A one-year follow-up analysis of antidepressants in Portuguese wastewaters: Occurrence and fate, seasonal influence, and risk assessment

Science of the Total Environment

Volumn 490, Issue , 2014, Pages 279-287

  Silva, Liliana J G ^a   Pereira, André M P T ^a   Meisel, Leonor M ^b,c   Lino, Celeste M ^a   Pena, Angelina ^a  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b INFARMED)   (Portugal)

^c RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

Author keywords

Environmental contaminants; Environmental risk; Municipal wastewaters; Occurrence and fate; Seasonal influence; Selective serotonin re uptake inhibitors

Indexed keywords

LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY;

ENVIRONMENTAL CONTAMINANT; ENVIRONMENTAL RISKS; MUNICIPAL WASTEWATERS; OCCURRENCE AND FATE; SEASONAL INFLUENCE; SELECTIVE SEROTONIN RE-UPTAKE INHIBITORS;

RISK ASSESSMENT;

ANTIDEPRESSANT AGENT; CITALOPRAM; FLUOXETINE; PAROXETINE; SERTRALINE; WASTE WATER; WATER POLLUTANT;

DRUG; EFFLUENT; ENVIRONMENTAL FATE; INHIBITOR; LIQUID CHROMATOGRAPHY; RISK ASSESSMENT; SAMPLING; WASTEWATER;

ALGA; AQUATIC SPECIES; ARTICLE; AUTUMN; DAPHNIA; DRUG USE; ECOTOXICOLOGY; EFFLUENT; ENVIRONMENTAL EXPOSURE; FISH; FOLLOW UP; LIQUID CHROMATOGRAPHY; NONHUMAN; PORTUGAL; PRESCRIPTION; PRIORITY JOURNAL; RISK ASSESSMENT; SEASONAL VARIATION; SPRING; SUMMER; TANDEM MASS SPECTROMETRY; WASTE COMPONENT REMOVAL; WASTE WATER; WASTE WATER TREATMENT PLANT; WATER CONTAMINATION; WATER SAMPLING; WINTER; ANALYSIS; CHEMISTRY; ENVIRONMENTAL MONITORING; SEASON; SEWAGE; STATISTICS AND NUMERICAL DATA; WATER POLLUTANT;

PORTUGAL;

ANTIDEPRESSIVE AGENTS; ENVIRONMENTAL MONITORING; FOLLOW-UP STUDIES; PORTUGAL; RISK ASSESSMENT; SEASONS; WASTE DISPOSAL, FLUID; WASTE WATER; WATER POLLUTANTS, CHEMICAL;

EID: 84901243760     PISSN: 00489697     EISSN: 18791026     Source Type: Journal    
DOI: 10.1016/j.scitotenv.2014.04.131     Document Type: Article

References (52)

