Glyoxalase I reduces glycative and oxidative stress and prevents age-related endothelial dysfunction through modulation of endothelial nitric oxide synthase phosphorylation

Aging Cell

Volumn 13, Issue 3, 2014, Pages 519-528

  Jo Watanabe, Airi ^a   Ohse, Takamoto ^a   Nishimatsu, Hiroaki ^b   Takahashi, Masao ^c   Ikeda, Yoichiro ^a   Wada, Takehiko ^a   Shirakawa, Jun ichi ^d   Nagai, Ryoji ^d   Miyata, Toshio ^e   Nagano, Tetsuo ^b   Hirata, Yasunobu ^f   Inagi, Reiko ^a,c   Nangaku, Masaomi ^a  

^a Division of Nephrology   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d TOKAI UNIVERSITY   (Japan)

^e TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^f Graduate School of Pharmaceutical Sciences The University of Tokyo ^*  (Japan)

Author keywords

Advanced glycation end products; Aging; Endothelial dysfunction; Endothelial nitric oxide synthase; Glycation; Glyoxalase I

Indexed keywords

4 HYDROXYNONENAL; 6 N CARBOXYMETHYLLYSINE; 8 HYDROXYDEOXYGUANOSINE; ACETYLCHOLINE; CARBONYL DERIVATIVE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; LACTOYLGLUTATHIONE LYASE; NITRATE; NITRIC OXIDE; NITRITE; NITROPRUSSIDE SODIUM; ADVANCED GLYCATION END PRODUCT; NOS3 PROTEIN, HUMAN;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOAVAILABILITY; BLOOD PRESSURE MEASUREMENT; BLOOD VESSEL REACTIVITY; CELL STRESS; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GLYCATION; GLYCATIVE STRESS; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; VASODILATATION; WESTERN BLOTTING; AGE; ANIMAL; CARDIOVASCULAR DISEASE; GENETIC TRANSFECTION; GENETICS; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; TRANSGENIC RAT; VASCULAR ENDOTHELIUM;

RATTUS;

AGE FACTORS; ANIMALS; CARDIOVASCULAR DISEASES; ENDOTHELIUM, VASCULAR; GLYCOSYLATION END PRODUCTS, ADVANCED; HUMANS; NITRIC OXIDE SYNTHASE TYPE III; OXIDATIVE STRESS; PHOSPHORYLATION; RATS; RATS, TRANSGENIC; TRANSFECTION;

EID: 84901405206     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12204     Document Type: Article

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