Validating fragment-based drug discovery for biological RNAs: Lead fragments bind and remodel the TPP riboswitch specifically

Chemistry and Biology

Volumn 21, Issue 5, 2014, Pages 591-595

  Warner, Katherine Deigan ^a,b   Homan, Philip ^c   Weeks, Kevin M ^c   Smith, Alison G ^b   Abell, Chris ^b   Ferré D'Amaré, Adrian R ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c University of North Carolina at Chapel Hill   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COCARBOXYLASE; THIAMINE; LIGAND; RIBOSWITCH; RNA;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; DRUG SCREENING; INTERACTIONS WITH RNA; PRIORITY JOURNAL; PROTEIN RNA BINDING; RIBOSWITCH; RNA CONFORMATION; RNA FOLDING; X RAY CRYSTALLOGRAPHY; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DEVELOPMENT; ENZYME SPECIFICITY; GENETICS; METABOLISM; REPRODUCIBILITY;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DRUG DISCOVERY; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; REPRODUCIBILITY OF RESULTS; RIBOSWITCH; RNA; SUBSTRATE SPECIFICITY; THIAMINE PYROPHOSPHATE;

EID: 84901406647     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2014.03.007     Document Type: Article

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