-
1
-
-
2442482962
-
Key factors in the rising cost of new drug discovery and development
-
Dickson M, Gagnon JP. Key factors in the rising cost of new drug discovery and development. Nat Rev Drug Discov 2004;3:417-29. (Pubitemid 38618124)
-
(2004)
Nature Reviews Drug Discovery
, vol.3
, Issue.5
, pp. 417-429
-
-
Dickson, M.1
Gagnon, J.P.2
-
2
-
-
84863174358
-
'Old drugs for new applications': Can orthopedic research benefit from this strategy?
-
Pan X, Cheng W, Wang J, et al. 'Old drugs for new applications': can orthopedic research benefit from this strategy? Ther Adv Musculoskel Dis 2011;3:201-5.
-
(2011)
Ther Adv Musculoskel Dis
, vol.3
, pp. 201-205
-
-
Pan, X.1
Cheng, W.2
Wang, J.3
-
5
-
-
84874740027
-
The molecular mechanism of action of aspirin, curcumin and sulforaphane combinations in the chemoprevention of pancreatic cancer
-
Thakkar A, Sutaria D, Grandhi BK, et al. The molecular mechanism of action of aspirin, curcumin and sulforaphane combinations in the chemoprevention of pancreatic cancer. Oncol Rep 2013;29:1671-7.
-
(2013)
Oncol Rep
, vol.29
, pp. 1671-1677
-
-
Thakkar, A.1
Sutaria, D.2
Grandhi, B.K.3
-
6
-
-
84880349109
-
Enhanced Anti-tumor Efficacy of Aspirin Combined with Triptolide in Cervical Cancer Cells
-
Chen RH, Tian YJ. Enhanced Anti-tumor Efficacy of Aspirin Combined with Triptolide in Cervical Cancer Cells. Asian Pac J Cancer Prev 2013;14:3041-4.
-
(2013)
Asian Pac J Cancer Prev
, vol.14
, pp. 3041-3044
-
-
Chen, R.H.1
Tian, Y.J.2
-
7
-
-
74049139484
-
Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression
-
Zhang H, Wei J, Xue R, et al. Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression. Metabolism 2010;59:285-92.
-
(2010)
Metabolism
, vol.59
, pp. 285-292
-
-
Zhang, H.1
Wei, J.2
Xue, R.3
-
8
-
-
84882447813
-
Modulation of the expression of folate cycle enzymes and polyamine metabolism by berberine in cisplatin-sensitive and -resistant human ovarian cancer cells
-
Marverti G, Ligabue A, Lombardi P, et al. Modulation of the expression of folate cycle enzymes and polyamine metabolism by berberine in cisplatin-sensitive and -resistant human ovarian cancer cells. Int J Oncol 2013;43:1269-80.
-
(2013)
Int J Oncol
, vol.43
, pp. 1269-1280
-
-
Marverti, G.1
Ligabue, A.2
Lombardi, P.3
-
9
-
-
79961192394
-
Berberine Radiosensitizes Human Esophageal Cancer Cells by Downregulating Homologous Recombination Repair Protein RAD51
-
Liu Q, Jiang H, Liu Z, et al. Berberine Radiosensitizes Human Esophageal Cancer Cells by Downregulating Homologous Recombination Repair Protein RAD51. PLoS One 2011;6:e23427.
-
(2011)
PLoS One
, vol.6
-
-
Liu, Q.1
Jiang, H.2
Liu, Z.3
-
10
-
-
84858279403
-
Pharmacological ascorbate induces cytotoxicity in prostate cancer cells through ATP depletion and induction of autophagy
-
Chen P, Yu J, Chalmers B, et al. Pharmacological ascorbate induces cytotoxicity in prostate cancer cells through ATP depletion and induction of autophagy. Anticancer Drugs 2012;23:437-44.
