Herpes simplex virus-2 transmission probability estimates based on quantity of viral shedding

Journal of the Royal Society Interface

Volumn 11, Issue 95, 2014, Pages

  Schiffer, Joshua T ^a,b   Mayer, Bryan T ^b   Fong, Youyi ^a,b   Swan, David A ^b   Wald, Anna ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b Fred Hutchinson Cancer Research Center   (United States)

Author keywords

Mathematical model; Transmission; Virology

Indexed keywords

MATHEMATICAL MODELS; TRANSMISSIONS;

CLINICAL DETECTION; CLINICAL INTERVENTIONS; HERPES SIMPLEX; HERPES SIMPLEX VIRUS; PROBABILITY ESTIMATE; TRANSMISSION PROBABILITIES; VIRAL PARTICLES; VIROLOGY;

VIRUSES;

VIRUS DNA;

ARTICLE; GENITAL SYSTEM; HERPES SIMPLEX; HERPES SIMPLEX VIRUS 2; HUMAN; KINETICS; MATHEMATICAL MODEL; NONHUMAN; SEXUAL BEHAVIOR; SEXUAL TRANSMISSION; VIRUS LOAD; VIRUS PARTICLE; VIRUS SHEDDING; VIRUS TRANSMISSION; BIOLOGICAL MODEL; FEMALE; GENITAL HERPES; MALE; TRANSMISSION;

FEMALE; HERPES GENITALIS; HERPESVIRUS 2, HUMAN; HUMANS; MALE; MODELS, BIOLOGICAL; VIRUS SHEDDING;

EID: 84901436433     PISSN: 17425689     EISSN: 17425662     Source Type: Journal    
DOI: 10.1098/rsif.2014.0160     Document Type: Article

References (37)

