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Volumn 51, Issue 2, 2014, Pages 89-97

Direct Oral Anticoagulants-Pharmacology, Drug Interactions, and Side Effects

Author keywords

[No Author keywords available]

Indexed keywords

ANTICOAGULANT AGENT; APIXABAN; BLOOD CLOTTING FACTOR 10A; DABIGATRAN; DRUG METABOLITE; EDOXABAN; HEPARIN DERIVATIVE; LOW MOLECULAR WEIGHT HEPARIN; RIVAROXABAN; THROMBIN;

EID: 84901374763     PISSN: 00371963     EISSN: 15328686     Source Type: Journal    
DOI: 10.1053/j.seminhematol.2014.03.005     Document Type: Article
Times cited : (37)

References (72)
  • 1
    • 49149130353 scopus 로고    scopus 로고
    • Dabigatran etexilate
    • Sanford M., Plosker G.L. Dabigatran etexilate. Drugs 2008, 68:1699-1709.
    • (2008) Drugs , vol.68 , pp. 1699-1709
    • Sanford, M.1    Plosker, G.L.2
  • 2
    • 84878290471 scopus 로고    scopus 로고
    • Betrixaban compared with warfarin in patients with atrial fibrillation: results of a phase 2, randomized, dose-ranging study (Explore-Xa)
    • Connolly S.J., Eikelboom J., Dorian P., et al. Betrixaban compared with warfarin in patients with atrial fibrillation: results of a phase 2, randomized, dose-ranging study (Explore-Xa). Eur Heart J 2013, 34:1498-1505.
    • (2013) Eur Heart J , vol.34 , pp. 1498-1505
    • Connolly, S.J.1    Eikelboom, J.2    Dorian, P.3
  • 3
    • 84878903500 scopus 로고    scopus 로고
    • Apixaban: a review of its use for reducing the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation
    • Keating G.M. Apixaban: a review of its use for reducing the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation. Drugs 2013, 73:825-843.
    • (2013) Drugs , vol.73 , pp. 825-843
    • Keating, G.M.1
  • 4
    • 84878645045 scopus 로고    scopus 로고
    • Managing new oral anticoagulants in the perioperative and intensive care unit setting
    • Levy J.H., Faraoni D., Spring J.L., Douketis J.D., Samama C.M. Managing new oral anticoagulants in the perioperative and intensive care unit setting. Anesthesiology 2013, 118:1466-1474.
    • (2013) Anesthesiology , vol.118 , pp. 1466-1474
    • Levy, J.H.1    Faraoni, D.2    Spring, J.L.3    Douketis, J.D.4    Samama, C.M.5
  • 5
    • 84856600313 scopus 로고    scopus 로고
    • Heparin-induced thrombocytopenia: in vitro studies on the interaction of dabigatran, rivaroxaban, and low-sulfated heparin, with platelet factor 4 and anti-PF4/heparin antibodies
    • Krauel K., Hackbarth C., Furll B., Greinacher A. Heparin-induced thrombocytopenia: in vitro studies on the interaction of dabigatran, rivaroxaban, and low-sulfated heparin, with platelet factor 4 and anti-PF4/heparin antibodies. Blood 2012, 119:1248-1255.
    • (2012) Blood , vol.119 , pp. 1248-1255
    • Krauel, K.1    Hackbarth, C.2    Furll, B.3    Greinacher, A.4
  • 6
    • 34250030035 scopus 로고    scopus 로고
    • Antithrombotic and anticoagulant effects of the direct thrombin inhibitor dabigatran, and its oral prodrug, dabigatran etexilate, in a rabbit model of venous thrombosis
    • Wienen W., Stassen J.M., Priepke H., Ries U.J., Hauel N. Antithrombotic and anticoagulant effects of the direct thrombin inhibitor dabigatran, and its oral prodrug, dabigatran etexilate, in a rabbit model of venous thrombosis. J Thromb Haemost 2007, 5:1237-1242.
    • (2007) J Thromb Haemost , vol.5 , pp. 1237-1242
    • Wienen, W.1    Stassen, J.M.2    Priepke, H.3    Ries, U.J.4    Hauel, N.5
  • 7
    • 0037171819 scopus 로고    scopus 로고
    • Structure-based design of novel potent nonpeptide thrombin inhibitors
    • Hauel N.H., Nar H., Priepke H., Ries U., Stassen J.M., Wienen W. Structure-based design of novel potent nonpeptide thrombin inhibitors. J Med Chem 2002, 45:1757-1766.
    • (2002) J Med Chem , vol.45 , pp. 1757-1766
    • Hauel, N.H.1    Nar, H.2    Priepke, H.3    Ries, U.4    Stassen, J.M.5    Wienen, W.6
  • 8
    • 41949116970 scopus 로고    scopus 로고
    • Clinical pharmacokinetics and pharmacodynamics of the oral direct thrombin inhibitor dabigatran etexilate
    • Stangier J. Clinical pharmacokinetics and pharmacodynamics of the oral direct thrombin inhibitor dabigatran etexilate. Clin Pharmacokinet 2008, 47:285-295.
    • (2008) Clin Pharmacokinet , vol.47 , pp. 285-295
    • Stangier, J.1
  • 9
    • 71849117615 scopus 로고    scopus 로고
    • Dabigatran versus warfarin in the treatment of acute venous thromboembolism
    • Schulman S., Kearon C., Kakkar A.K., et al. Dabigatran versus warfarin in the treatment of acute venous thromboembolism. N Engl J Med 2009, 361:2342-2352.
