COMT Val158Met and PPARγ Pro12Ala polymorphisms and susceptibility to Alzheimer's disease: A meta-analysis

Neurological Sciences

Volumn 35, Issue 5, 2014, Pages 643-651

  Lee, Young Ho ^a   Song, Gwan Gyu ^a  

^a Korea University College of Medicine   (South Korea)

Author keywords

Alzheimer's disease; COMT; Meta analysis; Polymorphism; PPAR

Indexed keywords

ALANINE; CATECHOL METHYLTRANSFERASE; METHIONINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROLINE; VALINE; COMT PROTEIN, HUMAN;

ALLELE; ALZHEIMER DISEASE; DISEASE PREDISPOSITION; ETHNICITY; GENETIC POLYMORPHISM; GENOTYPE; HOMOZYGOTE; HUMAN; REVIEW; ASIAN CONTINENTAL ANCESTRY GROUP; CAUCASIAN; GENETIC PREDISPOSITION; GENETICS; META ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM;

ALZHEIMER DISEASE; ASIAN CONTINENTAL ANCESTRY GROUP; CATECHOL O-METHYLTRANSFERASE; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENETIC PREDISPOSITION TO DISEASE; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE; PPAR GAMMA;

EID: 84901347534     PISSN: 15901874     EISSN: 15903478     Source Type: Journal    
DOI: 10.1007/s10072-014-1645-4     Document Type: Review

References (34)

