Exercise ameliorates depression-like behavior and increases hippocampal BDNF level in ovariectomized rats

Neuroscience Letters

Volumn 573, Issue , 2014, Pages 13-18

  Lu, Jianqiang ^a   Xu, Yongjun ^b   Hu, Weiwu ^b   Gao, Yuanwu ^a   Ni, Xin ^b   Sheng, Hui ^b   Liu, Yu ^a  

^a SHANGHAI UNIVERSITY OF SPORT   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Brain derived neurotrophic factor; Depression; Estrogen; Exercise; Hippocampus

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; ESTRADIOL; ESTROGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; BINDING AFFINITY; CONTROLLED STUDY; DEPRESSION; ESTROGEN DEFICIENCY; EXERCISE; FEMALE; HIPPOCAMPUS; NONHUMAN; OVARIECTOMY; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; ANIMAL; ESTROGEN THERAPY; METABOLISM; PSYCHOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; DEPRESSION; ESTRADIOL; ESTROGEN REPLACEMENT THERAPY; ESTROGENS; FEMALE; HIPPOCAMPUS; OVARIECTOMY; PHYSICAL CONDITIONING, ANIMAL; PREFRONTAL CORTEX; RATS, SPRAGUE-DAWLEY; RECEPTOR, TRKB;

EID: 84901303007     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2014.04.053     Document Type: Article

References (28)

1. Walf A.A., Frye C.A. A review and update of mechanisms of estrogen in the hippocampus and amygdala for anxiety and depression behavior. Neuropsychopharmacology 2006, 31:1097-1111.
2. Llaneza P., García-Portilla M.P., Llaneza-Suárez D., Armott B., Pérez-López F.R. Depressive disorders and the menopause transition. Maturitas 2012, 71:120-130.
3. Kiss A., Delattre A.M., Pereira S.I., Carolino R.G., Szawka R.E., Anselmo-Franci J.A., Zanata S.M., Ferraz A.C. 17β-estradiol replacement in young, adult and middle-aged female ovariectomized rats promotes improvement of spatial reference memory and an antidepressant effect and alters monoamines and BDNF levels in memory- and depression-related brain areas. Behav. Brain Res. 2012, 227:100-108.
4. Studd J.W. A guide to the treatment of depression in women by estrogens. Climacteric 2011, 14:637-642.
5. Rozenberg S., Vandromme J., Antoine C. Postmenopausal hormone therapy: risks and benefits. Nat. Rev. Endocrinol. 2013, 9:216-227.
6. Dunn A.L., Trivedi M.H., Kampert J.B., Clark C.G., Chambliss H.O. Exercise treatment for depression: efficacy and dose response. Am. J. Prev. Med. 2005, 28:1-8.
7. Zheng H., Liu Y., Li W., Yang B., Chen D., Wang X., Jiang Z., Wang H., Wang Z., Cornelisson G., Halberg F. Beneficial effects of exercise and its molecular mechanisms on depression in rats. Behav. Brain Res. 2006, 168:47-55.
8. Liu W., Sheng H., Xu Y., Liu Y., Lu J., Ni X. Swimming exercise ameliorates depression-like behavior in chronically stressed rats: relevant to proinflammatory cytokines and IDO activation. Behav Brain Res. 2013, 242:110-116.
9. Liu W., Xu Y., Lu J., Zhang Y., Sheng H., Ni X. Swimming exercise ameliorates depression-like behaviors induced by prenatal exposure to glucocorticoids in rats. Neurosci. Lett. 2012, 524:119-123.
10. Stenman E., Lilja A. Increased monoaminergic neurotransmission improves compliance with physical activity recommendations in depressed patients with fatigue. Med. Hypotheses 2013, 80:47-49.
11. Wang J., Chen X., Zhang N., Ma Q. Effects of exercise on stress-induced changes of norepinephrine and serotonin in rat hippocampus. Chin. J. Physiol. 2013, 56:5.
12. Duman R.S., Monteggia L.M. A neurotrophic model for stress-related mood disorders. Biol. Psychiatry 2006, 59:1116-1127.
13. Autry A.E., Monteggia L.M. Brain-derived neurotrophic factor and neuropsychiatric disorders. Pharmacol. Rev. 2012, 64:238-258.
14. Shirayama Y., Chen A.C., Nakagawa S., Russell D.S., Duman R.S. Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression. J. Neurosci. 2002, 22:3251-3261.
15. Steru L., Chermat R., Thierry B., Simon P. The tail suspension test: a new method for screening antidepressants in mice. Psychopharmacology 1985, 85:367-370.
16. O'Leary O.F., Wu X.F., Castren E. Chronic fluoxetine treatment increases expression of synaptic proteins in the hippocampus of the ovariectomized rat: role of BDNF signalling. Psychoneuroendocrinology 2009, 34:367-381.
17. Tanti A., Belzung C. Open questions in current models of antidepressant action. Br. J. Pharmacol. 2010, 159:1187-1200.
18. Singh M., Meyer E.M., Simpkins J.W. The effect of ovariectomy and estradiol replacement on brain-derived neurotrophic factor messenger ribonucleic acid expression in cortical and hippocampal brain regions of female Sprague-Dawley rats. Endocrinology 1995, 136:2320-2324.
19. Li Y., Luikart B.W., Birnbaum S., Chen J., Kwon C.H., Kernie S.G., Bassel-Duby R., Parada L.F. TrkB regulates hippocampal neurogenesis and governs sensitivity to antidepressive treatment. Neuron 2008, 59:399-412.
20. Mukai H., Kimoto T., Hojo Y., Kawato S., Murakami G., Higo S., Murakami G., Komatsuzaki Y., Ogiue-Ikeda M., Kimoto T., Mukai H. Modulation of synaptic plasticity by brain estrogen in the hippocampus. Biochim. Biophys. Acta 2010, 1800:1030-1044.
21. Pfaff D., Keiner M. Atlas of estradiol-concentrating cells in the central nervous system of the female rat. J. Comp. Neurol. 1973, 151:121-158.
22. Diel P. Tissue-specific estrogenic response and molecular mechanisms. Toxicol. Lett. 2002, 127:217-224.
23. Smith C.L., O'Malley B.W. Coregulator function: a key to understanding tissue specificity of selective receptor modulators. Endocr. Rev. 2004, 25:45-71.
24. Westberry J.M., Wilson M.E. Regulation of estrogen receptor alpha gene expression in the mouse prefrontal cortex during early postnatal development. Neurogenetics 2012, 13:159-167.
25. Pighon A., Gutkowska J., Jankowski M., Rabasa-Lhoret R., Lavoie J.M. Exercise training in ovariectomized rats stimulates estrogenic-like effects on expression of genes involved in lipid accumulation and subclinical inflammation in liver. Metabolism 2011, 60:629-639.
26. Meeusen R. Exercise and the brain: insight in new therapeutic modalities. Ann. Transplant. 2005, 10:49-51.
27. Sartori C.R., Vieira A.S., Ferrari E.M., Langone F., Tongiorgi E., Parada C.A. The antidepressive effect of the physical exercise correlates with increased levels of mature BDNF, and proBDNF proteolytic cleavage-related genes, p11 and tPA. Neuroscience 2011, 180:9-18.
28. Wrann C.D., White J.P., Salogiannnis J., Laznik-Bogoslavski D., Wu J., Ma D., Lin J.D., Greenberg M.E., Spiegelman B.M. Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway. Cell Metab. 2013, 18:649-659.