    • (2009) N Engl J Med , vol.361 , pp. 2342-2352
    • Schulman, S.1    Kearon, C.2    Kakkar, A.K.3
  • 10
    • 70349306707 scopus 로고    scopus 로고
    • Dabigatran versus warfarin in patients with atrial fibrillation
    • Connolly S.J., Ezekowitz M.D., Yusuf S., et al. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med 2009, 361:1139-1151.
    • (2009) N Engl J Med , vol.361 , pp. 1139-1151
    • Connolly, S.J.1    Ezekowitz, M.D.2    Yusuf, S.3
  • 11
    • 34548031359 scopus 로고    scopus 로고
    • The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects
    • Stangier J., Rathgen K., Stahle H., Gansser D., Roth W. The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects. Br J Clin Pharmacol 2007, 64:292-303.
    • (2007) Br J Clin Pharmacol , vol.64 , pp. 292-303
    • Stangier, J.1    Rathgen, K.2    Stahle, H.3    Gansser, D.4    Roth, W.5
  • 12
    • 77949421739 scopus 로고    scopus 로고
    • Influence of renal impairment on the pharmacokinetics and pharmacodynamics of oral dabigatran etexilate: an open-label, parallel-group, single-centre study
    • Stangier J., Rathgen K., Stahle H., Mazur D. Influence of renal impairment on the pharmacokinetics and pharmacodynamics of oral dabigatran etexilate: an open-label, parallel-group, single-centre study. Clin Pharmacokinet 2010, 49:259-268.
    • (2010) Clin Pharmacokinet , vol.49 , pp. 259-268
    • Stangier, J.1    Rathgen, K.2    Stahle, H.3    Mazur, D.4
  • 13
    • 77952167209 scopus 로고    scopus 로고
    • Pharmacology, pharmacokinetics, and pharmacodynamics of dabigatran etexilate, an oral direct thrombin inhibitor
    • Stangier J., Clemens A. Pharmacology, pharmacokinetics, and pharmacodynamics of dabigatran etexilate, an oral direct thrombin inhibitor. Clin Appl Thromb Hemost 2009, 15(Suppl 1):9S-16S.
    • (2009) Clin Appl Thromb Hemost , vol.15 , Issue.SUPPL 1
    • Stangier, J.1    Clemens, A.2
  • 14
    • 17644400166 scopus 로고    scopus 로고
    • Pharmacokinetic profile of the oral direct thrombin inhibitor dabigatran etexilate in healthy volunteers and patients undergoing total hip replacement
    • Stangier J., Eriksson B.I., Dahl O.E., et al. Pharmacokinetic profile of the oral direct thrombin inhibitor dabigatran etexilate in healthy volunteers and patients undergoing total hip replacement. J Clin Pharmacol 2005, 45:555-563.
    • (2005) J Clin Pharmacol , vol.45 , pp. 555-563
    • Stangier, J.1    Eriksson, B.I.2    Dahl, O.E.3
  • 15
    • 77953168824 scopus 로고    scopus 로고
    • Dabigatran etexilate-a novel, reversible, oral direct thrombin inhibitor: interpretation of coagulation assays and reversal of anticoagulant activity
    • van Ryn J., Stangier J., Haertter S., Liesenfeld K.H., Wienen W., Feuring M., Clemens A. Dabigatran etexilate-a novel, reversible, oral direct thrombin inhibitor: interpretation of coagulation assays and reversal of anticoagulant activity. Thromb Haemost 2010, 103:1116-1127.
    • (2010) Thromb Haemost , vol.103 , pp. 1116-1127
    • van Ryn, J.1    Stangier, J.2    Haertter, S.3    Liesenfeld, K.H.4    Wienen, W.5    Feuring, M.6    Clemens, A.7
  • 16
    • 57449094606 scopus 로고    scopus 로고
    • Comparative pharmacodynamics and pharmacokinetics of oral direct thrombin and factor xa inhibitors in development
    • Eriksson B.I., Quinlan D.J., Weitz J.I. Comparative pharmacodynamics and pharmacokinetics of oral direct thrombin and factor xa inhibitors in development. Clin Pharmacokinet 2009, 48:1-22.
    • (2009) Clin Pharmacokinet , vol.48 , pp. 1-22
    • Eriksson, B.I.1    Quinlan, D.J.2    Weitz, J.I.3
  • 17
    • 80055122488 scopus 로고    scopus 로고
    • Population pharmacokinetic analysis of the oral thrombin inhibitor dabigatran etexilate in patients with non-valvular atrial fibrillation from the RE-LY trial
    • Liesenfeld K.H., Lehr T., Dansirikul C., Reilly P.A., Connolly S.J., Ezekowitz M.D., Yusuf S., et al. Population pharmacokinetic analysis of the oral thrombin inhibitor dabigatran etexilate in patients with non-valvular atrial fibrillation from the RE-LY trial. J Thromb Haemost 2011, 9:2168-2175.