1. Schiffer JT, Wald A, Selke S, Corey L, Magaret A. 2011 The kinetics of mucosal herpes simplex virus-2 infection in humans: evidence for rapid viral-host interactions. J. Infect. Dis. 204, 554-561. (doi:10.1093/infdis/ jir314)
2. Mark KE, Wald A, Magaret AS, Selke S, Olin L, Huang ML, Corey L. 2008 Rapidly cleared episodes of herpes simplex virus reactivation in immunocompetent adults. J. Infect. Dis. 198, 1141-1149. (doi:10.1086/591913)
3. Wald A, Corey L, Cone R, Hobson A, Davis G, Zeh J. 1997 Frequent genital herpes simplex virus 2 shedding in immunocompetent women. Effect of acyclovir treatment. J. Clin. Invest. 99, 1092-1097. (doi:10.1172/JCI119237)
4. Wald A, Zeh J, Selke S, Warren T, Ashley R, Corey L. 2002 Genital shedding of herpes simplex virus among men. J. Infect. Dis. 186(Suppl. 1), S34-S39. (doi:10.1086/342969)
5. Wald A, Zeh J, Selke S, Warren T, Ryncarz A, Ashley R, Krieger JN, Corey L. 2000 Reactivation of genital herpes simplex virus type 2 infection in asymptomatic seropositive persons. N. Engl. J. Med. 342, 844-850. (doi:10.1056/NEJM200003233421203)
6. Tronstein E, Johnston C, Huang ML, Selke S, Magaret A, Warren T, Corey L, Wald A. 2011 Genital shedding of herpes simplex virus among symptomatic and asymptomatic persons with HSV-2 infection. JAMA 305, 1441-1449. (doi:10.1001/jama.2011.420)
7. Wald A, Krantz E, Selke S, Lairson E, Morrow R, Zeh J. 2006 Knowledge of partners' genital herpes protects against herpes simplex virus type 2 acquisition. J. Infect. Dis. 194, 42-52. (doi:10.1086/504717)
8. Mertz GJ et al. 1988 Transmission of genital herpes in couples with one symptomatic and one asymptomatic partner: a prospective study. J. Infect. Dis. 157, 1169-1177. (doi:10.1093/infdis/157.6.1169)
9. Mertz GJ, Schmidt O, Jourden JL, Guinan ME, Remington ML, Fahnlander A, Winter C, Holmes KK, Corey L. 1985 Frequency of acquisition of first-episode genital infection with herpes simplex virus from symptomatic and asymptomatic source contacts. Sex Transm. Dis. 12, 33-39. (doi:10.1097/00007435-198501000- 00007)
10. Weiss H. 2004 Epidemiology of herpes simplex virus type 2 infection in the developing world. Herpes 11(Suppl. 1), 24A-35A. (Pubitemid 38529332)
11. Renzi C et al. 2003 Herpes simplex virus type 2 infection as a risk factor for human immunodeficiency virus acquisition in men who have sex with men. J. Infect. Dis. 187, 19-25. (doi:10.1086/345867)
12. Parr MB, Kepple L, McDermott MR, Drew MD, Bozzola JJ, Parr EL. 1994 A mouse model for studies of mucosal immunity to vaginal infection by herpes simplex virus type 2. Lab Invest. 70, 369-380. (Pubitemid 24116531)
13. Corey L et al. 2004 Once-daily valacyclovir to reduce the risk of transmission of genital herpes. N. Engl. J. Med. 350, 11-20. (doi:10.1056/NEJMoa035144)
14. Johnston C et al. 2012 Standard-dose and high-dose daily antiviral therapy for short episodes of genital HSV-2 reactivation: three randomised, open-label, cross-over trials. Lancet 379, 641-647. (doi:10.1016/s0140-6736(11) 61750-9)
15. Quinn T, Wawer M, Sewankambo N, Serwadda D, Li C, Wabwire-Mangen F, Meehan MO, Lutalo T, Gray RH. 2000 Viral load and heterosexual transmission of human immunodeficiency virus type 1. Rakai Project Study Group. N. Engl. J. Med. 342, 921-929. (doi:10.1056/NEJM200003303421303)
16. Baeten JM et al. 2011 Genital HIV-1 RNA predicts risk of heterosexual HIV-1 transmission. Sci. Transl. Med. 3, 77ra29. (doi:10.1126/scitranslmed. 3001888)
17. Cohen MS et al. 2011 Prevention of HIV-1 infection with early antiretroviral therapy. N. Engl. J. Med. 365, 493-505. (doi:10.1056/ NEJMoa1105243)
18. Schiffer JT et al. 2013 Rapid localized spread and immunologic containment define herpes simplex virus-2 reactivation in the human genital tract. Elife 2, e00288. (doi:10.7554/eLife.00288)
19. Schiffer JT, Abu-Raddad L, Mark KE, Zhu J, Selke S, Magaret A, Wald A, Corey L. 2009 Frequent release of low amounts of herpes simplex virus from neurons: results of a mathematical model. Sci. Transl. Med. 1, 7ra16.
