Pinostrobin and Cajanus lactone isolated from Cajanus cajan (L.) leaves inhibits TNF-α and IL-1β production: In vitro and in vivo experimentation

Phytomedicine

Volumn 21, Issue 7, 2014, Pages 946-953

  Patel, Neeraj K ^a   Bhutani, Kamlesh K ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

Cajanus cajan; Cajanus lactone; Interleukin 1 ; Pinostrobin; Stilbenes; tumor necrosis factor

Indexed keywords

7 METHYL GLABRANIN; 7,4 DIMETHOXY FLAVANONE; ACETIC ACID ETHYL ESTER; ANTIINFLAMMATORY AGENT; BUTANOL; CAJANUS LACTONE; CURCUMIN; DEXAMETHASONE; GENISTEIN 8 C BETA DEXTRO GLUCOSIDE; HERBACEOUS AGENT; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA INHIBITOR; LIPOPOLYSACCHARIDE; LONGISTYLIN A; LONGISTYLIN A 2 CARBOXYLIC ACID; LONGISTYLIN C; PINOSTROBIN; PINOSTROBIN CHALCONE; PINOSYLVIN MONOMETHYL ETHER; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA INHIBITOR; UNCLASSIFIED DRUG; COUMARIN DERIVATIVE; CYTOKINE; FLAVANONE DERIVATIVE; NONSTEROID ANTIINFLAMMATORY AGENT; PLANT EXTRACT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; DRUG ISOLATION; FEMALE; IC 50; IN VITRO STUDY; IN VIVO STUDY; MACROPHAGE; NONHUMAN; PIGEONPEA; PLANT LEAF; PRIORITY JOURNAL; RAT; TREATMENT RESPONSE; ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD; CAJANUS; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; IC50; INFLAMMATION; ISOLATION AND PURIFICATION; METABOLISM; MOUSE; SPRAGUE DAWLEY RAT;

CAJANUS; CAJANUS CAJAN; RATTUS;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CAJANUS; CELL LINE; COUMARINS; CYTOKINES; FEMALE; FLAVANONES; INFLAMMATION; INHIBITORY CONCENTRATION 50; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MICE; MOLECULAR STRUCTURE; PLANT EXTRACTS; PLANT LEAVES; RATS, SPRAGUE-DAWLEY; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84901596220     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2014.02.011     Document Type: Article

References (29)

