Cell migration leads to spatially distinct but clonally related airway cancer precursors

Thorax

Volumn 69, Issue 6, 2014, Pages 548-557

  Pipinikas, Christodoulos P ^a   Kiropoulos, Theodoros S ^a,b   Teixeira, Vitor H ^a   Brown, James M ^a   Varanou, Aikaterini ^a   Falzon, Mary ^a   Capitanio, Arrigo ^a   Bottoms, Steven E ^a   Carrol, Bernadette ^c   Navani, Neal ^a,c   McCaughan, Frank ^d,e   George, Jeremy P ^c   Giangreco, Adam ^a   Wright, Nicholas A ^f,g   McDonald, Stuart A C ^f,g   Graham, Trevor A ^f,h   Janes, Sam M ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF THESSALY   (Greece)

^c UNIVERSITY COLLEGE LONDON HOSPITALS   (United Kingdom)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^e KING'S COLLEGE LONDON   (United Kingdom)

^f IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^g QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^h UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; AUTOFLUORESCENCE; BRONCHOSCOPY; CANCER STAGING; CARCINOMA IN SITU; CELL EXPANSION; CELL MIGRATION; CLINICAL ARTICLE; CLONAL VARIATION; CONTROLLED STUDY; EPITHELIUM CELL; GENE DELETION; GENE SEQUENCE; HETEROZYGOSITY LOSS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LUNG BIOPSY; MALE; MIDDLE AGED; MOLECULAR MODEL; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; TRACHEA CARCINOMA; TRACHEOBRONCHIAL TREE; TUMOR SUPPRESSOR GENE;

AIRWAY EPITHELIUM; LUNG CANCER;

ADULT; CARCINOMA IN SITU; CARCINOMA, SQUAMOUS CELL; CELL MOVEMENT; GENES, P53; HUMANS; LOSS OF HETEROZYGOSITY; LUNG NEOPLASMS; MALE; MIDDLE AGED; MUTATION; NEOPLASM INVASIVENESS; PRECANCEROUS CONDITIONS; TRACHEAL NEOPLASMS;

EID: 84901245830     PISSN: 00406376     EISSN: 14683296     Source Type: Journal    
DOI: 10.1136/thoraxjnl-2013-204198     Document Type: Article

References (29)