    • (2011) J Thromb Haemost , vol.9 , pp. 2168-2175
    • Liesenfeld, K.H.1    Lehr, T.2    Dansirikul, C.3    Reilly, P.A.4    Connolly, S.J.5    Ezekowitz, M.D.6    Yusuf, S.7
  • 18
    • 84856433905 scopus 로고    scopus 로고
    • A combined pharmacometric analysis of dabigatran etexilate in healthy volunteers and patients with atrial fibrillation or undergoing orthopaedic surgery
    • Dansirikul C., Lehr T., Liesenfeld K.H., Haertter S., Staab A. A combined pharmacometric analysis of dabigatran etexilate in healthy volunteers and patients with atrial fibrillation or undergoing orthopaedic surgery. Thromb Haemost 2012, 107:775-785.
    • (2012) Thromb Haemost , vol.107 , pp. 775-785
    • Dansirikul, C.1    Lehr, T.2    Liesenfeld, K.H.3    Haertter, S.4    Staab, A.5
  • 19
    • 57449098437 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of dabigatran etexilate, an oral direct thrombin inhibitor, are not affected by moderate hepatic impairment
    • Stangier J., Stahle H., Rathgen K., Roth W., Shakeri-Nejad K. Pharmacokinetics and pharmacodynamics of dabigatran etexilate, an oral direct thrombin inhibitor, are not affected by moderate hepatic impairment. J Clin Pharmacol 2008, 48:1411-1419.
    • (2008) J Clin Pharmacol , vol.48 , pp. 1411-1419
    • Stangier, J.1    Stahle, H.2    Rathgen, K.3    Roth, W.4    Shakeri-Nejad, K.5
  • 20
    • 37149005153 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of the direct oral thrombin inhibitor dabigatran in healthy elderly subjects
    • Stangier J., Stahle H., Rathgen K., Fuhr R. Pharmacokinetics and pharmacodynamics of the direct oral thrombin inhibitor dabigatran in healthy elderly subjects. Clin Pharmacokinet 2008, 47:47-59.
    • (2008) Clin Pharmacokinet , vol.47 , pp. 47-59
    • Stangier, J.1    Stahle, H.2    Rathgen, K.3    Fuhr, R.4
  • 21
    • 79958077792 scopus 로고    scopus 로고
    • Drug and dietary interactions of warfarin and novel oral anticoagulants: an update
    • Nutescu E., Chuatrisorn I., Hellenbart E. Drug and dietary interactions of warfarin and novel oral anticoagulants: an update. J Thromb Thrombolysis 2011, 31:326-343.
    • (2011) J Thromb Thrombolysis , vol.31 , pp. 326-343
    • Nutescu, E.1    Chuatrisorn, I.2    Hellenbart, E.3
  • 22
    • 84873569160 scopus 로고    scopus 로고
    • Concomitant use of antiplatelet therapy with dabigatran or warfarin in the Randomized Evaluation of Long-Term Anticoagulation Therapy (RE-LY) trial
    • Dans A.L., Connolly S.J., Wallentin L., Yang S., et al. Concomitant use of antiplatelet therapy with dabigatran or warfarin in the Randomized Evaluation of Long-Term Anticoagulation Therapy (RE-LY) trial. Circulation 2013, 127:634-640.
    • (2013) Circulation , vol.127 , pp. 634-640
    • Dans, A.L.1    Connolly, S.J.2    Wallentin, L.3    Yang, S.4
  • 23
    • 84856435683 scopus 로고    scopus 로고
    • Twice daily dosing of dabigatran for stroke prevention in atrial fibrillation: a pharmacokinetic justification
    • Clemens A., Haertter S., Friedman J., Brueckmann M., Stangier J., van Ryn J., Lehr T. Twice daily dosing of dabigatran for stroke prevention in atrial fibrillation: a pharmacokinetic justification. Curr Med Res Opin 2012, 28:195-201.
    • (2012) Curr Med Res Opin , vol.28 , pp. 195-201
    • Clemens, A.1    Haertter, S.2    Friedman, J.3    Brueckmann, M.4    Stangier, J.5    van Ryn, J.6    Lehr, T.7
  • 24
    • 84856593171 scopus 로고    scopus 로고
    • Using the HEMOCLOT direct thrombin inhibitor assay to determine plasma concentrations of dabigatran
    • Stangier J., Feuring M. Using the HEMOCLOT direct thrombin inhibitor assay to determine plasma concentrations of dabigatran. Blood Coagul Fibrinolysis 2012, 23:138-143.
    • (2012) Blood Coagul Fibrinolysis , vol.23 , pp. 138-143
    • Stangier, J.1    Feuring, M.2
  • 25
    • 84859788384 scopus 로고    scopus 로고
    • Dabigatran etexilate for stroke prevention in patients with atrial fibrillation: resolving uncertainties in routine practice
    • Huisman M.V., Lip G.Y., Diener H.C., Brueckmann M., van Ryn J., Clemens A. Dabigatran etexilate for stroke prevention in patients with atrial fibrillation: resolving uncertainties in routine practice. Thromb Haemost 2012, 107.
    • (2012) Thromb Haemost , pp. 107
    • Huisman, M.V.1    Lip, G.Y.2    Diener, H.C.3    Brueckmann, M.4    van Ryn, J.5    Clemens, A.6
  • 27
    • 79952496003 scopus 로고    scopus 로고
    • Rivaroxaban for the prevention of venous thromboembolism after hip or knee arthroplasty. Pooled analysis of four studies
    • Turpie A.G., Lassen M.R., Eriksson B.I., et al. Rivaroxaban for the prevention of venous thromboembolism after hip or knee arthroplasty. Pooled analysis of four studies. Thromb Haemost 2011, 105:444-453.
