18F-ASEM, a radiolabeled antagonist for imaging the aα7-nicotinic acetylcholine receptor with PET

Journal of Nuclear Medicine

Volumn 55, Issue 4, 2014, Pages 672-677

  Horti, Andrew G ^a   Gao, Yongjun ^a   Kuwabara, Hiroto ^a   Wang, Yuchuan ^a   Abazyan, Sofya ^a   Yasuda, Robert P ^b   Tran, Thao ^b   Xiao, Yingxian ^b   Sahibzada, Niaz ^b   Holt, Daniel P ^a   Kellar, Kenneth J ^b   Pletnikov, Mikhail V ^a   Pomper, Martin G ^a   Wong, Dean F ^a   Dannals, Robert F ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b GEORGETOWN UNIVERSITY   (United States)

Author keywords

Baboon; Nicotine; PET; 7 nAChR

Indexed keywords

1,4 DIAZABICYCLO[3.2.2]NONANE 4 CARBOXYLIC ACID 4 BROMOPHENYL ESTER; BUNGAROTOXIN RECEPTOR; TRACER; UNCLASSIFIED DRUG; [3 (1,4 DIAZABICYCLO[3.2.2]NONAN 4 YL) 6 FLUORODIBENZO[B,D]THIOPHENE 5,5 DIOXIDE] F 18; 3 (1,4 DIAZABICYCLO(3.2.2)NONAN 4 YL) 6 FLUORODIBENZO(B,D)THIOPHENE 5,5 DIOXIDE; 3-(1,4-DIAZABICYCLO(3.2.2)NONAN-4-YL)-6-FLUORODIBENZO(B,D)THIOPHENE 5,5-DIOXIDE; AZABICYCLO DERIVATIVE; DIAGNOSTIC AGENT; NICOTINE; RADIOPHARMACEUTICAL AGENT; SULFOXIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRAIN; CEREBELLUM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISC1 MOUSE; DRUG ACCUMULATION; DRUG BINDING; DRUG METABOLISM; DRUG SELECTIVITY; DRUG STRUCTURE; HEK293 CELL LINE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIPPOCAMPUS; IN VITRO STUDY; IN VIVO STUDY; INSULA; MALE; MOUSE; MOUSE MUTANT; NONHUMAN; PAPIO ANUBIS; PLASMA CONCENTRATION-TIME CURVE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RADIOASSAY; RADIOISOTOPE DISTRIBUTION; RAT; THALAMUS; VOLTAGE CLAMP TECHNIQUE; 18F-ASEM; ANIMAL; BABOON; HUMAN; METABOLISM; METHODOLOGY; PET; SCHIZOPHRENIA; SCINTISCANNING; TISSUE DISTRIBUTION; WESTERN BLOTTING; Α7-NACHR;

18F-ASEM; BABOON; NICOTINE; PET; Α7-NACHR;

ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR; ANIMALS; AZABICYCLO COMPOUNDS; BLOTTING, WESTERN; BRAIN; CYCLIC S-OXIDES; HEK293 CELLS; HUMANS; MALE; MICE; PAPIO; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; SCHIZOPHRENIA; TISSUE DISTRIBUTION;

EID: 84901308400     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.113.132068     Document Type: Article

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