Nox2 mediates high fat high sucrose diet-induced nitric oxide dysfunction and inflammation in aortic smooth muscle cells

Journal of Molecular and Cellular Cardiology

Volumn 72, Issue , 2014, Pages 56-63

  Qin, Zhexue ^a,b   Hou, Xiuyun ^a   Weisbrod, Robert M ^a   Seta, Francesca ^a   Cohen, Richard A ^a   Tong, Xiaoyong ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

High fat high sucrose diet; Nitric oxide; Nox2; Smooth muscle cell

Indexed keywords

CATALASE; COPPER ZINC SUPEROXIDE DISMUTASE; GLUTATHIONE PEROXIDASE 1; MANGANESE SUPEROXIDE DISMUTASE; NITRIC OXIDE; PROTEIN P22; RAC1 PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE 2B; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; ATP2A2 PROTEIN, MOUSE; CYBB PROTEIN, MOUSE; MEMBRANE PROTEIN; REACTIVE OXYGEN METABOLITE; SUCROSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; CARDIOVASCULAR DISEASE; CELL MIGRATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME METABOLISM; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LIPID DIET; MALE; MOUSE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; RESTENOSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOOTH MUSCLE FIBER; SUGAR INTAKE; UPREGULATION; ANIMAL; AORTA; C57BL MOUSE; CELL MOTION; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLIC SYNDROME X; METABOLISM; OBESITY; OXIDATION REDUCTION REACTION; PATHOLOGY; PRIMARY CELL CULTURE; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM;

ANIMALS; AORTA; CELL MOVEMENT; DIET, HIGH-FAT; ENDOTHELIUM, VASCULAR; GENE EXPRESSION REGULATION; INFLAMMATION; MALE; MEMBRANE GLYCOPROTEINS; METABOLIC SYNDROME X; MICE; MICE, INBRED C57BL; MYOCYTES, SMOOTH MUSCLE; NADPH OXIDASE; NITRIC OXIDE; OBESITY; OXIDATION-REDUCTION; PRIMARY CELL CULTURE; REACTIVE OXYGEN SPECIES; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; SIGNAL TRANSDUCTION; SUCROSE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84901359981     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2014.02.019     Document Type: Article

References (36)