    • (2011) Thromb Haemost , vol.105 , pp. 444-453
    • Turpie, A.G.1    Lassen, M.R.2    Eriksson, B.I.3
  • 28
    • 80052592404 scopus 로고    scopus 로고
    • Rivaroxaban versus warfarin in nonvalvular atrial fibrillation
    • Patel M.R., Mahaffey K.W., Garg J., et al. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med 2011, 365:883-891.
    • (2011) N Engl J Med , vol.365 , pp. 883-891
    • Patel, M.R.1    Mahaffey, K.W.2    Garg, J.3
  • 30
    • 84859385808 scopus 로고    scopus 로고
    • Oral rivaroxaban for the treatment of symptomatic pulmonary embolism
    • Buller H.R., Prins M.H., Lensin A.W., et al. Oral rivaroxaban for the treatment of symptomatic pulmonary embolism. N Engl J Med 2012, 366:1287-1297.
    • (2012) N Engl J Med , vol.366 , pp. 1287-1297
    • Buller, H.R.1    Prins, M.H.2    Lensin, A.W.3
  • 31
    • 34447317298 scopus 로고    scopus 로고
    • Treatment of proximal deep-vein thrombosis with the oral direct factor Xa inhibitor rivaroxaban (BAY 59-7939): the ODIXa-DVT (Oral Direct Factor Xa Inhibitor BAY 59-7939 in Patients With Acute Symptomatic Deep-Vein Thrombosis) study
    • Agnelli G., Gallus A., Goldhaber S.Z., Haas S., Huisman M.V., Hull R.D., Kakkar A.K., et al. Treatment of proximal deep-vein thrombosis with the oral direct factor Xa inhibitor rivaroxaban (BAY 59-7939): the ODIXa-DVT (Oral Direct Factor Xa Inhibitor BAY 59-7939 in Patients With Acute Symptomatic Deep-Vein Thrombosis) study. Circulation 2007, 116:180-187.
    • (2007) Circulation , vol.116 , pp. 180-187
    • Agnelli, G.1    Gallus, A.2    Goldhaber, S.Z.3    Haas, S.4    Huisman, M.V.5    Hull, R.D.6    Kakkar, A.K.7
  • 32
    • 53849123533 scopus 로고    scopus 로고
    • A dose-ranging study evaluating once-daily oral administration of the factor Xa inhibitor rivaroxaban in the treatment of patients with acute symptomatic deep vein thrombosis: the Einstein-DVT Dose-Ranging Study
    • Buller H.R., Lensing A.W., Prins M.H., Agnelli G., Cohen A., Gallus A.S., Misselwitz F., et al. A dose-ranging study evaluating once-daily oral administration of the factor Xa inhibitor rivaroxaban in the treatment of patients with acute symptomatic deep vein thrombosis: the Einstein-DVT Dose-Ranging Study. Blood 2008, 112:2242-2247.
    • (2008) Blood , vol.112 , pp. 2242-2247
    • Buller, H.R.1    Lensing, A.W.2    Prins, M.H.3    Agnelli, G.4    Cohen, A.5    Gallus, A.S.6    Misselwitz, F.7
  • 33
    • 51349095537 scopus 로고    scopus 로고
    • Population pharmacokinetics and pharmacodynamics of once- and twice-daily rivaroxaban for the prevention of venous thromboembolism in patients undergoing total hip replacement
    • Mueck W., Borris L.C., Dahl O.E., et al. Population pharmacokinetics and pharmacodynamics of once- and twice-daily rivaroxaban for the prevention of venous thromboembolism in patients undergoing total hip replacement. Thromb Haemost 2008, 100:453-461.
    • (2008) Thromb Haemost , vol.100 , pp. 453-461
    • Mueck, W.1    Borris, L.C.2    Dahl, O.E.3
  • 34
    • 80052485992 scopus 로고    scopus 로고
    • Rivaroxaban: population pharmacokinetic analyses in patients treated for acute deep-vein thrombosis and exposure simulations in patients with atrial fibrillation treated for stroke prevention
    • Mueck W., Lensing A.W., Agnelli G., Decousus H., Prandoni P., Misselwitz F. Rivaroxaban: population pharmacokinetic analyses in patients treated for acute deep-vein thrombosis and exposure simulations in patients with atrial fibrillation treated for stroke prevention. Clin Pharmacokinet 2011, 50:675-686.
    • (2011) Clin Pharmacokinet , vol.50 , pp. 675-686
    • Mueck, W.1    Lensing, A.W.2    Agnelli, G.3    Decousus, H.4    Prandoni, P.5    Misselwitz, F.6
  • 35
    • 29144518504 scopus 로고    scopus 로고
    • Safety, pharmacodynamics, and pharmacokinetics of BAY 59-7939--an oral, direct Factor Xa inhibitor-after multiple dosing in healthy male subjects
    • Kubitza D., Becka M., Wensing G., Voith B., Zuehlsdorf M. Safety, pharmacodynamics, and pharmacokinetics of BAY 59-7939--an oral, direct Factor Xa inhibitor-after multiple dosing in healthy male subjects. Eur J Clin Pharmacol 2005, 61:873-880.
