Population pharmacokinetic analysis of the oral thrombin inhibitor dabigatran etexilate in patients with non-valvular atrial fibrillation from the RE-LY trial

Journal of Thrombosis and Haemostasis

Volumn 9, Issue 11, 2011, Pages 2168-2175

  Liesenfeld, K H ^a   Lehr, T ^a   Dansirikul, C ^a   Reilly, P A ^b   Connolly, S J ^c   Ezekowitz, M D ^d   Yusuf, S ^c   Wallentin, L ^e   Haertter, S ^a   Staab, A ^a  

^a BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^b BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

^c MCMASTER UNIVERSITY   (Canada)

^d LANKENAU INSTITUTE FOR MEDICAL RESEARCH   (United States)

^e UPPSALA UNIVERSITY   (Sweden)

Author keywords

Dabigatran etexilate; Non valvular atrial fibrillation; Nonmem; Population pharmacokinetics; RE LY; Thrombin inhibitor

Indexed keywords

AMIODARONE; CREATININE; DABIGATRAN ETEXILATE; DILTIAZEM; HEMOGLOBIN; PROTON PUMP INHIBITOR; VERAPAMIL; WARFARIN;

AGED; ANTICOAGULANT THERAPY; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; CREATININE CLEARANCE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; EMBOLISM; EMBOLISM PREVENTION; FEMALE; FOLLOW UP; HEART ATRIUM FIBRILLATION; HEART FAILURE; HUMAN; KIDNEY FUNCTION; LONG TERM CARE; MAJOR CLINICAL STUDY; MALE; NONVALVULAR ATRIAL FIBRILLATION; OPEN STUDY; OUTCOME ASSESSMENT; PHARMACOLOGICAL PARAMETERS; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; STEADY STATE; STROKE;

ADULT; AGED; AGED, 80 AND OVER; ATRIAL FIBRILLATION; BENZIMIDAZOLES; BODY WEIGHT; DRUG INTERACTIONS; ETHNIC GROUPS; HEMOGLOBINS; HUMANS; KIDNEY DISEASES; MIDDLE AGED; MODELS, THEORETICAL; PHARMACOKINETICS; PLASMA; PRODRUGS; PYRIDINES; THROMBIN; YOUNG ADULT;

EID: 80055122488     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2011.04498.x     Document Type: Article

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