1. S.I. Abdelwahab, S. Mohan, M.A. Abdulla, M.A. Sukari, A.B. Abdul, M.M.E. Taha, S. Syam, S. Ahmad, and K.H. Lee The methanolic extract of Boesenbergia rotunda (L.) Mansf. and its major compound pinostrobin induces anti-ulcerogenic property in vivo: possible involvement of indirect antioxidant action Journal of Ethnopharmacology 137 2011 963 970
2. A.A. Aiyeloja, and O.A. Bello Ethanobotanical potential of common herbs in Nigeria: a case study of Enugu state Educational Research Review 1 2006 16 22
3. S.J. An, H.O. Pae, G.S. Oh, B.M. Choi, S. Jeong, S.I. Jang, H. Oh, T.O. Kwon, C.E. Song, and H.T. Chung Inhibition of TNF-α, IL-1β, and IL-6 productions and NF-κB activation in lipopolysaccharide-activated RAW 264.7 macrophages by catalposide, an iridoid glycoside isolated from Catalpa ovata G. Don (Bignoniaceae) International Immunopharmacology 2 2002 1173 1181
4. J.S. Ashidi, P.J. Houghton, P.J. Hylands, and T. Efferth Ethnobotanical survey and cytotoxicity testing of plants of South-western Nigeria used to treat cancer, with isolation of cytotoxic constituents from Cajanus cajan Millsp. Leaves Journal of Ethnopharmacology 128 2010 501 512
5. M. Comalada, I. Ballester, E. Bailon, S. Sierra, J. Xaus, J. Galvez, F.S. Medina, and A. Zarzuelo Inhibition of pro-inflammatory markers in primary bone marrow-derived mouse macrophages by naturally occurring flavonoids: analysis of the structure-activity relationship Biochemical Pharmacology 72 2006 1010 1021
6. C.J. Cooksey, J.S. Dahiya, P.J. Garratt, and R.N. Strange Two novel stilbene-2-carboxylic acid phytoalexins from Cajanus cajan Phytochemistry 21 1980 2935 2938
7. W.J. Crins, and B.A. Bohm Flavonoid aglycones of Holocarpha obconica Phytochemistry 26 1987 2128 2129
8. G. Duker-Eshun, J.W. Jaroszewski, W.A. Asomaning, F. Oppong-Boachie, and S. Brøgger Christensen Antiplasmodial constituents of Cajanus cajan Phytotherapy Research 18 2004 128 130
9. E. Fernández-Martínez, M.S. Morales-Ríos, V. Pérez-Álvarez, and P. Muriel Immunomodulatory effects of thalidomide analogs on LPS-induced plasma and hepatic cytokines in the rat Biochemical Pharmacology 68 2004 1321 1329
10. P.F. Good, A. Hsu, P. Werner, D.P. Perl, and C.W. Olanow Protein nitration in Parkinson's disease Journal of Neuropathology & Experimental Neurology 57 1998 338 342
11. Y.C. Hseu, F.Y. Wu, J.J. Wu, J.Y. Chen, W.H. Chang, F.J. Lu, Y.C. Lai, and H.L. Yang Anti-inflammatory potential of Antrodia camphorate through inhibition of iNOS, COX-2 and cytokines via the NF-κB pathway International Immunopharmacology 5 2005 1914 1925
12. T. Inoue, Y. Hamada, K. Takeshita, K. Fukushima, and M. Higaki KE-298 and its active metabolite KE-758 suppress nitric oxide production by murine macrophage cells and peritoneal cells from rats with adjuvant induced arthritis The Journal of Rheumatology 28 2001 1229 1237
13. I. Jayaraman, A. Ghanim, and H.A. Khan A new prenylated flavanone [7-methylglabranin] from Tephrosia villosa Phytochemistry 19 1980 1267 1268
14. S.R. Kang, D.Y. Han, K.I. Park, H.S. Park, Y.B. Cho, H.J. Lee, W.S. Lee, C.H. Ryu, Y.L. Ha, D.H. Lee, J.A. Kim, and G.S. Kim Suppressive effect on lipopolysaccharide-induced proinflammatory mediators by Citrus aurantium L. in macrophage RAW 264.7 Cells via NF-κB signal pathway Evidence Based Complementary and Alternative Medicine 2011 2011 1 12
15. K.R. Kirtikar, and B.D. Basu 2nd ed. Indian Medicinal Plants vol. 2 1991 Periodical Expert Book Agency Delhi 1133 1134
16. Y. Kong, Y.J. Fu, Y.G. Zu, F.R. Chang, Y.H. Chen, X.L. Liu, J. Stelten, and H.M. Schiebel Cajanuslactone, a new coumarin with anti-bacterial activity from pigeon pea [Cajanus cajan (L.) Millsp.] leaves Food Chemistry 121 2010 1150 1155
17. Y.S. Lai, W.H. Hsu, J.J. Huang, and S.C. Wu Antioxidant and anti-inflammatory effects of pigeon pea (Cajanus cajan L.) extracts on hydrogen peroxide- and lipopolysaccharide-treated RAW 264.7 macrophages Food & Function 3 2012 1294 1301
18. Q.F. Luo, L. Sun, J.Y. Si, and D.H. Chen Hypocholesterolemic effect of stilbenes containing extract-fraction from Cajanus cajan L. on diet-induced hypercholesterolemia in mice Phytomedicine 15 2008 932 939
19. M. Luo, X. Liu, Y. Zu, Y. Fu, S. Zhang, L. Yao, and T. Efferth Cajanol, a novel anticancer agent from Pigeonpea [Cajanus cajan (L.) Millsp.] roots, induces apoptosis in human breast cancer cells through a ROS-mediated mitochondrial pathway Chemico-Biological Interactions 188 2010 151 160
20. H. Matsuda, S. Tewtrakul, T. Morikawa, and M. Yoshikawa Anti-allergic activity of stilbenes from Korean rhubarb (Rheum undulatum L.): structure requirements for inhibition of antigen-induced degranulation and their effects on the release of TNF-α and IL-4 in RBL-2H3 cells Bioorganic & Medicinal Chemistry 12 2004 4871 4876
21. X.L. Meng, J.Y. Yang, G.L. Chen, L.J. Zhang, L.H. Wang, J. Li, J.M. Wang, and C.F. Wu RV09, a novel resveratrol analogue, inhibits NO and TNF-α production by LPS-activated microglia International Immunopharmacology 8 2008 1074 1082
22. K.S. Ngo, and G.D. Brown Stilbenes, monoterpenes, diarylheptanoids, labdanes and chalcones from Alpinia katsumadai Phytochemistry 47 1998 1117 1123
23. M.A. Palladino, F.R. Bahjat, E.A. Theodorakis, and L.L. Moldawer Anti-TNF-alpha therapies: the next generation Nature Reviews Drug Discovery 2 2003 736 746
24. A.T. Paul, V.M. Gohil, and K.K. Bhutani Modulating TNF-α signaling with natural products Drug Discovery Today 11 2006 725 732
25. A.P. Rauter, A. Martins, C. Borges, J. Ferreira, J. Justino, M.R. Bronze, A.V. Coelho, Y.H. Choi, and R. Verpoorte Liquid chromatography-diode array detection-electrospray ionisation mass spectrometry/nuclear magnetic resonance analyses of the anti-hyperglycemic flavonoid extract of Genista tenera: structure elucidation of a flavonoid-C-glycoside Journal of Chromatography A 1089 2005 59 64
26. K. Shanmugan, L. Holmquist, M. Steele, G. Stuchbury, K. Berbaum, O. Schulz, O. Benavente-Garcia, J. Castillo, J. Burnell, V. Garcia Rivas, G. Dobson, and G. Munch Plant derived polyphenols attenuate lipopolysaccharide- induced nitric oxide and tumour necrosis factor production in murine microglia and macrophages Molecular Nutrition & Food Research 52 2008 427 438
27. N. Wu, K. Fu, Y.J. Fu, Y.G. Zu, F.R. Chang, Y.H. Chen, X.L. Liu, Y. Kong, W. Liu, and C.B. Gu Antioxidant activities of extracts and main components of pigeonpea [Cajanus cajan (L.) Millsp.] leaves Molecules 14 2009 1032 1043
28. J.J. Yoon, Y.J. Lee, J.S. Kim, D.G. Kang, and H.S. Lee Protective role of betulinic acid on TNF-α-induced cell adhesion molecules in vascular endothelial cells Biochemical and Biophysical Research Communications 391 2010 96 101
29. Y. Zu, Y. Fu, W. Liu, C. Hou, and Y. Kong Simultaneous determination of four flavonoids in pigeonpea [Cajanus cajan (L.) Millsp.] leaves using RP-LC-DAD Chromatographia 63 2006 499 505