Maternal separation enhances conditioned fear and decreases the mRNA levels of the neurotensin receptor 1 gene with hypermethylation of this gene in the rat amygdala

PLoS ONE

Volumn 9, Issue 5, 2014, Pages

  Toda, Hiroyuki ^a,b   Boku, Shuken ^c   Nakagawa, Shin ^b   Inoue, Takeshi ^b   Kato, Akiko ^b   Takamura, Naoki ^d   Song, Ning ^b,e   Nibuya, Masashi ^a   Koyama, Tsukasa ^b   Kusumi, Ichiro ^b  

^a NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

^b HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

^e CHINA MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; NEUROTENSIN; CORTICOTROPIN RELEASING FACTOR; DEXAMETHASONE; NEUROTENSIN RECEPTOR; NEUROTENSIN TYPE 1 RECEPTOR;

ADULT; AMYGDALOID NUCLEUS; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANXIETY; ARTICLE; CONTROLLED STUDY; DNA METHYLATION; EPIGENETICS; FEAR; GENE; GENE EXPRESSION; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MALE; MATERNAL DEPRIVATION; NEUROTENSIN RECEPTOR 1 GENE; NONHUMAN; PROMOTER REGION; RAT; ANIMAL; CHEMISTRY; CONDITIONED REFLEX; GENETIC EPIGENESIS; GENETICS; HIPPOCAMPUS; HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS SYSTEM; MAZE TEST; MEMORY; METABOLISM; MOLECULAR GENETICS; MOTHER; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

AMYGDALA; ANIMALS; ANXIETY; BASE SEQUENCE; CONDITIONING, CLASSICAL; CORTICOTROPIN-RELEASING HORMONE; DEXAMETHASONE; DNA METHYLATION; EPIGENESIS, GENETIC; FEAR; HIPPOCAMPUS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MALE; MAZE LEARNING; MEMORY; MOLECULAR SEQUENCE DATA; MOTHERS; NEUROTENSIN; PITUITARY-ADRENAL SYSTEM; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NEUROTENSIN; RNA, MESSENGER;

EID: 84901299295     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0097421     Document Type: Article

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