Intragastric floating drug delivery system of ranitidine hydrochloride: Formulation and evaluation

International Journal of Pharmacy and Pharmaceutical Sciences

Volumn 2, Issue 4, 2010, Pages 105-108

  Punitha, K ^a   Khadhir, S ^a   Ravichandiran, V ^a   Umadevi, S K ^a   Vaijayanthi, V ^a   Padmapriya, S ^a   Suresh Kumar, S ^a  

^a VELS INSTITUTE OF SCIENCE   (India)

Author keywords

Dissolution and kinetics; Eudragit E 100; Floating microspheres; HPMC 15 cps; Ranitidine Hcl; SEM

Indexed keywords

EUDRAGIT; MICROSPHERE; POLYMER; RANITIDINE;

ARTICLE; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RETENTION; DRUG SCREENING; DRUG SOLUBILITY; INTESTINE ABSORPTION; PARTICLE SIZE; UPPER GASTROINTESTINAL TRACT;

EID: 79959839987     PISSN: None     EISSN: 09751491     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Fix JA, Cargill R, Engle K. Controlled gastric emptying. III. Gastric residence time of a non-disintegrating geometric shape in human volunteers. Pharm Res. 1993; 10: 1087-1089.
2. Groning R, Heun G. Oral dosage forms with controlled gastrointestinal transit. Drug Dev Ind Pharm. 1984; 10: 527-539.
3. Vantrappen GR, Peeters TL, Janssens J. The secretory component of interdigestive migratory motor complex in man. Scand J Gastroenterol. 1979; 14: 663-667.
4. Desai S, Bolton S. A floating controlled release drug delivery system: in vitro- in vivo evaluation. Pharm Res. 1993; 10: 1321-1325.
5. Arora S, Ali J, Ahuja A, Khar R K, Baboota S, 2005; Floating Drug Delivery Systems: A review. AAPS Pharm Sci Tech. 06(03); 372-390.
6. Stanley S. Davis, Formulation strategies for absorption windows. Drug Discovery Today, 2005; (10), 249-257.
7. Sunil K. Jain, A.M. Awasti, N.K. Jain, G.P. Agarwal, Gastroretentive floating drug delivery. An overview. Drug Del. Tech. 5(7): 176-187.
8. Yang L, Fassihi R. Zero order release kinetics from self correcting floatable configuration drug delivery system. J Pharm Sci. 1996; 85: 170-173.
9. Joseph NJ, Laxmi S, Jayakrishnan A. A floating type oral dosage form for piroxicam based on hollow microspheres: in vitro and in vivo evaluation in rabbits. J Control Release. 2002; 79: 71-79.
10. Sheth PR, Tossounian JL. Sustained release pharmaceutical capsules. US patent 4,126,672. November 21, 1978.
11. Yang L, Fassihi R. Zero order release kinetics from self correcting floatable configuration drug delivery system. J Pharm Sci. 1996; 85: 170-173.
12. Soppimath KS, Kulkarni AR, Rudzinski WE, Aminabhavi TM. Microspheres as floating drug delivery system to increase the gastric residence of drugs. Drug Metab Rev. 2001; 33: 149-160.
13. Ichikawa M, Watanabe S, Miyake Y. A new multiple unit oralfloating dosage system. I: Prepration and in vitro evaluation of floating and sustained-release kinetics. J Pharm Sci. 1991; 80: 1062-1066.
14. V. S. Mastiholimath, P. M. Dandagi, A. P. Gadad, Rashmi mathews, & a. R. Kulkarni. In vitro and in vivo evaluation of ranitidine hydrochloride ethyl cellulose floating microparticles. Journal of Microencapsulation. 2008; 25(5): 307-314.
15. Hui Yun Zhou, Xi Guang Chen, Cheng Sheng Liu, Xiang Hong Meng, Chen Guang Liu, Jun He, and Le Jun Yu. Cellulose Acetate/Chitosan Multimicrospheres Preparation and Ranitidine Hydrochloride Release in Vitro. Drug Delivery, 2006; 13: 261-267.
16. Yu-meng Wei and Ling Zhao. In Vitro and In Vivo Evaluation of Ranitidine Hydrochloride Loaded Hollow Microspheres in Rabbits. Arch Pharm Res. 2008; Vol 31, No 10, 1369-1377.
17. R Garg, GD Gupta. Progress in Controlled Gastroretentive Delivery Systems. Tropical Journal of Pharmaceutical Research, September 2008; 7 (3): 1055-1066.
18. Ferreira, M.O., Bahia, M.F., Costa, P. Stability of ranitidine hydrochloride in different aqueous solutions. EJHP, 2004; 4: 60-63.
19. J M Patil, R S Hirlekar, P S Gide and V J Kadam. Trends in floating drug delivery systems. Journal of Scientific and Industrial Research, 2006; VOL. 65: pp. 11-21.
20. J. Varshosaz, M. Tabbakhian, and M. Zahrooni. Development and characterization of floating microballoons for oral delivery of cinnarizine by a factorial design. Journal of Microencapsulation, 2007; 24(3): 253-262.