1. Auerbach O, Stout AP, Hammond EC, et al. Changes in bronchial epithelium in relation to cigarette smoking and in relation to lung cancer. N Engl J Med 1961;265:253-67.
2. George PJ, Banerjee AK, Read CA, et al. Surveillance for the detection of early lung cancer in patients with bronchial dysplasia. Thorax 2007;62:43-50. (Pubitemid 46101765)
3. Pairolero PC, Williams DE, Bergstralh EJ, et al. Postsurgical stage I bronchogenic carcinoma: morbid implications of recurrent disease. Ann Thorac Surg 1984;38:331-8. (Pubitemid 14012545)
4. Rubin H. Fields and field cancerization: the preneoplastic origins of cancer: asymptomatic hyperplastic fields are precursors of neoplasia, and their progression to tumors can be tracked by saturation density in culture. Bioessays 2011;33:224-31.
5. Graham TA, McDonald SA, Wright NA. Field cancerization in the GI tract. Future Oncol 2011;7:981-93.
6. Sidransky D, Frost P, Von Eschenbach A, et al. Clonal origin of bladder cancer. N Engl J Med 1992;326:737-40.
7. Leedham SJ, Graham TA, Oukrif D, et al. Clonality, founder mutations, and field cancerization in human ulcerative colitis-associated neoplasia. Gastroenterology 2009;136:542-50.e6.
8. Zhang W, Hanks AN, Boucher K, et al. UVB-induced apoptosis drives clonal expansion during tumor development. Carcinogenesis 2005;26:249-57. (Pubitemid 40207720)
9. Försti A, Louhelainen J, Söderberg M, et al. Loss of heterozygosity in tumour-adjacent normal tissue of breast and bladder cancer. Eur J Cancer 2001;37:1372-80. (Pubitemid 32588748)
10. McDonald SAC, Greaves LC, Gutierrez-Gonzalez L, et al. Mechanisms of field cancerization in the human stomach: the expansion and spread of mutated gastric stem cells. Gastroenterology 2008;134:500-10. (Pubitemid 351173048)
11. Maley CC, Galipeau PC, Li X, et al. Selectively advantageous mutations and hitchhikers in neoplasms: p16 lesions are selected in Barrett's esophagus. Cancer Res 2004;64:3414-27. (Pubitemid 38657913)
12. Mehra R, Tomlins SA, Yu J, et al. Characterization of TMPRSS2-ETS gene aberrations in androgen-independent metastatic prostate cancer. Cancer Res 2008;68:3584-90.
13. Slaughter PD, Southwick HW, Smejkal W. "Field Cancerization" in oral stratified squamous epithelium: Clinical implications of multicentric origin. Cancer 1953;6:963-8.
14. Braakhuis BJM, Tabor MP, Kummer JA, et al. A Genetic explanation of Slaughter's concept of field cancerization: evidence and clinical implications. Cancer Res 2003;63:1727-30. (Pubitemid 36460827)
15. Franklin WA, Gazdar AF, Haney J, et al. Widely dispersed p53 mutation in respiratory epithelium. A novel mechanism for field carcinogenesis. J Clin Invest 1997;100:2133-7. (Pubitemid 27459370)
16. Sundaresan V, Ganly P, Hasleton P, et al. p53 and chromosome 3 abnormalities, characteristic of malignant lung tumours, are detectable in preinvasive lesions of the bronchus. Oncogene 1992;7:1989-97.
17. Hung J, Kishimoto Y, Sugio K, et al. Allele-specific chromosome 3p deletions occur at an early stage in the pathogenesis of lung carcinoma. JAMA 1995;273:558-63.
18. Wistuba II, Behrens C, Milchgrub S, et al. Sequential molecular abnormalities are involved in the multistage development of squamous cell lung carcinoma. Oncogene 1999;18:643-50. (Pubitemid 29080321)
19. Lam S, Kennedy T, Unger M, et al. Localization of bronchial intraepithelial neoplastic lesions by fluorescence bronchoscopy. Chest 1998;113:696-702. (Pubitemid 28130944)
20. Banerjee AK, Rabbitts PH, George JP. Preinvasive bronchial lesions: surveillance or intervention? Chest 2004;125:95S-6S. (Pubitemid 38648322)
21. McCaughan F, Pipinikas CP, Janes SM, et al. Genomic evidence of preinvasive clonal expansion, dispersal and progression in bronchial dysplasia. J Pathol 2011;224:153-9.
22. Steiling K, Ryan J, Brody JS, et al. The field of tissue injury in the lung and airway. Cancer Prev Res (Phila) 2008;1:396-403.
23. Tabor MP, Brakenhoff RH, Ruijter-Schippers HJ, et al. Multiple head and neck tumors frequently originate from a single preneoplastic lesion. Am J Pathol 2002;161:1051-60. (Pubitemid 34988393)
24. Simon R, Eltze E, Schäfer KL, et al. Cytogenetic analysis of multifocal bladder cancer supports a monoclonal origin and intraepithelial spread of tumor cells. Cancer Res 2001;61:355-62. (Pubitemid 32095738)
25. Prevo LJ, Sanchez CA, Galipeau PC, et al. p53-mutant clones and field effects in Barrett's esophagus. Cancer Res 1999;59:4784-7. (Pubitemid 29472876)
26. Petitjean A, Mathe E, Kato S, et al. Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database. Hum Mut 2007;28:622-9. (Pubitemid 46744292)
27. Forbes SA, Bhamra G, Bamford S, et al. The Catalogue of Somatic Mutations in Cancer (COSMIC). Curr Protoc Hum Genet 2008;Chapter 10:Unit 10.11.
28. Rock JR, Onaitis MW, Rawlins EL, et al. Basal cells as stem cells of the mouse trachea and human airway epithelium. Proc Natl Acad Sci USA 2009;106:12771-5.
29. Teixeira VH, Nadarajan P, Graham TA, et al. Stochastic homeostasis in human airway epithelium is achieved by neutral competition of basal cell progenitors. eLife 2013;2:e00966.