    • (2005) Eur J Clin Pharmacol , vol.61 , pp. 873-880
    • Kubitza, D.1    Becka, M.2    Wensing, G.3    Voith, B.4    Zuehlsdorf, M.5
  • 36
    • 33747068794 scopus 로고    scopus 로고
    • Safety, tolerability, pharmacodynamics, and pharmacokinetics of rivaroxaban-an oral, direct factor Xa inhibitor--are not affected by aspirin
    • Kubitza D., Becka M., Mueck W., Zuehlsdorf M. Safety, tolerability, pharmacodynamics, and pharmacokinetics of rivaroxaban-an oral, direct factor Xa inhibitor--are not affected by aspirin. J Clin Pharmacol 2006, 46:981-990.
    • (2006) J Clin Pharmacol , vol.46 , pp. 981-990
    • Kubitza, D.1    Becka, M.2    Mueck, W.3    Zuehlsdorf, M.4
  • 37
    • 25844525489 scopus 로고    scopus 로고
    • Safety, pharmacodynamics, and pharmacokinetics of single doses of BAY 59-7939, an oral, direct factor Xa inhibitor
    • Kubitza D., Becka M., Voith B., Zuehlsdorf M., Wensing G. Safety, pharmacodynamics, and pharmacokinetics of single doses of BAY 59-7939, an oral, direct factor Xa inhibitor. Clin Pharmacol Ther 2005, 78:412-421.
    • (2005) Clin Pharmacol Ther , vol.78 , pp. 412-421
    • Kubitza, D.1    Becka, M.2    Voith, B.3    Zuehlsdorf, M.4    Wensing, G.5
  • 38
    • 34250166525 scopus 로고    scopus 로고
    • Population model of the pharmacokinetics and pharmacodynamics of rivaroxaban-an oral, direct factor Xa inhibitor--in healthy subjects. Int J
    • Mueck W., Becka M., Kubitza D., Voith B., Zuehlsdorf M. Population model of the pharmacokinetics and pharmacodynamics of rivaroxaban-an oral, direct factor Xa inhibitor--in healthy subjects. Int J. Clin Pharmacol Ther 2007, 45:335-344.
    • (2007) Clin Pharmacol Ther , vol.45 , pp. 335-344
    • Mueck, W.1    Becka, M.2    Kubitza, D.3    Voith, B.4    Zuehlsdorf, M.5
  • 39
    • 33645779998 scopus 로고    scopus 로고
    • Effect of food, an antacid, and the H2 antagonist ranitidine on the absorption of BAY 59-7939 (rivaroxaban), an oral, direct factor Xa inhibitor, in healthy subjects
    • Kubitza D., Becka M., Zuehlsdorf M., Mueck W. Effect of food, an antacid, and the H2 antagonist ranitidine on the absorption of BAY 59-7939 (rivaroxaban), an oral, direct factor Xa inhibitor, in healthy subjects. J Clin Pharmacol 2006, 46:549-558.
    • (2006) J Clin Pharmacol , vol.46 , pp. 549-558
    • Kubitza, D.1    Becka, M.2    Zuehlsdorf, M.3    Mueck, W.4
  • 40
    • 35448932027 scopus 로고    scopus 로고
    • Effects of the oral, direct factor xa inhibitor rivaroxaban on platelet-induced thrombin generation and prothrombinase activity
    • Graff J., von Hentig N., Misselwitz F., Kubitza D., Becka M., Breddin H.K., Harder S. Effects of the oral, direct factor xa inhibitor rivaroxaban on platelet-induced thrombin generation and prothrombinase activity. J Clin Pharmacol 2007, 47:1398-1407.
    • (2007) J Clin Pharmacol , vol.47 , pp. 1398-1407
    • Graff, J.1    von Hentig, N.2    Misselwitz, F.3    Kubitza, D.4    Becka, M.5    Breddin, H.K.6    Harder, S.7
  • 41
    • 33846448135 scopus 로고    scopus 로고
    • Body weight has limited influence on the safety, tolerability, pharmacokinetics, or pharmacodynamics of rivaroxaban (BAY 59-7939) in healthy subjects
    • Kubitza D., Becka M., Zuehlsdorf M., Mueck W. Body weight has limited influence on the safety, tolerability, pharmacokinetics, or pharmacodynamics of rivaroxaban (BAY 59-7939) in healthy subjects. J Clin Pharmacol 2007, 47:218-226.
    • (2007) J Clin Pharmacol , vol.47 , pp. 218-226
    • Kubitza, D.1    Becka, M.2    Zuehlsdorf, M.3    Mueck, W.4
  • 42
    • 78650933761 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of rivaroxaban and its effect on biomarkers of hypercoagulability in patients with chronic heart failure
    • Gheorghiade M., Thyssen A., Zolynas R., et al. Pharmacokinetics and pharmacodynamics of rivaroxaban and its effect on biomarkers of hypercoagulability in patients with chronic heart failure. J Heart Lung Transplant 2011, 30:218-226.
    • (2011) J Heart Lung Transplant , vol.30 , pp. 218-226
    • Gheorghiade, M.1    Thyssen, A.2    Zolynas, R.3
  • 43
    • 78649289929 scopus 로고    scopus 로고
    • Effects of renal impairment on the pharmacokinetics, pharmacodynamics and safety of rivaroxaban, an oral, direct Factor Xa inhibitor
    • Kubitza D., Becka M., Mueck W., et al. Effects of renal impairment on the pharmacokinetics, pharmacodynamics and safety of rivaroxaban, an oral, direct Factor Xa inhibitor. Br J Clin Pharmacol 2010, 70:703-712.