-
(2012)
Anticancer Drugs
, vol.23
, pp. 437-444
-
-
Chen, P.1
Yu, J.2
Chalmers, B.3
-
11
-
-
70350337093
-
Vitamin C: Update on physiology and pharmacology
-
Mandl J, Szarka A, Bánhegyi G. Vitamin C: update on physiology and pharmacology. Br J Pharmacol 2009;157:1097-110.
-
(2009)
Br J Pharmacol
, vol.157
, pp. 1097-1110
-
-
Mandl, J.1
Szarka, A.2
Bánhegyi, G.3
-
12
-
-
84884180333
-
The effects of high concentrations of vitamin C on cancer cells
-
Park S. The effects of high concentrations of vitamin C on cancer cells. Nutrients 2013;5:3496-505.
-
(2013)
Nutrients
, vol.5
, pp. 3496-3505
-
-
Park, S.1
-
13
-
-
73049112178
-
Vitamin C enhances the generation of mouse and human induced pluripotent stem cells
-
Esteban MA, Wang T, Qin B, et al. Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. Cell Stem Cell 2010;6:71-9.
-
(2010)
Cell Stem Cell
, vol.6
, pp. 71-79
-
-
Esteban, M.A.1
Wang, T.2
Qin, B.3
-
14
-
-
82755187396
-
The histone demethylases Jhdm1a/1b enhance somatic cell reprogramming in a vitamin-C-dependent manner
-
Wang T, Chen K, Zeng X, et al. The histone demethylases Jhdm1a/1b enhance somatic cell reprogramming in a vitamin-C-dependent manner. Cell Stem Cell 2011;9:575-87.
-
(2011)
Cell Stem Cell
, vol.9
, pp. 575-587
-
-
Wang, T.1
Chen, K.2
Zeng, X.3
-
16
-
-
0019508909
-
Arrest of in vivo proliferation of Zajdela tumor cells by inhibition of mitochondrial protein synthesis
-
van den Bogert C, Dontje BH, Wybenga JJ, et al. Arrest of in vivo proliferation of Zajdela tumor cells by inhibition of mitochondrial protein synthesis. Cancer Res 1981;41:1943-7. (Pubitemid 11114601)
-
(1981)
Cancer Research
, vol.41
, Issue.5
, pp. 1943-1947
-
-
Van Den, B.C.1
Dontje, B.H.J.2
Wybenga, J.J.3
Kroon, A.M.4
-
17
-
-
77953380234
-
Acute propafenone toxicity after two exposures at standard dosing
-
Yeung A, Shanks D, Parwana H, et al. Acute propafenone toxicity after two exposures at standard dosing. Can J Cardiol 2010;26:209-10.
-
(2010)
Can J Cardiol
, vol.26
, pp. 209-210
-
-
Yeung, A.1
Shanks, D.2
Parwana, H.3
-
18
-
-
33947596046
-
Update on the role of non-opioids for postoperative pain treatment
-
DOI 10.1016/j.bpa.2006.12.002, PII S1521689606000838
-
Schug SA, Manopas A. Update on the role of non-opioids for postoperative pain treatment. Best Pract Res Clin Anaesthesiol 2007;21:15-30. (Pubitemid 46478025)
-
(2007)
Best Practice and Research in Clinical Anaesthesiology
, vol.21
, Issue.1
, pp. 15-30
-
-
Schug, S.A.1
Manopas, A.2
-
19
-
-
78751684510
-
Comparison of dipyrone/propofol versus fentanyl/propofol anaesthesia during surgery in rabbits
-
Baumgartner C, Koenighaus H, Ebner J, et al. Comparison of dipyrone/propofol versus fentanyl/propofol anaesthesia during surgery in rabbits. Lab Anim 2011;45:38-44.
-
(2011)
Lab Anim
, vol.45
, pp. 38-44
-
-
Baumgartner, C.1
Koenighaus, H.2
Ebner, J.3
-
20
-
-
84874941515
-
Novel chiral ferrocenylpyrazolo[1,5-a][1,4]diazepin-4-one derivatives-synthesis, characterization and inhibition against lung cancer cells
-
Shen SL, Shao JH, Luo JZ, et al. Novel chiral ferrocenylpyrazolo[1,5-a] [1,4]diazepin-4-one derivatives-synthesis, characterization and inhibition against lung cancer cells. Eur J Med Chem 2013;63:256-68.
