Serum stability and physicochemical characterization of a novel amphipathic peptide C6M1 for siRNA delivery

PLoS ONE

Volumn 9, Issue 5, 2014, Pages

  Jafari, Mousa ^a,b   Xu, Wen ^a,b   Pan, Ran ^a,b   Sweeting, Chad M ^a   Karunaratne, Desiree Nedra ^a,c   Chen, Pu ^a,b  

^a UNIVERSITY OF WATERLOO   (Canada)

^b UNIVERSITY OF WATERLOO   (Canada)

^c UNIVERSITY OF PERADENIYA   (Sri Lanka)

Author keywords

[No Author keywords available]

Indexed keywords

4 (2 HYDROXYETHYL) 1 PIPERAZINEETHANESULFONIC ACID; C6M1 PEPTIDE; DRUG CARRIER; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HEPARIN; PEPTIDE; RIBONUCLEASE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; WATER; CELL PENETRATING PEPTIDE;

ANIMAL CELL; ARTICLE; CELL LEVEL; COMPLEX FORMATION; CONTROLLED STUDY; DRUG CONFORMATION; DRUG DEGRADATION; DRUG STABILITY; DRUG STRUCTURE; FLUORESCENCE SPECTROSCOPY; GENE DELIVERY SYSTEM; GENE SILENCING; LIGHT SCATTERING; NONHUMAN; PARTICLE SIZE; PEPTIDE ANALYSIS; PHYSICAL CHEMISTRY; REACTION TIME; SERUM; WESTERN BLOTTING; ANIMAL; CHEMISTRY; CHO CELL LINE; CRICETULUS; ENZYMOLOGY; GENETIC TRANSFECTION; HAMSTER; METABOLISM; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; RNA STABILITY;

ANIMALS; CELL-PENETRATING PEPTIDES; CHO CELLS; CRICETINAE; CRICETULUS; GENE KNOCKDOWN TECHNIQUES; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASES; PROTEIN STABILITY; PROTEIN STRUCTURE, SECONDARY; RIBONUCLEASES; RNA STABILITY; RNA, SMALL INTERFERING; SERUM; TRANSFECTION;

EID: 84901302499     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0097797     Document Type: Article

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