Label-free in situ monitoring of histone deacetylase drug target engagement by matrix-assisted laser desorption ionization-mass spectrometry biotyping and imaging

Analytical Chemistry

Volumn 86, Issue 10, 2014, Pages 4642-4647

  Munteanu, Bogdan ^a,b   Meyer, Björn ^a,b   Von Reitzenstein, Carolina ^a,b   Burgermeister, Elke ^a   Bog, Susanne ^c   Pahl, Andreas ^c   Ebert, Matthias P ^a   Hopf, Carsten ^a,b  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b MANNHEIM UNIVERSITY OF APPLIED SCIENCES   (Germany)

^c Wilex Biotechnology GmbH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLATION; DRUG PRODUCTS; ENZYME INHIBITION; IONIZATION; PROTEINS; TUMORS;

HISTONE DEACETYLASE INHIBITOR; HISTONE DEACETYLASES; IN- SITU MONITORING; MALDI-MASS SPECTROMETRY; MATRIX-ASSISTED LASER DESORPTION IONIZATION; MATRIX-ASSISTED LASER DESORPTION IONIZATION MASS SPECTROMETRY; PHARMACODYNAMIC RESPONSE; SPATIOTEMPORAL DISTRIBUTIONS;

MASS SPECTROMETRY;

HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR;

ANIMAL; CELLS; DRUG DEVELOPMENT; DRUG EFFECTS; ENZYMOLOGY; GASTROINTESTINAL NEOPLASMS; MASS SPECTROMETRY; MOUSE; PROCEDURES;

ANIMALS; CELLS; DRUG DISCOVERY; GASTROINTESTINAL NEOPLASMS; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; MICE; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 84901273491     PISSN: 00032700     EISSN: 15206882     Source Type: Journal    
DOI: 10.1021/ac500038j     Document Type: Article

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