Cavin-1 is essential for the tumor-promoting effect of caveolin-1 and enhances its prognostic potency in pancreatic cancer

Oncogene

Volumn 33, Issue 21, 2014, Pages 2728-2736

  Liu, L ^a,b   Xu, H X ^a,b   Wang, W Q ^a,b   Wu, C T ^a,b   Chen, T ^a,b   Qin, Y ^a,b   Liu, C ^a,b   Xu, J ^a,b   Long, J ^a,b   Zhang, B ^a,b   Xu, Y F ^a,b   Ni, Q X ^a,b   Li, M ^a,b,c   Yu, X J ^a,b  

^a FUDAN UNIVERSITY   (China)

^b FUDAN UNIVERSITY SHANGHAI CANCER CENTER   (China)

^c UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

caveolin 1; Cavin 1; metastatic potential; pancreatic cancer; prognostic potency

Indexed keywords

CAVEOLIN 1; CAVIN 1; STRUCTURAL PROTEIN; UNCLASSIFIED DRUG;

AGGRESSIVENESS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL; CANCER GROWTH; CANCER PATIENT; CANCER SURVIVAL; CANCER TISSUE; COHORT ANALYSIS; FOLLOW UP; HUMAN; HUMAN CELL; INTERNALIZATION; MALE; METASTASIS POTENTIAL; MOUSE; NONHUMAN; PANCREAS CANCER; PANCREATIC CANCER CELL LINE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN INTERACTION; TISSUE MICROARRAY;

ANIMALS; CAVEOLIN 1; CELL LINE, TUMOR; CELL MEMBRANE; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; HUMANS; KAPLAN-MEIER ESTIMATE; LUNG NEOPLASMS; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; MIDDLE AGED; NEOPLASM TRANSPLANTATION; PANCREATIC NEOPLASMS; PHOSPHATIDYLINOSITOL 3-KINASES; PROGNOSIS; PROTEIN TRANSPORT; RNA-BINDING PROTEINS;

EID: 84901505394     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2013.223     Document Type: Article

References (37)