-
(2013)
Eur J Med Chem
, vol.63
, pp. 256-268
-
-
Shen, S.L.1
Shao, J.H.2
Luo, J.Z.3
-
21
-
-
0025341331
-
New colorimetric cytotoxicity assay for anticancer-drug screening
-
Skehan P, Storeng R, Scudiero D, et al. New colorimetric cytotoxicity assay for anticancer-drug screening. J Natl Cancer Inst 1990;82:1107-12. (Pubitemid 20213250)
-
(1990)
Journal of the National Cancer Institute
, vol.82
, Issue.13
, pp. 1107-1112
-
-
Skehan, P.1
Storeng, R.2
Scudiero, D.3
Monks, A.4
McMahon, J.5
Vistica, D.6
Warren, J.T.7
Bokesch, H.8
Kenney, S.9
Boyd, M.R.10
-
22
-
-
0025367455
-
Comparison of in vitro anticancer-drug-screening data generated with a tetrazolium assay versus a protein assay against a diverse panel of human tumor cell lines
-
Rubinstein LV, Shoemaker RH, Paull KD, et al. Comparison of in vitro anticancer -drug-screening data generated with a tetrazolium assay versus a protein assay against a diverse panel of human tumor cell lines. J Natl Cancer Inst 1990;82:1113-8. (Pubitemid 20213251)
-
(1990)
Journal of the National Cancer Institute
, vol.82
, Issue.13
, pp. 1113-1118
-
-
Rubinstein, L.V.1
Shoemaker, R.H.2
Paull, K.D.3
Simon, R.M.4
Tosini, S.5
Skehan, P.6
Scudiero, D.A.7
Monks, A.8
Boyd, M.R.9
-
23
-
-
16444381759
-
Overexpression of soluble TRAIL induces apoptosis in human lung adenocarcinoma and inhibits growth of tumor xenografts in nude mice
-
DOI 10.1158/0008-5472.CAN-04-2749
-
Shi J, Zheng D, Liu Y, et al. Overexpression of soluble TRAIL induces apoptosis in human lung adenocarcinoma and inhibits growth of tumor xenografts in nude mice. Cancer Res 2005;65:1687-92. (Pubitemid 40478593)
-
(2005)
Cancer Research
, vol.65
, Issue.5
, pp. 1687-1692
-
-
Shi, J.1
Zheng, D.2
Liu, Y.3
Mai, H.S.4
Tam, P.5
Farzaneh, F.6
Xu, R.7
-
24
-
-
49849090945
-
Human alpha-defensin-1 inhibits growth of human lung adenocarcinoma xenograft in nude mice
-
Xu N, Wang YS, Pan WB, et al. Human alpha-defensin-1 inhibits growth of human lung adenocarcinoma xenograft in nude mice. Mol Cancer Ther 2008;7:1588-97.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 1588-1597
-
-
Xu, N.1
Wang, Y.S.2
Pan, W.B.3
-
25
-
-
79955631860
-
Microwave-assisted synthesis, crystal structure of pyrazolo[1,5-a] pyrazin-4(5H)-ones and their selective effects on lung cancer cells
-
Liu N, Zhang JH, Zhao BX, et al. Microwave-assisted synthesis, crystal structure of pyrazolo[1,5-a]pyrazin-4(5H)-ones and their selective effects on lung cancer cells. Eur J Med Chem 2011;46:2359-67.