1. Azzouz A., Ballesteros E. Influence of seasonal climate differences on the pharmaceutical, hormone and personal care product removal efficiency of a drinking water treatment plant. Chemosphere 2013, 93(9):2046-2054. [Internet, Elsevier Ltd; Aug 10 [cited 2013 Oct 23]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/23942020].
2. Batt A.L., Kostich M.S., Lazorchak J.M. Analysis of ecologically relevant pharmaceuticals in wastewater and surface water using selective solid-phase extraction and UPLC-MS/MS. Anal Chem 2008, 80(13):5021-5030. [Internet, Jul 1, Available from: http://www.ncbi.nlm.nih.gov/pubmed/18498179].
3. Brooks B.W., Kevin Chambliss C., Stanley J.K., Ramirez A., Banks K.E., Johnson R.D., et al. Determination of select antidepressants in fish from an effluent-dominated stream. Environ Toxicol Chem 2005, 24(2):464-469. [Internet, cited 2013 Oct 23, Available from: http://doi.wiley.com/10.1897/04-081R.1].
4. Chu S., Metcalfe C.D. Analysis of paroxetine, fluoxetine and norfluoxetine in fish tissues using pressurized liquid extraction, mixed mode solid phase extraction cleanup and liquid chromatography-tandem mass spectrometry. J Chromatogr A 2007, 1163(1-2):112-118. [Internet, Sep 7 [cited 2013 Oct 23; Available from: http://www.ncbi.nlm.nih.gov/pubmed/17603064].
5. Cunningham V.L., Constable D.J.C., Hannah R.E. Environmental risk assessment of paroxetine. Environ Sci Technol 2004, 38(12):3351-3359. [Internet, Jun 15Available from: http://www.ncbi.nlm.nih.gov/pubmed/15260335].
6. Demeestere K., Petrović M., Gros M., Dewulf J., Van Langenhove H., Barceló D. Trace analysis of antidepressants in environmental waters by molecularly imprinted polymer-based solid-phase extraction followed by ultra-performance liquid chromatography coupled to triple quadrupole mass spectrometry. Anal Bioanal Chem 2010, 396(2):825-837. [Internet, Jan [cited 2013 Oct 23; Available from: http://www.ncbi.nlm.nih.gov/pubmed/19924405].
7. Emea Guideline on the environmental risk assessment of medicinal products for human use 2006, 1-12. London.
8. Environmental Classified Pharmaceuticals Environmental classified pharmaceuticals 2008, 1-32. Stockholm.
9. Eurobarometer Mental health part 1: Report directorate general health and consumers survey co-ordinated by directorate general, communication 2010, 1-64.
10. Fick J., Soderstrom H., Lindberg R.H., Phan C., Tysklind M., Joakim Ldg. Contamination of surface, ground, and drinking water from pharmaceutical production. Environ Toxicol Chem 2009, 28(12):2522-2527.
11. González Alonso S., Catalá M., Maroto R.R., Gil J.L.R., de Miguel A.G., Valcárcel Y. Pollution by psychoactive pharmaceuticals in the Rivers of Madrid metropolitan area (Spain). Environ Int 2010, 36(2):195-201. [Internet, Elsevier Ltd; Feb [cited 2013 Oct 23]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/20022376].
12. Gracia-Lor E., Sancho J.V., Serrano R., Hernández F. Occurrence and removal of pharmaceuticals in wastewater treatment plants at the Spanish Mediterranean area of Valencia. Chemosphere 2012, 87(5):453-462. [Internet, Elsevier Ltd; Apr [cited 2013 Oct 23]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/22221664].
13. Gros M., Petrović M., Barceló D. Tracing pharmaceutical residues of different therapeutic classes in environmental waters by using liquid chromatography/quadrupole-linear ion trap mass spectrometry and automated library searching. Anal Chem 2009, 81(3):898-912. [[Internet, Feb 1 Available from: http://www.ncbi.nlm.nih.gov/pubmed/19113952].
14. Gros M., Petrović M., Ginebreda A., Barceló D. Removal of pharmaceuticals during wastewater treatment and environmental risk assessment using hazard indexes. Environ Int 2010, 36(1):15-26. [Internet, Jan [cited 2013 Oct 23]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/19819553].
15. Gros M., Rodríguez-Mozaz S., Barceló D. Fast and comprehensive multi-residue analysis of a broad range of human and veterinary pharmaceuticals and some of their metabolites in surface and treated waters by ultra-high-performance liquid chromatography coupled to quadrupole-linear ion trap tandem. J Chromatogr A 2012, 1248:104-121. [Internet, Elsevier B.V.; Jul 27 [cited 2013 Oct 23]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/22704668].