1. Goetz JG La joie P Wiseman SM Nabi IR. Caveolin-1 in tumor progression: the good the bad and the ugly. Cancer Metastasis Rev 2008; 27: 715-735.
2. Hansen CG Nichols BJ. Exploring the caves: cavins caveolins and caveolae. Trends Cell Biol 2010; 20: 177-186.
3. Wiechen K Diatchenko L Agoulnik A Scharff KM Schober H Arlt K et al. Caveolin-1 is down-regulated in human ovarian carcinoma and acts as a candidate tumor suppressor gene. Am J Pathol 2001; 159: 1635-1643. (Pubitemid 33062506)
4. Bender FC Reymond MA Bron C Quest AF. Caveolin-1 levels are down-regulated in human colon tumors and ectopic expression of caveolin-1 in colon carcinoma cell lines reduces cell tumorigeni city. Cancer Res 2000; 60: 5870-5878.
5. Chiu WT Lee HT Huang FJ Aldape KD Yao J Steeg PS et al. Caveolin-1 upregulation mediates suppression of primary breast tumor growth and br ain metastases by stat3 inhibition. Cancer Res 2011; 71: 4932-4943.
6. Wiechen K Sers C Agoulnik A Arlt K Dietel M Schlag PM et al. Down-regulation of caveolin-1 a candidate tum or suppressor gene in sarcomas. Am J Pathol 2001; 158: 833-839. (Pubitemid 32221776)
7. Fong A Garcia E Gwynn L Lisanti MP Fazzari MJ Li M. Expression of caveolin-1 and caveolin-2 in urothelial carcinoma of the urinary bladder correlates with tumor grade and squamous differentiation. Am J Clin Pathol 2003; 120: 93-100. (Pubitemid 37046375)
8. Kato K Hida Y Miyamoto M Hashida H Shinohara T Itoh T et al. Overexpression of caveolin-1 in esophageal squamous cell carcinoma correlates with lymph node metastasis and pathologic stage. Cancer 2002; 94: 929-933. (Pubitemid 34150846)
9. Li L Yang G Ebara S Satoh T Nasu Y Timme TL et al. Caveolin-1 mediates testosterone-stimulated survival/clonal growth and promotes metastatic activities in prostate cancer cells. Cancer Res 2001; 61: 4386-4392. (Pubitemid 32685764)
10. Ito Y Yoshida H Nakano K Kobayashi K Yokozawa T Hirai K et al. Caveolin-1 overexpression is an early event in the progression of papillary carcinoma of the thyroid. Br J Cancer 2002; 86: 912-916. (Pubitemid 34271027)
11. Murakami S Miyamoto M Hida Y Cho Y Fukunaga A Oshikiri T et al. Caveolin-1 overexpression is a favorable prognostic factor for patients with extrahepatic bile duct carcinoma. Br J Cancer 2003; 88: 1234-1238. (Pubitemid 36606339)
12. Karam JA Lotan Y Roehrborn CG Ashfaq R Karakiewicz PI Shariat SF. Caveolin-1 overexpression is associated with aggressive prostate cancer recurrence. Prostate 2007; 67: 614-622. (Pubitemid 46685281)
13. Ho CC Kuo SH Huang PH Huang HY Yang CH Yang PC. Caveolin-1 expression is significantly associated with drug resistance and poor prognosis in advanced non-small cell lung cancer patients treat ed with gemcitabinebased chemotherapy. Lung Cancer 2008; 59: 105-110.
14. Burgermeister E Xing X Rocken C Juhasz M Chen J Hiber M et al. Differential expression and function of ca veolin-1 in human gastric cancer progression. Cancer Res 2007; 67: 8519-8526. (Pubitemid 47437426)
15. Terris B Blaveri E Crnogorac-Jurcevic T Jones M Missiaglia E Ruszniewski P et al. Characterizatio n of gene expression profiles in intraductal papillary-mucinous tumors of the pancreas. Am J Pathol 2002; 160: 1745-1754. (Pubitemid 34525654)
16. Chen ST Lin SY Yeh KT Kuo SJ Chan WL Chu YP et al. Mu tational epigenetic and expressional analyses of caveolin-1 gene in breast cancers. Int J Mol Med 2004; 14: 577-582.
17. Lin M DiVito MM Mer ajver SD Boyanapalli M van GKL. Regulation of pancreatic cancer cell migration and invasion by RhoC GTPase and caveolin-1. Mol Cancer 2005; 4: 21.
18. Rao X Evans J Chae H Pilrose J Kim S Yan P et al. CpG island shore methylation regulates caveolin-1 expression in breast cancer Oncogene 2013 32 4519-4528.
19. Huang C Qiu Z Wang L Peng Z Jia Z Logsdon CD et al. A novel FoxM1-caveolin signaling pathway promotes pancreatic cancer invasion and metastasis. Cancer Res 2012; 72: 655-665.
20. Nabi IR. Cavin fever: regulating caveolae. Nat Cell Biol 2009; 11: 789-791.
21. Hill MM Bastiani M Luetterforst R Kirkham M Kirkham A Nixon SJ e t al. PTRF-Cavin a conserved cytoplasmic protein required for caveolae formation and function. Cell 2008; 132: 113-124.
22. Hansen CG Bright NA Howard G Nichols BJ. SDPR induces membrane curvature and functions in the formation of caveolae. Nat Cell Biol 2009; 11: 807-814.
23. McMahon KA Zajicek H Li WP Peyton MJ Minna JD Hernandez VJ et al. SRBC/cavin-3 is a cave olin adapter protein that regulates caveolae function. EMBO J 2009; 28: 1001-1015.
24. Bastiani M Liu L Hill MM Jedrychowski MP Nixon SJ Lo HP et al. MURC/Cavin-4 and cavin family members form tissue-specific caveolar complexes. J Cell Biol 2009; 185: 1259-1273.
25. Quest AF Gutierrez-Pajares JL Torres VA. Caveolin-1: an ambiguous partner in cell signalling and cancer. J Cell Mol Med 2008; 12: 1130-1150.
26. Aung CS Hill MM Bastiani M Parton RG Parat MO. PTRF-cavin-1 expression decreases the migration of PC3 prostate cancer cells: role of matrix metalloprotea se 9. Eur J Cell Biol 2011; 90: 136-142.
27. Gamez-Pozo A Sanchez-Navarro I Calvo E Agulló-Ortuno MT López-Vacas R D́az E et al. PTRF/cavin-1 and MIF proteins are identified as non-small cel l lung cancer biomarkers by label-free proteomics. PLoS ONE 2012; 7: e33752.
28. Harris J Werling D Koss M Monaghan P Taylor G Howard CJ. Expression of caveolin by bovine lymphocytes and antigen-presenting cells. Immunology 2002; 105: 190-195. (Pubitemid 34146685)
29. Thomas S Preda-Pais A Casares S Brumeanu TD. Analysis of lipid rafts in T cells. Mol Immunol 2004; 41: 399-409. (Pubitemid 38639892)
30. Joshi B Strugnell SS Goetz JG Kojic LD Cox ME Griffith OL et al. Phosphorylated caveolin-1 regulates Rho/ROCK-dependent focal adhesion dynamics and tumor cell migration and invasion. Cancer Res 2008; 68: 8210-8220.
31. Jansa P Mason SW Hoffmann-Rohrer U Grummt I. Cloning and functional characterization of PTRF a novel protein which induces dissociation of paused ternary transcription complexes. EMBO J 1998; 17: 2855-2864. (Pubitemid 28227132)
32. Hasegawa T Takeuchi A Miyaishi O Xiao H Mao J Isobe K. PTRF (polymerase I and transcript-release factor) is tissue-specific and interacts with the BFCOL1 (binding factor of a type-I collag en promoter) zinc-finger transcription factor which binds to the two mouse type-I collagen gene promoters. Biochem J 2000; 347(Pt 1): 55-59. (Pubitemid 30199040)
33. Shi WD Meng ZQ Chen Z Lin JH Zhou ZH Liu LM . Identification of liver metastasis-related genes in a novel human pancreatic carcinoma cell model by microarray analysis. Cancer Lett 2009; 283: 84-91.
34. Bruns CJ Harbison MT Kuniyasu H Eue I Fidler IJ. In vivo selection and characterization of metastatic variants from human pancreatic adenocarcinoma by using orthotopic implantation in nude mice. Neoplasia 1999; 1: 50-62.
35. Liu L Pilch P F. A critical role of cavin (polymerase I and transcript release factor) in caveolae formation and organization. J Biol Chem 2008; 283: 4314-4322.
36. Liu L Zhu XD Wang WQ Shen Y Qin Y Ren ZG et al. Activation of beta-catenin by hypoxia in hepatocellular carcinoma contributes to enhanced metastatic potential and poor prognosis. Clin Cancer Res 2010; 16: 2740-2750.
37. Liu L Ren ZG Shen Y Zhu XD Zhang W Xiong W et al. Influence of hepatic artery occlusion on tumor growth and metastatic potential in a human orthotopic hepatoma nude mouse model: relevance of epithelial-mesenchymal transition. Cance r Sci 2010; 101: 120-128.