-
(2011)
Eur J Med Chem
, vol.46
, pp. 2359-2367
-
-
Liu, N.1
Zhang, J.H.2
Zhao, B.X.3
-
26
-
-
0029814162
-
Overexpression of heme oxygenase-1 in human pulmonary epithelial cells results in cell growth arrest and increased resistance to hyperoxia
-
DOI 10.1073/pnas.93.19.10393
-
Lee PJ, Alam J, Wiegand GW, et al. Overexpression of heme oxygenase-1 in human pulmonary epithelial cells results in cell growth arrest and increased resistance to hyperoxia. Proc Natl Acad Sci U S A 1996;93:10393-8. (Pubitemid 26314633)
-
(1996)
Proceedings of the National Academy of Sciences of the United States of America
, vol.93
, Issue.19
, pp. 10393-10398
-
-
Lee, P.J.1
Alam, J.2
Wiegand, G.W.3
Choi, A.M.K.4
-
27
-
-
0032168201
-
2/M
-
Lee JY, Leonhardt LG, Obeid LM. Cell-cycle-dependent changes in ceramide levels preceding retinoblastoma protein dephosphorylation in G2/M. Biochem J 1998;334:457-61. (Pubitemid 28448590)
-
(1998)
Biochemical Journal
, vol.334
, Issue.2
, pp. 457-461
-
-
Lee, J.Y.1
Leonhardt, L.G.2
Obeid, L.M.3
-
28
-
-
0017184389
-
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
-
Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248-54.
-
(1976)
Anal Biochem
, vol.72
, pp. 248-254
-
-
Bradford, M.M.1
-
29
-
-
71749114878
-
Synthesis and discovery of pyrazole-5 -carbohydrazide N-glycosides as inducer of autophagy in A549 lung cancer cells
-
Lian S, Su H, Zhao BX, et al. Synthesis and discovery of pyrazole-5 -carbohydrazide N-glycosides as inducer of autophagy in A549 lung cancer cells. Bioorg Med Chem 2009;17:7085-92.
-
(2009)
Bioorg Med Chem
, vol.17
, pp. 7085-7092
-
-
Lian, S.1
Su, H.2
Zhao, B.X.3
-
30
-
-
0017654312
-
Chromosome analysis and alkaline phosphatase of C4I, a cell line of human cervical origin distinct from HeLa
-
Herz F, Miller OJ, Miller DA, et al. Chromosome analysis and alkaline phosphatase of C41, a cell line of human cervical origin distinct from HeLa. Cancer Res 1977;37:3209-13. (Pubitemid 8169980)
-
(1977)
Cancer Research
, vol.37
, Issue.9
, pp. 3209-3213
-
-
Herz, F.1
Miller, O.J.2
Miller, D.A.3
-
31
-
-
77349126542
-
Oral cancer overexpressed 1 (ORAOV1) regulates cell cycle and apoptosis in cervical cancer HeLa cells
-
Jiang L, Zeng X, Wang Z, et al. Oral cancer overexpressed 1 (ORAOV1) regulates cell cycle and apoptosis in cervical cancer HeLa cells. Mol Cancer 2010;9:20-8.
-
(2010)
Mol Cancer
, vol.9
, pp. 20-28
-
-
Jiang, L.1
Zeng, X.2
Wang, Z.3
-
32
-
-
41349099104
-
Cancer statistics, 2008
-
DOI 10.3322/CA.2007.0010
-
Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2008. CA Cancer J Clin 2008;58:71-96. (Pubitemid 351521864)
-
(2008)
CA Cancer Journal for Clinicians
, vol.58
, Issue.2
, pp. 71-96
-
-
Jemal, A.1
Siegel, R.2
Ward, E.3
Hao, Y.4
Xu, J.5
Murray, T.6
Thun, M.J.7
-
33
-
-
79958753893
-
Synthesis of novel pyrazolo[1,5-a]pyrazin-4(5H)-one derivatives and their inhibition against growth of A549 and H322 lung cancer cells
-
Zheng LW, Shao JH, Zhao BX, et al. Synthesis of novel pyrazolo[1,5-a]pyrazin-4(5H)-one derivatives and their inhibition against growth of A549 and H322 lung cancer cells. Bioorg Med Chem Lett 2011;21:3909-13.
