Low-dose 6-bromoindirubin-3′-oxime induces partial dedifferentiation of endothelial cells to promote increased neovascularization

Stem Cells

Volumn 32, Issue 6, 2014, Pages 1538-1552

  Kohler, Erin E ^a   Baruah, Jugajyoti ^a   Urao, Norifumi ^a   Ushio Fukai, Masuko ^a   Fukai, Tohru ^a   Chatterjee, Ishita ^a   Wary, Kishore K ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

6 Bromoindirubin 3 oxime; Dedifferentiation; Endothelial cells; Hind limb ischemia; Neovascularization

Indexed keywords

6 BROMOINDIRUBIN 3' OXIME; ALPHA ACTIN; BETA CATENIN; BROXURIDINE; GLYCOGEN SYNTHASE KINASE 3 INHIBITOR; NOTCH1 RECEPTOR; TRANSCRIPTION FACTOR NANOG; UNCLASSIFIED DRUG; VASCULAR ENDOTHELIAL CADHERIN; VASCULOTROPIN; 6-BROMOINDIRUBIN-3'-OXIME; ANGIOGENIC FACTOR; BRACHYURY PROTEIN; FETOPROTEIN; HOMEODOMAIN PROTEIN; INDOLE DERIVATIVE; NANOG PROTEIN, HUMAN; OXIME; PROTEIN BINDING; T BOX TRANSCRIPTION FACTOR; VASCULOTROPIN A;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASYMMETRIC CELL DIVISION; CELL DEDIFFERENTIATION; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; ANIMAL; CELL AGGREGATION; CELL DIVISION; CELL MOTION; CELL NUCLEUS; CYTOLOGY; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; GENETICS; HINDLIMB; ISCHEMIA; METABOLISM; PATHOLOGY; PHENOTYPE; PLURIPOTENT STEM CELL; PROTEIN STABILITY; UMBILICAL VEIN ENDOTHELIAL CELL; VASCULARIZATION;

ANGIOGENESIS INDUCING AGENTS; ANIMALS; BETA CATENIN; CELL AGGREGATION; CELL DEDIFFERENTIATION; CELL DIVISION; CELL MOVEMENT; CELL NUCLEUS; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; FETAL PROTEINS; HINDLIMB; HOMEODOMAIN PROTEINS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INDOLES; ISCHEMIA; MICE; NEOVASCULARIZATION, PHYSIOLOGIC; OXIMES; PHENOTYPE; PLURIPOTENT STEM CELLS; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTEIN STABILITY; T-BOX DOMAIN PROTEINS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84901419136     PISSN: 10665099     EISSN: 15494918     Source Type: Journal    
DOI: 10.1002/stem.1658     Document Type: Article

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