Effect of bevacizumab combined with boron neutron capture therapy on local tumor response and lung metastasis

Experimental and Therapeutic Medicine

Volumn 8, Issue 1, 2014, Pages 291-301

  Masunaga, Shin Ichiro ^a   Sakurai, Yoshinori ^a   Tano, Keizo ^a   Tanaka, Hiroki ^a   Suzuki, Minoru ^a   Kondo, Natsuko ^a   Narabayashi, Masaru ^a   Watanabe, Tsubasa ^a   Nakagawa, Yosuke ^a   Maruhashi, Akira ^a   Ono, Koji ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Bevacizumab; Boron neutron capture therapy; Mild temperature hyperthermia; Nicotinamide; Quiescent cell

Indexed keywords

BEVACIZUMAB; BORON 10; BROXURIDINE; NICOTINAMIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRDU ASSAY; CLONOGENESIS; FEMALE; IMMUNOFLUORESCENCE TEST; IRRADIATION; LUNG METASTASIS; MALIGNANT HYPERTHERMIA; MELANOMA; NEUTRON CAPTURE THERAPY; NONHUMAN; SINGLE DRUG DOSE;

EID: 84901328478     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2014.1704     Document Type: Article

References (33)

1. Barth RF, Coderre JA, Vicente MG and Blue TE: Boron neutron capture therapy of cancer: current status and future prospects. Clin Cancer Res 11: 3987-4002, 2005.
2. Soloway AH, Hatanaka H and Davis MA: Penetration of brain and brain tumor. VII. Tumor-binding sulfhydryl boron compounds. J Med Chem 10: 714-717, 1967.
3. Coderre JA, Turcotte JC, Riley KJ, Binns PJ, Harling OK and Kiger WS: Boron neutron capture therapy: cellular targeting of high linear energy transfer radiation. Technol Cancer Res Treat 2: 355-375, 2003.
4. Wittig A, Sauerwein WA and Coderre JA: Mechanisms of transport of p-borono-phenylalanine through the cell membrane in vitro. Radiat Res 153: 173-180, 2000.
5. Miyatake S, Kawabata S, Kajimoto Y, et al: Modified boron neutron capture therapy for malignant gliomas performed using epithermal neutron and two boron compounds with different accumulation mechanisms: an efficacy study based on findings on neuroimages. J Neurosurg 103: 1000-1009, 2005.
6. Jain RK: Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 307: 58-62, 2005.
7. Winkler F, Kozin SV, Tong RT, et al: Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matix metalloproteinases. Cancer Cell 6: 553-563, 2004.
8. Brown JM: Evidence for acutely hypoxic cells in mouse tumours, and a possible mechanism of reoxygenation. Br J Radiol 52: 650-656, 1979.
9. Cairns BA, Kalliomaki T and Hill RP: Acute (cyclic) hypoxia enhances spontaneous metastasis of KHT murine tumors. Cancer Res 61: 8903-8908, 2001.
10. Rofstad EK, Galappathi K, Mathiesen B and Ruud EB: Fluctuating and diffusion-limited hypoxia in hypoxia-induced metastasis. Clin Cancer Res 13: 1971-1978, 2007.
11. Masunaga S, Ono K, Suzuki M, et al: Alteration in the hypoxic fraction of quiescent cell populations by hyperthermia at mild temperatures. Int J Hyperthermia 13: 401-411, 1997.
12. Masunaga S, Matsumoto Y, Hirayama R, et al: Significance of manipulating intratumor hypoxia in the effect on lung metastases in radiotherapy, with reference to its effect on the sensitivity of intratumor quiescent cells. Clin Exp Metastasis 26: 693-700, 2009.
13. Masunaga S and Ono K: Significance of the response of quiescent cell populations within solid tumors in cancer therapy. J Radiat Res 43: 11-25, 2002.
14. Duan X, Zhang H, Liu B, Li XD, Gao QX and Wu ZH: Apoptosis of murine melanoma cells induced by heavy-ion radiation combined with Tp53 gene transfer. Int J Radiat Biol 84: 211-217, 2008.