-
(2011)
Bioorg Med Chem Lett
, vol.21
, pp. 3909-3913
-
-
Zheng, L.W.1
Shao, J.H.2
Zhao, B.X.3
-
34
-
-
36849068883
-
Induction of apoptotic cell death by synthetic naringenin derivatives in human lung epithelial carcinoma A549 cells
-
Lee ER, Kang YJ, Choi HY, et al. Induction of apoptotic cell death by synthetic naringenin derivatives in human lung epithelial carcinoma A549 cells. Biol Pharm Bull 2007;30:2394-8.
-
(2007)
Biol Pharm Bull
, vol.30
, pp. 2394-2398
-
-
Lee, E.R.1
Kang, Y.J.2
Choi, H.Y.3
-
35
-
-
84863756423
-
Surf the Post-translational Modification Network of p53 Regulation
-
Gu B, Zhu WG. Surf the Post-translational Modification Network of p53 Regulation. Int J Biol Sci 2012;8:672-84.
-
(2012)
Int J Biol Sci
, vol.8
, pp. 672-684
-
-
Gu, B.1
Zhu, W.G.2
-
36
-
-
38949108670
-
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
-
Klionsky DJ, Abeliovich H, Agostinis P, et al. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 2008;4:151-75. (Pubitemid 351231180)
-
(2008)
Autophagy
, vol.4
, Issue.2
, pp. 151-175
-
-
Klionsky, D.J.1
Abeliovich, H.2
Agostinis, P.3
Agrawal, D.K.4
Aliev, G.5
Askew, D.S.6
Baba, M.7
Baehrecke, E.H.8
Bahr, B.A.9
Ballabio, A.10
Bamber, B.A.11
Bassham, D.C.12
Bergamini, E.13
Bi, X.14
Biard-Piechaczyk, M.15
Blum, J.S.16
Bredesen, D.E.17
Brodsky, J.L.18
Brumell, J.H.19
Brunk, U.T.20
Bursch, W.21
Camougrand, N.22
Cebollero, E.23
Cecconi, F.24
Chen, Y.25
Chin, L.-S.26
Choi, A.27
Chu, C.T.28
Chung, J.29
Clarke, P.G.H.30
Clark, R.S.B.31
Clarke, S.G.32
Clave, C.33
Cleveland, J.L.34
Codogno, P.35
Colombo, M.I.36
Cotomontes, A.37
Cregg, J.M.38
Cuervo, A.M.39
Debnath, J.40
Demarchi, F.41
Dennis, P.B.42
Dennis, P.A.43
Deretic, V.44
Devenish, R.J.45
Di, S.F.46
Dice, J.F.47
DiFiglia, M.48
Dinesh-Kumar, S.49
Distelhorst, C.W.50
Djavaheri-Mergny, M.51
Dorsey, F.C.52
Droge, W.53
Dron, M.54
Dunn Jr., W.A.55
Duszenko, M.56
Eissa, N.T.57
Elazar, Z.58
Esclatine, A.59
Eskelinen, E.-L.60
Fesus, L.61
Finley, K.D.62
Fuentes, J.M.63
Fueyo, J.64
Fujisaki, K.65
Galliot, B.66
Gao, F.-B.67
Gewirtz, D.A.68
Gibson, S.B.69
Gohla, A.70
Goldberg, A.L.71
Gonzalez, R.72
Gonzalez-Estevez, C.73
Gorski, S.74
Gottlieb, R.A.75
Haussinger, D.76
He, Y.-W.77
Heidenreich, K.78
Hill, J.A.79
Hoyer-Hansen, M.80
Hu, X.81
Huang, W.-P.82
Iwasaki, A.83
Jaattela, M.84
Jackson, W.T.85
Jiang, X.86
Jin, S.87
Johansen, T.88
Jung, J.U.89
Kadowaki, M.90
Kang, C.91
Kelekar, A.92
Kessel, D.H.93
Kiel, J.A.K.W.94
Hong, P.K.95
Kimchi, A.96
Kinsella, T.J.97
Kiselyov, K.98
Kitamoto, K.99
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