1. Bertram L, Tanzi RE (2012) The genetics of Alzheimer's disease. Prog Mol Biol Transl Sci 107:79-100
2. Li H, Wetten S, Li L, St Jean PL, Upmanyu R, Surh L et al (2008) Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease. Arch Neurol 651:45-53
3. Kaenmaki M, Tammimaki A, Myohanen T, Pakarinen K, Amberg C, Karayiorgou M et al (2010) Quantitative role of COMT in dopamine clearance in the prefrontal cortex of freely moving mice. J Neurochem 114(6):1745-1755
4. Lachman HM, Papolos DF, Saito T, Yu YM, Szumlanski CL, Weinshilboum RM (1996) Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics 6(3):243-250 (Pubitemid 26226317)
5. Beaven SW, Tontonoz P (2006) Nuclear receptors in lipid metabolism: targeting the heart of dyslipidemia. Annu Rev Med 57:313-329 (Pubitemid 43261994)
6. Wang HM, Zhao YX, Zhang S, Liu GD, Kang WY, Tang HD et al (2010) PPARc agonist curcumin reduces the amyloid-beta-stimulated inflammatory responses in primary astrocytes. J Alzheimers Dis 20(4):1189-1199
7. Deeb SS, Fajas L, Nemoto M, Pihlajamaki J, Mykkanen L, Kuusisto J et al (1998) A Pro12Ala substitution in PPARγ 2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. Nat Genet 20(3):284-287 (Pubitemid 28507675)
8. Knouff C, Auwerx J (2004) Peroxisome proliferator-activated receptor-gamma calls for activation in moderation: lessons from genetics and pharmacology. Endocr Rev 25(6):899-918 (Pubitemid 39657772)
9. Tonjes A, Stumvoll M (2007) The role of the Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma in diabetes risk. Curr Opin Clin Nutr Metab Care 10(4):410-414 (Pubitemid 46934108)
10. Lanni C, Garbin G, Lisa A, Biundo F, Ranzenigo A, Sinforiani E et al (2012) Influence of COMT Val158Met polymorphism on Alzheimer's disease and mild cognitive impairment in Italian patients. J Alzheimers Dis 32(4):919-926
11. Martinez MF, Martin XE, Alcelay LG, Flores JC, Valiente JMU, Juanbeltz BI, et al. (2009) The COMT Val158 Met polymorphism as an associated risk factor for Alzheimer disease and mild cognitive impairment in APOE 4 carriers. BMC Neurosci 10:1-9
12. Wang PN, Liu HC, Liu TY, Chu A, Hong CJ, Lin KN et al (2005) Estrogen-metabolizing gene COMT polymorphism synergistic APOE epsilon 4 allele increases the risk of Alzheimer disease. Dement Geriatr Cogn Disord 19(2-3):120-125 (Pubitemid 40868038)
13. Borroni B, Agosti C, Archetti S, Costanzi C, Bonomi S, Ghianda D et al (2004) Catechol-O-methyltransferase gene polymorphism is associated with risk of psychosis in Alzheimer disease. Neurosci Lett 370(2-3):127-129 (Pubitemid 39370865)
14. Thornton V, Warden D, Talbot C, Mastana SS, Bandelow S, Hogervorst E (2011) Modification of estrogen's association with Alzheimer's disease risk by genetic polymorphisms. Brain Res 1379:213-223
15. Forero DA, Benitez B, Arboleda G, Yunis JJ, Pardo R, Arboleda H (2006) Analysis of functional polymorphisms in three synaptic plasticity-related genes (BDNF, COMT AND UCHL1) in Alzheimer's disease in Colombia. Neurosci Res 55(3):334-341 (Pubitemid 43766406)
16. Combarros O, Rodriguez-Rodriguez E, Mateo I, Vazquez-Higuera JL, Infante J, Berciano J et al (2011) APOE dependent-association of PPAR-(gamma) genetic variants with Alzheimer's disease risk. Neurobiol Aging 32(3):547.e1-547.e6
17. Sauder S, Kolsch H, Lutjohann D, Schulz A, Von Bergmann K, Maier W et al (2005) Influence of peroxisome proliferator-activated receptor (gamma) gene polymorphism on 24S-hydroxycholesterol levels in Alzheimer's patients. J Neural Transm 112(10):1381-1389 (Pubitemid 41355966)
18. Helisalmi S, Tarvainen T, Vepsalainen S, Koivisto AM, Hiltunen M, Soininen H (2008) Lack of genetic association between PPARG gene polymorphisms and Finnish late-onset Alzheimer's disease. Neurosci Lett 441(2):233-236
19. Shibata N, Motoi Y, Tomiyama H, Ohnuma T, Kuerban B, Tomson K et al (2013) Lack of genetic associations of PPAR-gamma and PGC-1alpha with Alzheimer's disease and Parkinson's disease with dementia. Dement Geriatr Cogn Dis Extra 3(1):161-167
20. Zhou J, Li XM, Jiang T, Liu Y, Chi S, Yu JT, et al. (2013) Lack of association between COMT Val158Met polymorphism and late-onset Alzheimer's disease in Han Chinese. Neurosci Lett 25:162-166
21. Lee YH, Harley JB, Nath SK (2006) Meta-analysis of TNF-alpha promoter-308 A/G polymorphism and SLE susceptibility. Eur J Hum Genet 14(3):364-371
22. Lee YH, Witte T, Momot T, Schmidt RE, Kaufman KM, Harley JB et al (2005) The mannose-binding lectin gene polymorphisms and systemic lupus erythematosus: two case-control studies and a meta-analysis. Arthritis Rheum 52(12):3966-3974 (Pubitemid 41798236)
23. Lee YH, Nath SK (2005) Systemic lupus erythematosus susceptibility loci defined by genome scan meta-analysis. Hum Genet 118(3-4):434-443 (Pubitemid 43091214)
24. Higgins JP, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21(11):1539-1558 (Pubitemid 34746062)
25. DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7(3):177-188 (Pubitemid 17189972)
26. Egger M, Smith GD, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315(7109):629-634 (Pubitemid 27387172)
27. Lin WY, Wu BT, Lee CC, Sheu JJ, Liu WF, Wang WF et al (2012) Association analysis of dopaminergic gene variants (COMT, DRD4 and DAT1) with Alzheimer's disease. J Biol Regul Homeost Agents 26(3):401-410
28. Pereira PA, Romano-Silva MA, Bicalho MAC, De Moraes EN, Malloy-Diniz L, Pimenta GJGS et al (2012) Catechol-o-methyl-transferase genetic variant associated with the risk of Alzheimer's disease in a Brazilian population. Dement Geriatr Cogn Disord 34(2):90-95
29. Koivisto AM, Helisalmi S, Pihlajamaki J, Hiltunen M, Koivisto K, Moilanen L et al (2006) Association analysis of peroxisome proliferator-activated receptor gamma polymorphisms and late onset Alzheimer's disease in the Finnish population. Dement Geriatr Cogn Disord 22(5-6):449-453 (Pubitemid 44726016)
30. Serretti A, Olgiati P (2012) Catechol-O-Methyltransferase and Alzheimer's disease: a review of biological and genetic findings. CNS Neurol Disord Drug Targets 11(3):299-305
31. Egan MF, Goldberg TE, Kolachana BS, Callicott JH, Mazzanti CM, Straub RE et al (2001) Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci USA 98(12):6917-6922 (Pubitemid 32538317)
32. Zhu Y, Qi C, Korenberg JR, Chen XN, Noya D, Rao MS et al (1995) Structural organization of mouse peroxisome proliferator-activated receptor gamma (mPPAR gamma) gene: alternative promoter use and different splicing yield two mPPAR gamma isoforms. Proc Natl Acad Sci USA 92(17):7921-7925
33. Kishikawa S, Li JL, Gillis T, Hakky MM, Warby S, Hayden M et al (2006) Brain-derived neurotrophic factor does not influence age at neurologic onset of Huntington's disease. Neurobiol Dis 24(2):280-285 (Pubitemid 44572754)
34. Lu L, Su Y, Hou P, Huang C (2013) The COMT Val158Met polymorphism as an associated risk factor for Parkinson's disease in Asian rather than Caucasian populations. Neurol India 61(1):12-16