    • (2010) Br J Clin Pharmacol , vol.70 , pp. 703-712
    • Kubitza, D.1    Becka, M.2    Mueck, W.3
  • 44
    • 55549139511 scopus 로고    scopus 로고
    • Dose-escalation study of the pharmacokinetics and pharmacodynamics of rivaroxaban in healthy elderly subjects
    • Kubitza D., Becka M., Roth A., Mueck W. Dose-escalation study of the pharmacokinetics and pharmacodynamics of rivaroxaban in healthy elderly subjects. Curr Med Res Opin 2008, 24:2757-2765.
    • (2008) Curr Med Res Opin , vol.24 , pp. 2757-2765
    • Kubitza, D.1    Becka, M.2    Roth, A.3    Mueck, W.4
  • 45
    • 33947205635 scopus 로고    scopus 로고
    • Rivaroxaban (BAY 59-7939)-an oral, direct Factor Xa inhibitor-has no clinically relevant interaction with naproxen
    • Kubitza D., Becka M., Mueck W., Zuehlsdorf M. Rivaroxaban (BAY 59-7939)-an oral, direct Factor Xa inhibitor-has no clinically relevant interaction with naproxen. Br J Clin Pharmacol 2007, 63:469-476.
    • (2007) Br J Clin Pharmacol , vol.63 , pp. 469-476
    • Kubitza, D.1    Becka, M.2    Mueck, W.3    Zuehlsdorf, M.4
  • 46
    • 64849114048 scopus 로고    scopus 로고
    • Apixaban, an oral direct factor Xa inhibitor, inhibits human clot-bound factor Xa activity in vitro
    • Jiang X., Crain E.J., Luettgen J.M., Schumacher W.A., Wong P.C. Apixaban, an oral direct factor Xa inhibitor, inhibits human clot-bound factor Xa activity in vitro. Thromb Haemost 2009, 101:780-782.
    • (2009) Thromb Haemost , vol.101 , pp. 780-782
    • Jiang, X.1    Crain, E.J.2    Luettgen, J.M.3    Schumacher, W.A.4    Wong, P.C.5
  • 47
    • 79959876326 scopus 로고    scopus 로고
    • Apixaban inhibition of factor Xa: Microscopic rate constants and inhibition mechanism in purified protein systems and in human plasma
    • Luettgen J.M., Knabb R.M., He K., Pinto D.J., Rendina A.R. Apixaban inhibition of factor Xa: Microscopic rate constants and inhibition mechanism in purified protein systems and in human plasma. J Enzyme Inhib Med Chem 2011, 26:514-526.
    • (2011) J Enzyme Inhib Med Chem , vol.26 , pp. 514-526
    • Luettgen, J.M.1    Knabb, R.M.2    He, K.3    Pinto, D.J.4    Rendina, A.R.5
  • 48
    • 84878952383 scopus 로고    scopus 로고
    • Safety, pharmacokinetics and pharmacodynamics of multiple oral doses of apixaban, a factor Xa inhibitor, in healthy subjects
    • Frost C., Nepal S., Wang J., et al. Safety, pharmacokinetics and pharmacodynamics of multiple oral doses of apixaban, a factor Xa inhibitor, in healthy subjects. Br J Clin Pharmacol 2013, 76:776-786.
    • (2013) Br J Clin Pharmacol , vol.76 , pp. 776-786
    • Frost, C.1    Nepal, S.2    Wang, J.3
  • 49
    • 45949103416 scopus 로고    scopus 로고
    • Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty
    • Lassen M.R., Ageno W., Borris L.C., et al. Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty. N Engl J Med 2008, 358:2776-2786.
    • (2008) N Engl J Med , vol.358 , pp. 2776-2786
    • Lassen, M.R.1    Ageno, W.2    Borris, L.C.3
  • 50
    • 36348978071 scopus 로고    scopus 로고
    • The efficacy and safety of apixaban, an oral, direct factor Xa inhibitor, as thromboprophylaxis in patients following total knee replacement
    • Lassen M.R., Davidson B.L., Gallus A., Pineo G., Ansell J., Deitchman D. The efficacy and safety of apixaban, an oral, direct factor Xa inhibitor, as thromboprophylaxis in patients following total knee replacement. J Thromb Haemost 2007, 5:2368-2375.
    • (2007) J Thromb Haemost , vol.5 , pp. 2368-2375
    • Lassen, M.R.1    Davidson, B.L.2    Gallus, A.3    Pineo, G.4    Ansell, J.5    Deitchman, D.6
  • 52
    • 77649113258 scopus 로고    scopus 로고
    • Apixaban versus enoxaparin for thromboprophylaxis after knee replacement (ADVANCE-2): a randomised double-blind trial
    • Lassen M.R., Raskob G.E., Gallus A., Pineo G., Chen D., Hornick P. Apixaban versus enoxaparin for thromboprophylaxis after knee replacement (ADVANCE-2): a randomised double-blind trial. Lancet 2010, 375:807-815.
    • (2010) Lancet , vol.375 , pp. 807-815
    • Lassen, M.R.1    Raskob, G.E.2    Gallus, A.3    Pineo, G.4    Chen, D.5    Hornick, P.6
  • 54
    • 79952301326 scopus 로고    scopus 로고
    • Apixaban in patients with atrial fibrillation
    • Connolly S.J., Eikelboom J., Joyner C., et al. Apixaban in patients with atrial fibrillation. N Engl J Med 2011, 364:806-817.