1. Ying J., Tong X., Pimentel D.R., Weisbrod R.M., Trucillo M.P., Adachi T., et al. Cysteine-674 of the sarco/endoplasmic reticulum calcium ATPase is required for the inhibition of cell migration by nitric oxide. Arterioscler Thromb Vasc Biol 2007, 27:783-790.
2. Tong X., Hou X., Jourd'heuil D., Weisbrod R.M., Cohen R.A. Upregulation of Nox4 by TGF{beta}1 oxidizes SERCA and inhibits NO in arterial smooth muscle of the prediabetic Zucker rat. Circ Res 2010, 107:975-983.
3. Tong X., Schröder K. NADPH oxidases are responsible for the failure of nitric oxide to inhibit migration of smooth muscle cells exposed to high glucose. Free Radic Biol Med 2009, 47:1578-1583.
4. Tong X., Ying J., Pimentel D.R., Trucillo M., Adachi T., Cohen R.A. High glucose oxidizes SERCA cysteine-674 and prevents inhibition by nitric oxide of smooth muscle cell migration. J Mol Cell Cardiol 2008, 44:361-369.
5. Griendling K.K., Sorescu D., Ushio-Fukai M. NAD(P)H oxidase: role in cardiovascular biology and disease. Circ Res 2000, 86:494-501.
6. Ago T., Kuroda J., Kamouchi M., Sadoshima J., Kitazono T. Pathophysiological roles of NADPH oxidase/nox family proteins in the vascular system. Review and perspective. Circ J 2011, 75:1791-1800.
7. Von Löhneysen K., Noack D., Wood M.R., Friedman J.S., Knaus U.G. Structural insights into Nox4 and Nox2: motifs involved in function and cellular localization. Mol Cell Biol 2010, 30:961-975.
8. Konior A., Schramm A., Czesnikiewicz-Guzik M., Guzik T.J. NADPH oxidases in vascular pathology. Antioxid Redox Signal 2013, [00].
9. Ambasta R.K., Kumar P., Griendling K.K., Schmidt H.H.H.W., Busse R., Brandes R.P. Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase. J Biol Chem 2004, 279:45935-45941.
10. Martyn K.D., Frederick L.M., von Loehneysen K., Dinauer M.C., Knaus U.G. Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases. Cell Signal 2006, 18:69-82.
11. Meng D., Lv D.-D., Fang J. Insulin-like growth factor-I induces reactive oxygen species production and cell migration through Nox4 and Rac1 in vascular smooth muscle cells. Cardiovasc Res 2008, 80:299-308.
12. Weisbrod R.M., Shiang T., Al Sayah L., Fry J.L., Bajpai S., Reinhart-King C.a, et al. Arterial stiffening precedes systolic hypertension in diet-induced obesity. Hypertension 2013, 62:1105-1110.
13. Qin F., Siwik D.A., Luptak I., Hou X., Wang L., Higuchi A., et al. The polyphenols resveratrol and S17834 prevent the structural and functional sequelae of diet-induced metabolic heart disease in mice. Circulation 2012, 125:1757-1764.
14. Barnard R.J., Faria D.J., Menges J.E., Martin D.A. Effects of a high-fat, sucrose diet on serum insulin and related atherosclerotic risk factors in rats. Atherosclerosis 1993, 100:229-236.
15. Xi S., Yin W., Wang Z., Kusunoki M., Lian X., Koike T., et al. A minipig model of high-fat/high-sucrose diet-induced diabetes and atherosclerosis. Int J Exp Pathol 2004, 85:223-231.
16. Schreyer S.A., Lystig T.C., Vick C.M., LeBoeuf R.C. Mice deficient in apolipoprotein E but not LDL receptors are resistant to accelerated atherosclerosis associated with obesity. Atherosclerosis 2003, 171:49-55.
17. Li Y., Xu S., Mihaylova M.M., Zheng B., Hou X., Jiang B., et al. AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab 2011, 13:376-388.
18. Nyalala J.O., Luo S., Campbell D.N., Brown A.T., Moursi M.M. The effects of acarbose treatment on intimal hyperplasia in a rat carotid endarterectomy model of diet-induced insulin resistance. Vasc Endovascular Surg 2010, 44:560-567.
19. Zhang Y., Yuan M., Bradley K.M., Dong F., Anversa P., Ren J. Insulin-like growth factor 1 alleviates high-fat diet-induced myocardial contractile dysfunction: role of insulin signaling and mitochondrial function. Hypertension 2012, 59:680-693.
20. Editor D. Letter to the Editor Akt 2 knockout preserves cardiac function in high-fat diet-induced obesity by rescuing cardiac autophagosome maturation 2013, 61-63.
21. Omar B., Pacini G., Ahrén B. Differential development of glucose intolerance and pancreatic islet adaptation in multiple diet induced obesity models. Nutrients 2012, 4:1367-1381.
22. Surwit R.S., Kuhn C.M., Cochrane C., McCubbin J.A., Feinglos M.N. Diet-induced type II diabetes in C57BL/6J mice. Diabetes 1988, 37:1163-1167.
23. Adachi T., Matsui R., Weisbrod R.M., Najibi S., Cohen R.A. Reduced sarco/endoplasmic reticulum Ca(2+) uptake activity can account for the reduced response to NO, but not sodium nitroprusside, in hypercholesterolemic rabbit aorta. Circulation 2001, 104:1040-1045.
24. Zhao H., Kalivendi S., Zhang H., Joseph J., Nithipatikom K., Vásquez-Vivar J., et al. Superoxide reacts with hydroethidine but forms a fluorescent product that is distinctly different from ethidium: potential implications in intracellular fluorescence detection of superoxide. Free Radic Biol Med 2003, 34:1359-1368.
25. Bayat H., Xu S., Pimentel D., Cohen R.A., Jiang B. Activation of thromboxane receptor upregulates interleukin (IL)-1beta-induced VCAM-1 expression through JNK signaling. Arterioscler Thromb Vasc Biol 2008, 28:127-134.
26. Wang H.-W., Liu P.-Y., Oyama N., Rikitake Y., Kitamoto S., Gitlin J., et al. Deficiency of ROCK1 in bone marrow-derived cells protects against atherosclerosis in LDLR-/- mice. FASEB J 2008, 22:3561-3570.
27. Adachi T., Weisbrod R.M., Pimentel D.R., Ying J., Sharov V.S., Schöneich C., et al. S-Glutathiolation by peroxynitrite activates SERCA during arterial relaxation by nitric oxide. Nat Med 2004, 10:1200-1207.
28. Simon D.I. Inflammation and vascular injury. Circ J 2012, 76:1811-1818.
29. Hopkins P.N. Molecular biology of atherosclerosis. Physiol Rev 2013, 93:1317-1542.
30. Stamatelopoulos K., Karatzi K., Sidossis L.S. Noninvasive methods for assessing early markers of atherosclerosis: the role of body composition and nutrition. Curr Opin Clin Nutr Metab Care 2009, 12:467-473.
31. Barry-Lane P.A., Patterson C., van der Merwe M., Hu Z., Holland S.M., Yeh E.T., et al. p47phox is required for atherosclerotic lesion progression in ApoE(-/-) mice. J Clin Invest 2001, 108:1513-1522.
32. -/- mice. Am J Physiol Heart Circ Physiol 2010, 298:H24-H32.
33. Gray S.P., Di Marco E., Okabe J., Szyndralewiez C., Heitz F., Montezano A.C., et al. Nox1 plays a key role in diabetes accelerated atherosclerosis. Circulation 2013, 127:1888-1902.
34. Molnar J., Yu S., Mzhavia N., Pau C., Chereshnev I., Dansky H.M. Diabetes induces endothelial dysfunction but does not increase neointimal formation in high-fat diet fed C57BL/6J mice. Circ Res 2005, 96:1178-1184.
35. Bendall J.K., Rinze R., Adlam D., Tatham A.L., de Bono J., Wilson N., et al. Endothelial Nox2 overexpression potentiates vascular oxidative stress and hemodynamic response to angiotensin II: studies in endothelial-targeted Nox2 transgenic mice. Circ Res 2007, 100:1016-1025.
36. - mice. Cardiovasc Res 2012, 94:20-29.