Design, statistical optimisation, characterisation and pharmacodynamic studies on Pioglitazone hydrochloride floating microparticles

Journal of Microencapsulation

Volumn 31, Issue 4, 2014, Pages 406-414

  Rao, B Prakash ^a   Baby, Beny ^a   Mathews, Rashmi ^a   Rajarajan, S ^a   Haritha, Puri ^a   Ramesh, K ^a   Gupta, N Vijay Kumar ^a  

^a KARNATAKA COLLEGE OF PHARMACY   (India)

Author keywords

Eudragit RS 100; Factorial design; Pharmacodynamics; Pioglitazone floating microparticles; RL 100

Indexed keywords

EUDRAGIT; EUDRAGIT RS; EXCIPIENT; GLUCOSE; PIOGLITAZONE; 2,4 THIAZOLIDINEDIONE DERIVATIVE; ANTIDIABETIC AGENT; DELAYED RELEASE FORMULATION; DRUG CARRIER; GLUCOSE BLOOD LEVEL;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DESIGN; DRUG MANUFACTURE; DRUG RELEASE; EVAPORATION; FACTORIAL DESIGN; FEASIBILITY STUDY; FLOATING MICROPARTICLE; FOURIER TRANSFORM INFRARED PHOTOACOUSTIC SPECTROSCOPY; GLUCOSE BLOOD LEVEL; IN VITRO STUDY; NEW ZEALAND WHITE (RABBIT); NONHUMAN; PARTICLE SIZE; PHARMACODYNAMICS; SCANNING ELECTRON MICROSCOPE; SCANNING ELECTRON MICROSCOPY; TIME TO MAXIMUM PLASMA CONCENTRATION; X RAY DIFFRACTION; ANIMAL; CHEMISTRY; DELAYED RELEASE FORMULATION; DRUG SCREENING; MALE; METABOLISM; PHARMACOKINETICS; PHARMACOLOGY; RABBIT;

ANIMALS; BLOOD GLUCOSE; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; DRUG EVALUATION, PRECLINICAL; HYPOGLYCEMIC AGENTS; MALE; RABBITS; THIAZOLIDINEDIONES;

EID: 84901291544     PISSN: 02652048     EISSN: 14645246     Source Type: Journal    
DOI: 10.3109/02652048.2013.863399     Document Type: Article

References (16)

1. Adukondalu D, Malathy PS, Venkateshwar Rao J, Madhusudan Rao Y. Development and validatiion of HPLC method for detection of PGHCl in dosage forms. Int J Pharm Bio Sci, 2011;1(4):474-8.
2. Brahmankar DM, Jaiswal SB. 2001. Biopharmaceutics and pharmaco-kinetics a treatise, 1st edn. Delhi: Vallabh Prakashan Pitampura, pp. 337-41.
3. Chien YW. Rate-controlled drug delivery systems. Ind J Pharm Sci, 1988; Mar-Apr:63-5.
4. Deepa K, Karthikeyan M, Ramasamy C. Development of floating microspheres to improve oral bioavailability of cefpodoxime proxetil. Acta Pharm Sci, 2010;52:101-4.
5. Dehghan S, Aboofazeli R, Avadi M, Khaksar R. Formulation optimization of nifedipine containing microspheres using factorial design. Afri J Pharm Pharmacol, 2010;4(6):346-54.
6. Dhakar RC, Maurya SD, Aggarwal S, Kumar G, Tilak VK. Design and evaluation of SRM microspheres of metformin hydrochloride. Int J Comp Pharm, 2010;1:1-5.
7. Gattani YS, Kawtikwar PS, Sakarkar DM. Formulation and evaluation of gastro retentive multiparticulate drug delivery system of aceclofenac. Int J Chem Tech Res, 2009;1(1):1-10.
8. Hosmani AH, Kasture PV. Preparation and in vitro and in vivo evaluation of glipizide mucoadhesive microspheres using factorial design. Lat Am J Pharm, 2009;28(2):254-60.
9. Kalyankar TM, Rangari NT, Khan M, Hosmani A, Sonwane A. Formulation and evaluation of mucoadhesive pioglitazone HCl micro-spheres. Int J Pharma World Res, 2010;1(3):1-14.
10. Kannan K, Karar PK, Manavalan R. Formulation and evaluation of sustained release microspheres of acetazolamide by solvent evaporation technique. J Pharm Sci Res, 2009;1(1):36-9.
11. Kawashima Y, Takeuchi H, Yamamoto H. 2005. A gastro intestinal microparticulate system to improve oral drug delivery. In: Wise DL, ed. Handbook of pharmaceutical controlled release technology. New York: Marcel Dekker Inc., Raven Press, pp. 505-25.
12. Mastiholimath VS, Dandagi PM, Gadad AP, Mathews R, Kulkarni AR. In vitro and in vivo evaluation of ranitidine hydrochloride ethyl cellulose floating microparticles. J Microencapsul, 2008;25(5):307-14.
13. Pachuau L, Sankar S, Mazumder B. Formulation evaluation of matrix microspheres for simultaneous delivery of salbutamol sulphate and theophylline. Trop J Pharm Res, 2008;7(2):995-1002.
14. Phalguna Y, Venkateshwarlu BS, Gudas GK, Debnath S. HPMC microspheres of zidovudine for sustained release. Int J Pharm Pharm Sci, 2010;2(Suppl. 4):41-3.
15. Punitha K, Khadhir S, Ravichandiran V, Umadevi SK, Vaijayanthi V, Padmapriya S, Suresh Kumar S. Intragastric floating drug delivery system of ranitidine hydrochloride: Formulation and evaluation. Int J Pharm Pharm Sci, 2010;2(4):105-8.
16. Sheth Z, Mudgal S, Singh M, Gupta M. Design and development of 5-fluorouracil loaded biodegradable microspheres. Int J Res Ayurveda Pharm, 2010;1(1):160-8.