20. Wald A, Langenberg A, Link K, Izu A, Ashley R, Warren T, Tyring S, Douglas Jr JM, Corey L. 2001 Effect of condoms on reducing the transmission of herpes simplex virus type 2 from men to women. JAMA 285, 3100-3106. (doi:10.1001/jama.285.24.3100)
21. Wald A et al. 2005 The relationship between condom use and herpes simplex virus acquisition. Ann. Intern. Med. 143, 707-713. (doi:10.7326/0003-4819-143- 10-200511150-00007)
22. Schiffer JT, Abu-Raddad L, Mark KE, Zhu J, Selke S, Koelle DM, Wald A, Corey L. 2010 Mucosal host immune response predicts the severity and duration of herpes simplex virus-2 genital tract shedding episodes. Proc. Natl Acad. Sci. USA 107, 18 973-18 978. (doi:10.1073/pnas.1006614107)
23. Schiffer JT, Swan DA, Corey L, Wald A. 2013 Rapid viral expansion and short drug half-life explain the incomplete effectiveness of current herpes simplex virus 2-directed antiviral agents. Antimicrob. Agents Chemother. 57, 5820-5829. (doi:10.1128/AAC.01114-13)
24. Mertz GJ, Benedetti J, Ashley R, Selke SA, Corey L. 1992 Risk factors for the sexual transmission of genital herpes. Ann. Intern. Med. 116, 197-202. (doi:10.7326/0003-4819-116-3-197)
25. Schiffer JT, Magaret A, Selke S, Corey L, Wald A. 2011 Detailed analysis of mucosal herpes simplex virus-2 replication kinetics with and without antiviral therapy. J. Antimicrob. Chemother. 66, 2593-2600. (doi:10.1093/jac/ dkr346)
26. Straus SE et al. 1994 Placebo-controlled trial of vaccination with recombinant glycoprotein D of herpes simplex virus type 2 for immunotherapy of genital herpes. Lancet 343, 1460-1463. (doi:10.1016/S0140-6736(94)92581-X)
27. Lingappa JR et al. 2010 Estimating the impact of plasma HIV-1 RNA reductions on heterosexual HIV-1 transmission risk. PLoS ONE 5, e12598. (doi:10.1371/journal.pone.0012598)
28. Tata S, Johnston C, Huang ML, Selke S, Magaret A, Corey L, Wald A. 2010 Overlapping reactivations of herpes simplex virus type 2 in the genital and perianal mucosa. J. Infect. Dis. 201, 499-504. (doi:10.1086/650302)
29. Krone MR, Wald A, Tabet SR, Paradise M, Corey L, Celum CL. 2000 Herpes simplex virus type 2 shedding in human immunodeficiency virusnegative men who have sex with men: frequency, patterns, and risk factors. Clin. Infect. Dis. 30, 261-267. (doi:10.1086/313647)
30. Freeman E, Weiss H, Glynn J, Cross P, Whitworth J, Hayes R. 2006 Herpes simplex virus 2 infection increases HIV acquisition in men and women: systematic review and meta-analysis of longitudinal studies. AIDS 20, 73-83. (doi:10.1097/01.aids.0000198081.09337.a7)
31. Wald A, Link K. 2002 Risk of human immunodeficiency virus infection in herpes simplex virus type 2-seropositive persons: a meta-analysis. J. Infect. Dis. 185, 45-52. (doi:10.1086/338231)
32. Schiffer JT. 2013 Mucosal HSV-2 specific CD8+ Tcells represent containment of prior viral shedding rather than a correlate of future protection. Front. Immunol. 4, 209. (doi:10.3389/fimmu.2013.00209)
33. Blank H, Haines HG. 1973 Experimental human reinfection with herpes simplex virus. J. Invest. Dermatol. 61, 223-225. (doi:10.1111/1523-1747. ep12676442)
34. Corey L, Adams HG, Brown ZA, Holmes KK. 1983 Genital herpes simplex virus infections: clinical manifestations, course, and complications. Ann. Intern. Med. 98, 958-972. (doi:10.7326/0003-4819-98-6-958)
35. Zhu J, Koelle D, Cao J, Vazquez J, Huang M, Hladik F, Wald A, Corey L. 2007 Virus-specific CD8+ T cells accumulate near sensory nerve endings in genital skin during subclinical HSV-2 reactivation. J. Exp. Med. 204, 595-603. (doi:10.1084/jem.20061792)
36. Zhu J et al. 2009 Persistence of HIV-1 receptor-positive cells after HSV-2 reactivation is a potential mechanism for increased HIV-1 acquisition. Nat. Med. 15, 886-892. (doi:10.1038/nm.2006)
37. Mayer BT, Koopman JS, Ionides EL, Pujol JM, Eisenberg JN. 2011 A dynamic dose-response model to account for exposure patterns in risk assessment: a case study in inhalation anthrax. J. R. Soc. Interface 8, 506-517. (doi:10.1098/rsif.2010.0491)