Suppressive effect of microRNA-126 on oral squamous cell carcinoma in vitro

Molecular Medicine Reports

Volumn 10, Issue 1, 2014, Pages 125-130

  Yang, Xiaolun ^a   Wu, Hanjiang ^a   Ling, Tianyou ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Epidermal growth factor like domain 7; microRNA 126; Oral squamous cell carcinoma; Tumor suppressor

Indexed keywords

EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR LIKE DOMAIN PROTEIN 7; FIBROBLAST GROWTH FACTOR 2; MICRORNA 126; UNCLASSIFIED DRUG; VASCULOTROPIN; 3' UNTRANSLATED REGION; ANTISENSE OLIGONUCLEOTIDE; EGFL7 PROTEIN, HUMAN; ENDOTHELIAL CELL GROWTH FACTOR; MICRORNA; MIRN126 MICRORNA, HUMAN; VASCULOTROPIN A;

ANGIOGENESIS; APOPTOSIS; ARTICLE; CELL CYCLE PROGRESSION; CELL INVASION; CELL PROLIFERATION; CLINICAL ARTICLE; COLONY FORMATION; CONTROLLED STUDY; DOWN REGULATION; GENE OVEREXPRESSION; GENE REPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN TISSUE; IN VITRO STUDY; MOUTH SQUAMOUS CELL CARCINOMA; PROTEIN EXPRESSION; TUMOR CELL LINE; UPREGULATION; 3' UNTRANSLATED REGION; ANTAGONISTS AND INHIBITORS; CHEMISTRY; GENETICS; METABOLISM; MOUTH TUMOR; NUCLEOTIDE SEQUENCE; PATHOLOGY; SEQUENCE ALIGNMENT; SQUAMOUS CELL CARCINOMA;

3' UNTRANSLATED REGIONS; BASE SEQUENCE; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CELL PROLIFERATION; ENDOTHELIAL GROWTH FACTORS; FIBROBLAST GROWTH FACTOR 2; HUMANS; MICRORNAS; MOUTH NEOPLASMS; OLIGONUCLEOTIDES, ANTISENSE; SEQUENCE ALIGNMENT; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84901440651     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2014.2171     Document Type: Article

References (22)

1. Lo Muzio L, Santarelli A, Panzarella V, et al: Oral squamous cell carcinoma and biological markers: an update on the molecules mainly involved in oral carcinogenesis. Minerva Stomatol 56: 341-347, 2007.
2. Fan S, Tang QL, Lin YJ, et al: A review of clinical and histological parameters associated with contralateral neck metastases in oral squamous cell carcinoma. Int J Oral Sci 3: 180-191, 2011.
3. Shi Z and Stack MS: Molecules of cell adhesion and extracellular matrix proteolysis in oral squamous cell carcinoma. Histol Histopathol 25: 917-932, 2010.
4. Albini A, Tosetti F, Li VW, Noonan DM and Li WW: Cancer prevention by targeting angiogenesis. Nat Rev Clin Oncol 9: 498-509, 2012.
5. Soncin F, Mattot V, Lionneton F, et al: VE-statin, an endothelial repressor of smooth muscle cell migration. EMBO J 22: 5700-5711, 2003. (Pubitemid 37408810)
6. Parker LH, Schmidt M, Jin SW, et al: The endothelial-cell-derived secreted factor Egfl7 regulates vascular tube formation. Nature 428: 754-758, 2004. (Pubitemid 38514720)
7. Harris TA, Yamakuchi M, Ferlito M, Mendell JT and Lowenstein CJ: MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1. Proc Natl Acad Sci USA 105: 1516-1521, 2008. (Pubitemid 351346546)
8. Wang S, Aurora AB, Johnson BA, et al: The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. Dev Cell 15: 261-271, 2008.
9. Meister J and Schmidt MH: miR-126 and miR-126*: new players in cancer. ScientificWorldJournal 10: 2090-2100, 2010.
10. Wang X, Tang S, Le SY, et al: Aberrant expression of oncogenic and tumor-suppressive microRNAs in cervical cancer is required for cancer cell growth. PLoS One 3: e2557, 2008.
11. Crawford M, Brawner E, Batte K, et al: MicroRNA-126 inhibits invasion in non-small cell lung carcinoma cell lines. Biochem Biophys Res Commun 373: 607-612, 2008.
12. Ladeiro Y, Couchy G, Balabaud C, et al: MicroRNA profiling in hepatocellular tumors is associated with clinical features and oncogene/tumor suppressor gene mutations. Hepatology 47: 1955-1963, 2008. (Pubitemid 351952843)
13. Li Z, Lu J, Sun M, et al: Distinct microRNA expression profiles in acute myeloid leukemia with common translocations. Proc Natl Acad Sci USA 105: 15535-15540, 2008.
14. Saito Y, Friedman JM, Chihara Y, Egger G, Chuang JC and Liang G: Epigenetic therapy upregulates the tumor suppressor microRNA-126 and its host gene EGFL7 in human cancer cells. Biochem Biophys Res Commun 379: 726-731, 2009.
15. Musiyenko A, Bitko V and Barik S: Ectopic expression of miR-126*, an intronic product of the vascular endothelial EGF-like 7 gene, regulates prostein translation and invasiveness of prostate cancer LNCaP cells. J Mol Med (Berl) 86: 313-322, 2008.
16. Feng R, Chen X, Yu Y, et al: miR-126 functions as a tumour suppressor in human gastric cancer. Cancer Lett 298: 50-63, 2010.
17. Bremnes RM, Camps C and Sirera R: Angiogenesis in non-small cell lung cancer: the prognostic impact of neoangiogenesis and the cytokines VEGF and bFGF in tumours and blood. Lung Cancer 51: 143-158, 2006. (Pubitemid 43144358)
18. Guo C, Sah JF, Beard L, Willson JK, Markowitz SD and Guda K: The noncoding RNA, miR-126, suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3-kinase signaling and is frequently lost in colon cancers. Genes Chromosomes Cancer 47: 939-946, 2008.
19. Liu B, Peng XC, Zheng XL, Wang J and Qin YW: MiR-126 restoration down-regulate VEGF and inhibit the growth of lung cancer cell lines in vitro and in vivo. Lung Cancer 66: 169-175, 2009.
20. Li X, Shen Y, Ichikawa H, Antes T and Goldberg GS: Regulation of miRNA expression by Src and contact normalization: effects on nonanchored cell growth and migration. Oncogene 28: 4272-4283, 2009.
21. Birge RB, Kalodimos C, Inagaki F and Tanaka S: Crk and CrkL adaptor proteins: networks for physiological and pathological signaling. Cell Commun Signal 7: 13, 2009.
22. Fish JE, Santoro MM, Morton SU, et al: miR-126 regulates angiogenic signaling and vascular integrity. Dev Cell 15: 272-284, 2008.