    • (2011) N Engl J Med , vol.364 , pp. 806-817
    • Connolly, S.J.1    Eikelboom, J.2    Joyner, C.3
  • 55
    • 80052825103 scopus 로고    scopus 로고
    • Apixaban versus warfarin in patients with atrial fibrillation
    • Granger C.B., Alexander J.H., McMurray J.J., et al. Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med 2011, 365:981-992.
    • (2011) N Engl J Med , vol.365 , pp. 981-992
    • Granger, C.B.1    Alexander, J.H.2    McMurray, J.J.3
  • 56
    • 58149458160 scopus 로고    scopus 로고
    • Apixaban metabolism and pharmacokinetics after oral administration to humans
    • Raghavan N., Frost C.E., Yu Z., et al. Apixaban metabolism and pharmacokinetics after oral administration to humans. Drug Metab Dispos 2009, 37:74-81.
    • (2009) Drug Metab Dispos , vol.37 , pp. 74-81
    • Raghavan, N.1    Frost, C.E.2    Yu, Z.3
  • 57
    • 84878921385 scopus 로고    scopus 로고
    • Effect of extremes of body weight on the pharmacokinetics, pharmacodynamics, safety and tolerability of apixaban in healthy subjects
    • Upreti V.V., Wang J., Barrett Y.C., et al. Effect of extremes of body weight on the pharmacokinetics, pharmacodynamics, safety and tolerability of apixaban in healthy subjects. Br J Clin Pharmacol 2013, 76:908-916.
    • (2013) Br J Clin Pharmacol , vol.76 , pp. 908-916
    • Upreti, V.V.1    Wang, J.2    Barrett, Y.C.3
  • 58
    • 76749166335 scopus 로고    scopus 로고
    • In vitro assessment of metabolic drug-drug interaction potential of apixaban through cytochrome P450 phenotyping, inhibition, and induction studies
    • Wang L., Zhang D., Raghavan N., et al. In vitro assessment of metabolic drug-drug interaction potential of apixaban through cytochrome P450 phenotyping, inhibition, and induction studies. Drug Metab Dispos 2010, 38:448-458.
    • (2010) Drug Metab Dispos , vol.38 , pp. 448-458
    • Wang, L.1    Zhang, D.2    Raghavan, N.3
  • 59
    • 79960272135 scopus 로고    scopus 로고
    • Edoxaban: a new oral direct factor xa inhibitor
    • Camm A.J., Bounameaux H. Edoxaban: a new oral direct factor xa inhibitor. Drugs 2011, 71:1503-1526.
    • (2011) Drugs , vol.71 , pp. 1503-1526
    • Camm, A.J.1    Bounameaux, H.2
  • 60
    • 77953787643 scopus 로고    scopus 로고
    • Clinical safety, tolerability, pharmacokinetics, and pharmacodynamics of the novel factor Xa inhibitor edoxaban in healthy volunteers
    • Ogata K., Mendell-Harary J., Tachibana M., Masumoto H., Oguma T., Kojima M., Kunitada S. Clinical safety, tolerability, pharmacokinetics, and pharmacodynamics of the novel factor Xa inhibitor edoxaban in healthy volunteers. J Clin Pharmacol 2010, 50:743-753.
    • (2010) J Clin Pharmacol , vol.50 , pp. 743-753
    • Ogata, K.1    Mendell-Harary, J.2    Tachibana, M.3    Masumoto, H.4    Oguma, T.5    Kojima, M.6    Kunitada, S.7
  • 61
    • 84889805341 scopus 로고    scopus 로고
    • Postmarketing safety experience with edoxaban in Japan for thromboprophylaxis following major orthopedic surgery
    • Kuroda Y., Hirayama C., Hotoda H., Nishikawa Y., Nishiwaki A. Postmarketing safety experience with edoxaban in Japan for thromboprophylaxis following major orthopedic surgery. Vasc Health Risk Manag 2013, 9:593-598.
    • (2013) Vasc Health Risk Manag , vol.9 , pp. 593-598
    • Kuroda, Y.1    Hirayama, C.2    Hotoda, H.3    Nishikawa, Y.4    Nishiwaki, A.5
  • 62
    • 84885618705 scopus 로고    scopus 로고
    • Edoxaban versus warfarin for the treatment of symptomatic venous thromboembolism
    • Buller H.R., Decousus H., Grosso M.A., et al. Edoxaban versus warfarin for the treatment of symptomatic venous thromboembolism. N Engl J Med 2013, 369:1406-1415.
    • (2013) N Engl J Med , vol.369 , pp. 1406-1415
    • Buller, H.R.1    Decousus, H.2    Grosso, M.A.3
  • 63
    • 84888362796 scopus 로고    scopus 로고
    • Edoxaban versus warfarin in patients with atrial fibrillation
    • Giugliano R.P., Ruff C.T., Braunwald E., et al. Edoxaban versus warfarin in patients with atrial fibrillation. N Engl J Med 2013, 369:2093-2104.
    • (2013) N Engl J Med , vol.369 , pp. 2093-2104
    • Giugliano, R.P.1    Ruff, C.T.2    Braunwald, E.3
  • 64
    • 79955531668 scopus 로고    scopus 로고
    • Effects of food on the pharmacokinetics of edoxaban, an oral direct factor Xa inhibitor, in healthy volunteers
    • Mendell J., Tachibana M., Shi M., Kunitada S. Effects of food on the pharmacokinetics of edoxaban, an oral direct factor Xa inhibitor, in healthy volunteers. J Clin Pharmacol 2011, 51:687-694.