15. Dings RP, Loren M, Heun H, et al: Scheduling of radiation with angiogenesis inhibitors anginex and Avastin improves therapeutic outcome via vessel normalization. Clin Cancer Res 13: 3395-3402, 2007.
16. Masunaga S, Ono K, Sakurai Y, et al: Evaluation of apoptosis and micronucleation induced by reactor neutron beams with two different cadmium ratios in total and quiescent cell populations within solid tumors. Int J Radiat Oncol Biol Phys 51: 828-839, 2001.
17. Kobayashi T and Kanda K: Microanalysis system of ppm-order B-10 concentrations in tissue for neutron capture therapy by prompt γ-ray spectrometry. Nucl Instrum Methods Phys Res 204: 525-531, 1983.
18. Nishimura Y, Ono K, Hiraoka M, et al: Treatment of murine SCC VII tumors with localized hyperthermia and temperature-sensitive liposomes containing cisplatin. Radiat Res 122: 161-167, 1990.
19. Sakurai Y and Kobayashi T. Characteristics of the KUR heavy water neutron irradiation facility as a neutron irradiation field with variable energy spectra. Nucl Instr Meth A 453: 569-596, 2000.
20. Kobayashi T, Sakurai Y, Kanda K, Fujita Y and Ono K: The remodeling and basic characteristics of the heavy water neutron irradiation facility of the Kyoto University Research Reactor, mainly for neutron capture therapy. Nucl Tech 131: 354-378, 2000.
21. Snyder WS, Cook MJ, Nasset ES, Karhausen LR, Parry Howells G and Tipton I: Gross and elemental content of reference man. In: Report of the task group on reference man. Snyder WS (ed). Pergamon Press, Oxford, UK: pp273-324, 1975.
22. De Jaeger K, Kavanagh MC and Hill RP: Relationship of hypoxia to metastatic ability in rodent tumours. Br J Cancer 84: 1280-1285, 2001.
23. Hall EJ: Time, Dose, and Fractionation in Radiotherapy. In: Radiobiology for the Radiologist. Hall EJ and Giaccia AJ, (eds). 7th edition. Lippincott Williams & Wilkins, Philadelphia, PA, USA, pp 391-411, 2012.
24. Vaupel P: Tumor microenvironmental physiology and its implications for radiation oncology. Semin Radiat Oncol 14: 198-206, 2004.
25. Vaupel P, Kallinowski F and Okunieff P: Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res 49: 6449-6465, 1989.
26. Chaplin DJ, Horsman MR and Trotter MJ: Effect of nicotinamide on the microregional heterogeneity of oxygen delivery within a murine tumor. J Natl Cancer Inst 82: 672-676, 1990.
27. Song CW, Park H and Griffin RJ: Improvement of tumor oxygenation by mild hyperthermia. Radiat Res 155: 512-528, 2001.
28. Presta LG, Chen H, O'Conner SJ, et al: Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders. Cancer Res 57: 4593-4599, 1997.
29. Ma J and Waxman DJ. Combination of antiangiogenesis with chemotherapy for more effective cancer treatment. Mol Cancer Ther 7: 3670-3684, 2008.
30. Jain RK, Tong RT and Munn LL. Effect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: insights from a mathematical model. Cancer Res 67: 2729-2735, 2007.
31. Molinari AJ, Pozzi EC, Monti Hughes A, et al: Tumor blood vessel "normalization" improves the therapeutic efficacy of boron neutron capture therapy (BNCT) in experimental oral cancer. Radiat Res 177: 59-68, 2012.
32. Ando K, Koike S, Ohira C, et al: Accelerated reoxygenation of a murine fibrosarcoma after carbon-ion radiation. Int J Radiat Biol 75: 505-512, 1999.
33. Möller MG, Lewis JM, Dessureault S and Zager JS: Toxicities associated with hyperthermic isolated limb perfusion and isolated limb infusion in the treatment of melanoma and sarcoma. Int J Hyperthermia 24: 275-89, 2008.