Targeted profiling of polar intracellular metabolites using ion-pair-high performance liquid chromatography and -ultra high performance liquid chromatography coupled to tandem mass spectrometry: Applications to serum, urine and tissue extracts

Journal of Chromatography A

Volumn 1349, Issue , 2014, Pages 60-68

  Michopoulos, Filippos ^a,b   Whalley, Nicky ^a   Theodoridis, Georgios ^b   Wilson, Ian D ^c   Dunkley, Tom P J ^a   Critchlow, Susan E ^a  

^a Oncology iMED   (United Kingdom)

^b ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Central carbon metabolism; HILIC; Ion pair chromatography; Mass spectrometry; Metabolite profiling; Porous graphitic carbon

Indexed keywords

BIOMOLECULES; BODY FLUIDS; CARBON; CELL CULTURE; CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MATRIX ALGEBRA; METABOLISM; METABOLITES; PHYSIOLOGY; POROUS MATERIALS; TISSUE;

CENTRAL CARBON METABOLISMS; HILIC; ION-PAIR CHROMATOGRAPHY; METABOLITE PROFILING; POROUS GRAPHITIC CARBON;

TISSUE ENGINEERING;

CARBON; CARBOXYLIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD ANALYSIS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; HYDROPHILIC INTERACTION CHROMATOGRAPHY; IN VITRO STUDY; INTERMETHOD COMPARISON; ION PAIR CHROMATOGRAPHY; ION PAIR HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIMIT OF DETECTION; LIMIT OF QUANTITATION; MALE; METABOLITE; MOUSE; NONHUMAN; PHOSPHORYLATION; POROSITY; PRIORITY JOURNAL; REPRODUCIBILITY; SEPARATION TECHNIQUE; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; URINALYSIS;

CENTRAL CARBON METABOLISM; HILIC; ION PAIR CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITE PROFILING; POROUS GRAPHITIC CARBON;

CARBON; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLINICAL CHEMISTRY TESTS; DRUG CONTAMINATION; HUMANS; INTRACELLULAR SPACE; METABOLOME; PLASMA; TANDEM MASS SPECTROMETRY; TISSUE EXTRACTS; URINE;

EID: 84901606587     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2014.05.019     Document Type: Article

References (24)

1. Cantor J.R., Sabatini D.M. Cancer Discov. 2012, 2:881.
2. Vander Heiden M.G. Nat. Rev. Drug Discov. 2011, 10:671.
3. Tennant D.A., Duran R.V., Gottlieb E. Nat. Rev. Cancer 2010, 10:267.
4. Kroemer G., Pouyssegur J. Cancer Cell 2008, 13:472.
5. Theodoridis G.A., Gika H.G., Want E.J., Wilson I.D. Anal. Chim. Acta 2012, 711:7.
6. Ewald J.C., Heux S., Zamboni N. Anal. Chem. 2009, 81:3623.
7. Gika H.G., Theodoridis G.A., Vrhovsek U., Mattivi F. J. Chromatogr. A 2012, 1259:121.
8. Schiesel S., Lämmerhofer M., Lindner W. Anal. Bioanal. Chem. 2010, 396:1655.
9. Preinerstorfer B., Schiesel S., Lämmerhofer M., Lindner W. J. Chromatogr. A 2010, 1217:312.
10. Buescher J.M., Czernik D., Ewald J.C., Sauer U., Zamboni N. Anal. Chem. 2009, 81:2135.
11. Luo B., Groenke K., Takors R., Wandrey C., Oldiges M. J. Chromatogr. A 2007, 1147:153.
12. Coulier L., Bas R., Jespersen S., Verheij E., van d.W., Hankemeier T. Anal. Chem. 2006, 78:6573.
13. Buescher J.M., Moco S., Sauer U., Zamboni N. Anal. Chem. 2010, 82:4403.
14. Lu W., Clasquin M.F., Melamud E., Amador-Noguez D., Caudy A.A., Rabinowitz J.D. Anal. Chem. 2010, 82:3212.
15. Bennette N.B., Eng J.F., Dismukes G.C. Anal. Chem. 2011, 83:3808.
16. Balcke G.U., Kolle S.N., Kamp H., Bethan B., Looser R., Wagner S., Landsiedel R., van Ravenzwaay B. Toxicol. Lett. 2011, 203:200.
17. Kiefer P., Delmotte N., Vorholt J.A. Anal. Chem. 2011, 83:850.
18. Siegel D., Permentier H., Bischoff R. J. Chromatogr. A 2013, 1294:87.
19. Pabst M., Grass J., Fischl R., Leònard R., Jin C., Hinterkörner G., Borth N., Altmann F. Anal. Chem. 2010, 82:9782.
20. Antonio C., Larson T., Gilday A., Graham I., Bergström E., Thomas-Oates J. J. Chromatogr. A 2007, 1172:170.
21. Yoshikawa K., Okamura M., Inokuchi M., Sakuragawa A. Talanta 2007, 72:305.
22. Asakawa Y., Tokida N., Ozawa C., Ishiba M., Tagaya O., Asakawa N. J. Chromatogr. A 2008, 1198/1199:80.
23. Gika H.G., Theodoridis G.A., Wingate J.E., Wilson I.D. J. Proteome Res. 2007, 6:3291.
24. Michopoulos F., Lai L., Gika H., Theodoridis G., Wilson I. J. Proteome Res. 2009, 8:2114.