds. Clinical tumor medicine manual. 5th ed. Peking: People Health Publisher, 2007;539-49.
5. Llovet JM, Ricci S, Mazzaferro V, et al. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 2008;359:378-90.
6. Cheng AL, Kang YK, Chen Z, et al. Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial. Lancet Oncol 2009;10:25-34.
7. Yang FQ, Li SP, Chen Y, et al. Identification and quantitation of eleven sesquiterpenes in three species of Curcuma rhizomes by pressurized liquid extraction and gas chromatography-mass spectrometry. J Pharm Biomed Anal 2005;39:552-8. (Pubitemid 41196062)
8. Zhou X, Li Z, Liang G, et al. Analysis of volatile components of Curcuma sichuanensis X. X. Chen by gas chromatography-mass spectrometry. J Pharm Biomed Anal 2007;43:440-4. (Pubitemid 44960553)
9. Zhang HY, Hu CX, Liu CP, et al. Screening and analysis of bioactive compounds in traditional Chinese medicines using cell extract and gas chromatography-mass spectrometry. J Pharm Biomed Anal 2007;43:151-7. (Pubitemid 44856207)
10. Li X, Wang G, Zhao J, et al. Antiproliferative effect of beta-elemene in chemoresistant ovarian carcinoma cells is mediated through arrest of the cell cycle at the G2-M phase. Cell Mol Life Sci 2005;62:894-904. (Pubitemid 40655636)
11. Wang G, Li X, Huang F, et al. Antitumor effect of beta-elemene in non-small-cell lung cancer cells is mediated via induction of cell cycle arrest and apoptotic cell death. Cell Mol Life Sci 2005;62:881-93. (Pubitemid 40655635)
12. Tao L, Zhou L, Zheng L, et al. Elemene displays anticancer ability on laryngeal cancer cells in vitro and in vivo. Cancer Chemother Pharmacol 2006;58:24-34.
13. Chen Z, Song Y, Che J, et al. Validation of a sensitive gas chromatographic-mass spectrometric method for the simultaneous determination of beta-elemene and beta-elemenal in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci 2009;877:408-14.
14. Peng X, Zhao Y, Liang X, et al. Assessing the quality of RCTs on the effect of beta-elemene, one ingredient of a Chinese herb, against malignant tumors. Contemp Clin Trials 2006;27:70-82. (Pubitemid 41758440)
15. Sun Y, Liu G, Zhang Y, et al. Synthesis and in vitro antiproliferative activity of beta-elemene monosubstituted derivatives in HeLa cells mediated through arrest of cell cycle at the G1 phase. Bioorg Med Chem 2009;17:1118-24.
16. Xu L, Tao S, Wang X, et al. The synthesis and anti-proliferative effects of beta-elemene derivatives with mTOR inhibition activity. Bioorg Med Chem 2006;14:5351-6. (Pubitemid 43922417)
17. Górka M, Daniewski WM, Gajkowska B, et al. Autophagy is the dominant type of programmed cell death in breast cancer MCF-7 cells exposed to AGS 115 and EFDAC, new sesquiterpene analogs of paclitaxel. Anticancer Drugs 2005;16:777-88. (Pubitemid 41104929)
18. Nicholson B, Lloyd GK, Miller BR, et al. NPI-2358 is a tubulin-depolymerizing agent: in-vitro evidence for activity as a tumor vascular-disrupting agent. Anticancer Drugs 2006;17:25-31.
19. Kavallaris M, Tait AS, Walsh BJ, et al. Multiple microtubule alterations are associated with Vinca alkaloid resistance in human leukemia cells. Cancer Res 2001;61:5803-9. (Pubitemid 32769098)
20. Fu NW. Antitumor effect and pharmacological actions of beta-elemene isolated from the rhizome of Curcuma aromatica. Zhong Yao Tong Bao 1984;9:83-7.
21. Tan P, Zhong W, Cai W. Clinical study on treatment of 40 cases of malignant brain tumor by elemene emulsion injection. Zhongguo Zhong Xi Yi Jie He Za Zhi 2000;20:645-8.
22. Wang J, Zhang H, Sun Y. Phase III clinical trial of elemenum emulsion in the management of malignant pleural and peritoneal effusions. Zhonghua Zhong Liu Za Zhi 1996;18:464-7.
23. Hu J, Jin W, Yang PM. Reversal of resistance to adriamycin in human breast cancer cell line MCF-7/ADM by beta-elemene. Zhonghua Zhong Liu Za Zhi 2004;26:268-70.
24. Wu W, Liu K, Tang X. Preliminary study on the antitumor immuno-protective mechanism of beta-elemene. Zhonghua Zhong Liu Za Zhi 1999;21:405-8.
25. Wang L, Yang YJ, Chen SH, et al. Effects of beta-sitosterol on microtubular systems in cervical cancer cells. Zhonghua Yi Xue Za Zhi 2006;86:2771-5. (Pubitemid 46020149)
26. Davis A, Jiang JD, Middleton KM, et al. Novel suicide ligands of tubulin arrest cancer cells in S-phase. Neoplasia 1999;1:498-507.
27. Jiang JD, Denner L, Ling YH, et al. Double blockade of cell cycle at g(1)-s transition and m phase by 3-iodoacetamido benzoyl ethyl ester, a new type of tubulin ligand. Cancer Res 2002;62:6080-8. (Pubitemid 35244456)
28. Pedro M, Ferreira MM, Cidade H, et al. Artelastin is a cytotoxic prenylated flavone that disturbs microtubules and interferes with DNA replication in MCF-7 human breast cancer cells. Life Sci 2005;77:293-311. (Pubitemid 40692869)