Protein kinase CβII-mediated phosphorylation of endothelial nitric oxide synthase threonine 495 mediates the endothelial dysfunction induced by FK506 (Tacrolimus)

Journal of Pharmacology and Experimental Therapeutics

Volumn 337, Issue 3, 2011, Pages 718-723

  Chiasson, Valorie L ^a   Quinn, Matthew A ^a   Young, Kristina J ^a   Mitchell, Brett M ^a  

^a TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; PROTEIN KINASE C BETA; PROTEIN KINASE C BETA2; TACROLIMUS; THREONINE; UNCLASSIFIED DRUG; IMMUNOSUPPRESSIVE AGENT; PROTEIN KINASE C;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA; ARTICLE; BLOOD VESSEL REACTIVITY; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; VASODILATATION; ANIMAL; C57BL MOUSE; CELL CULTURE; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; PHOSPHORYLATION; VASCULAR DISEASE;

ANIMALS; AORTA; CELLS, CULTURED; ENDOTHELIAL CELLS; IMMUNOSUPPRESSIVE AGENTS; MALE; MICE; MICE, INBRED C57BL; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHORYLATION; PROTEIN KINASE C; RATS; TACROLIMUS; THREONINE; VASCULAR DISEASES;

EID: 79956196405     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.110.178095     Document Type: Article

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