    • (2011) J Clin Pharmacol , vol.51 , pp. 687-694
    • Mendell, J.1    Tachibana, M.2    Shi, M.3    Kunitada, S.4
  • 65
    • 84869109465 scopus 로고    scopus 로고
    • Pharmacokinetics, biotransformation, and mass balance of edoxaban, a selective, direct factor Xa inhibitor, in humans
    • Bathala M.S., Masumoto H., Oguma T., He L., Lowrie C., Mendell J. Pharmacokinetics, biotransformation, and mass balance of edoxaban, a selective, direct factor Xa inhibitor, in humans. Drug Metab Dispos 2012, 40:2250-2255.
    • (2012) Drug Metab Dispos , vol.40 , pp. 2250-2255
    • Bathala, M.S.1    Masumoto, H.2    Oguma, T.3    He, L.4    Lowrie, C.5    Mendell, J.6
  • 66
    • 84860526602 scopus 로고    scopus 로고
    • Modelling and simulation of edoxaban exposure and response relationships in patients with atrial fibrillation
    • Salazar D.E., Mendell J., Kastrissios H., et al. Modelling and simulation of edoxaban exposure and response relationships in patients with atrial fibrillation. Thromb Haemost 2012, 107:925-936.
    • (2012) Thromb Haemost , vol.107 , pp. 925-936
    • Salazar, D.E.1    Mendell, J.2    Kastrissios, H.3
  • 67
    • 84885129987 scopus 로고    scopus 로고
    • Drug-drug interaction studies of cardiovascular drugs involving P-glycoprotein, an efflux transporter, on the pharmacokinetics of edoxaban, an oral factor Xa inhibitor
    • Mendell J., Zahir H., Matsushima N., et al. Drug-drug interaction studies of cardiovascular drugs involving P-glycoprotein, an efflux transporter, on the pharmacokinetics of edoxaban, an oral factor Xa inhibitor. Am J Cardiovasc Drugs 2013, 13:331-342.
    • (2013) Am J Cardiovasc Drugs , vol.13 , pp. 331-342
    • Mendell, J.1    Zahir, H.2    Matsushima, N.3
  • 68
    • 84883301339 scopus 로고    scopus 로고
    • The effects of the antiplatelet agents, aspirin and naproxen, on pharmacokinetics and pharmacodynamics of the anticoagulant edoxaban, a direct factor Xa inhibitor
    • Mendell J., Lee F., Chen S., Worland V., Shi M., Samama M.M. The effects of the antiplatelet agents, aspirin and naproxen, on pharmacokinetics and pharmacodynamics of the anticoagulant edoxaban, a direct factor Xa inhibitor. J Cardiovasc Pharmacol 2013, 62:212-221.
    • (2013) J Cardiovasc Pharmacol , vol.62 , pp. 212-221
    • Mendell, J.1    Lee, F.2    Chen, S.3    Worland, V.4    Shi, M.5    Samama, M.M.6
  • 69
    • 84867747564 scopus 로고    scopus 로고
    • Pharmacokinetics of the direct factor Xa inhibitor edoxaban and digoxin administered alone and in combination
    • Mendell J., Noveck R.J., Shi M. Pharmacokinetics of the direct factor Xa inhibitor edoxaban and digoxin administered alone and in combination. J Cardiovasc Pharmacol 2012, 60:335-341.
    • (2012) J Cardiovasc Pharmacol , vol.60 , pp. 335-341
    • Mendell, J.1    Noveck, R.J.2    Shi, M.3
  • 70
    • 0031955043 scopus 로고    scopus 로고
    • Comparison of a once daily with a twice daily subcutaneous low molecular weight heparin regimen in the treatment of deep vein thrombosis. FRAXODI group
    • Charbonnier B.A., Fiessinger J.N., Banga J.D., Wenzel E., D'Azemar P., Sagnard L. Comparison of a once daily with a twice daily subcutaneous low molecular weight heparin regimen in the treatment of deep vein thrombosis. FRAXODI group. Thromb Haemost 1998, 79:897-901.
    • (1998) Thromb Haemost , vol.79 , pp. 897-901
    • Charbonnier, B.A.1    Fiessinger, J.N.2    Banga, J.D.3    Wenzel, E.4    D'Azemar, P.5    Sagnard, L.6
  • 71
    • 78650965540 scopus 로고    scopus 로고
    • Effects of the oral, direct factor Xa inhibitor rivaroxaban on commonly used coagulation assays
    • Hillarp A., Baghaei F., Fagerberg Blixter I., et al. Effects of the oral, direct factor Xa inhibitor rivaroxaban on commonly used coagulation assays. J Thromb Haemost 2011, 9:133-139.
    • (2011) J Thromb Haemost , vol.9 , pp. 133-139
    • Hillarp, A.1    Baghaei, F.2    Fagerberg Blixter, I.3
  • 72
    • 79851482951 scopus 로고    scopus 로고
    • Effects of the oral, direct thrombin inhibitor dabigatran on five common coagulation assays
    • Lindahl T.L., Baghaei F., Blixter I.F., et al. Effects of the oral, direct thrombin inhibitor dabigatran on five common coagulation assays. Thromb Haemost 2011, 105:371-378.
    • (2011) Thromb Haemost , vol.105 , pp. 371-378
    • Lindahl, T.L.1    Baghaei, F.2    Blixter, I.F.3


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