16. Henry T.B., Black M.C. Mixture and single-substance acute toxicity of selective serotonin reuptake inhibitors in Ceriodaphnia dubia. Environ Toxicol Chem 2007, 26(8):1751-1755. [Internet, Aug; Available from: http://www.ncbi.nlm.nih.gov/pubmed/17702351].
17. Henry T.B., Kwon J.-W., Armbrust K.L., Black M.C. Acute and chronic toxicity of five selective serotonin reuptake inhibitors in Ceriodaphnia dubia. Environ Toxicol Chem 2004, 23(9):2229-2233. [Internet, Sep. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15379001].
18. Himmelsbach M., Buchberger W., Klampfl C.W. Determination of antidepressants in surface and waste water samples by capillary electrophoresis with electrospray ionization mass spectrometric detection after preconcentration using off-line solid-phase extraction. Electrophoresis 2006, 27(5-6):1220-1226. [Internet, Mar [cited 2014 Feb 20]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/16440399].
19. Infarmed Medicines statistic 2011 2011.
20. Jelic A., Gros M., Ginebreda A., Cespedes-Sánchez R., Ventura F., Petrovic M., et al. Occurrence, partition and removal of pharmaceuticals in sewage water and sludge during wastewater treatment. Water Res 2011, 45(3):1165-1176. [Internet, Jan [cited 2013 Oct 23]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/21167546].
21. Kasprzyk-Hordern B., Dinsdale R.M., Guwy A.J. Illicit drugs and pharmaceuticals in the environment-forensic applications of environmental data, Part 2: pharmaceuticals as chemical markers of faecal water contamination. Environ Pollut 2009, 157(6):1778-1786. [Internet, Elsevier Ltd; Jun [cited 2013 Oct 23]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/19299056].
22. Kolpin D.W., Furlong E.T., Meyer M.T., Thurman E.M., Zaugg S.D., Barber L.B., et al. Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S. streams, 1999-2000: a national reconnaissance. Environ Sci Technol 2002, 36(6):1202-1211. [Internet, Mar 15, Available from: http://www.ncbi.nlm.nih.gov/pubmed/11944670].
23. Kurlansik S.L., Ibay A.D. Seasonal affective disorder. Am Fam Physician 2012, 86:1037-1041.
24. Lajeunesse A., Gagnon C., Sauvé S. Determination of basic antidepressants and their N-desmethyl metabolites in raw sewage and wastewater using solid-phase extraction and liquid chromatography-tandem mass spectrometry. Anal Chem 2008, 80(14):5325-5333. [Internet, Jul 15, Available from: http://www.ncbi.nlm.nih.gov/pubmed/18553982].
25. Lajeunesse A., Smyth S.A., Barclay K., Sauvé S., Gagnon C. Distribution of antidepressant residues in wastewater and biosolids following different treatment processes by municipal wastewater treatment plants in Canada. Water Res 2012, 46(17):5600-5612. [Internet, Nov 1 [cited 2013 Oct 23]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/22898669].
26. Loos R., Carvalho R., Comero S., António D.C., Ghiani M., Lettieri T., et al. EU Wide Monitoring Survey on Waste Water Treatment Plant Effluents (Report EUR 25563) 2012, 1-138.
27. MacLeod S.L., Sudhir P., Wong C.S. Stereoisomer analysis of wastewater-derived beta-blockers, selective serotonin re-uptake inhibitors, and salbutamol by high-performance liquid chromatography-tandem mass spectrometry. J Chromatogr A 2007, 1170(1-2):23-33. [Internet, Nov 2 [cited 2013 Oct 23]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/17915230].
28. Metcalfe C.D., Miao X.-S., Koenig B.G., Struger J. Distribution of acidic and neutral drugs in surface waters near sewage treatment plants in the lower Great Lakes, Canada. Environ Toxicol Chem 2003, 22(12):2881-2889. [Internet, Dec Available from: http://www.ncbi.nlm.nih.gov/pubmed/14713027].
29. Metcalfe C.D., Chu S., Judt C., Li H., Oakes K.D., Servos M.R., et al. Antidepressants and their metabolites in municipal wastewater, and downstream exposure in an urban watershed. Environ Toxicol Chem 2010, 29(1):79-89. [Internet, 2010 Jan [cited 2013 Oct 23]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/20821422].
30. Mompelat S., Le Bot B., Thomas O. Occurrence and fate of pharmaceutical products and by-products, from resource to drinking water. Environ Int 2009, 35(5):803-814. [Internet, Elsevier Ltd;Jul [cited 2013 Oct 21]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/19101037].
31. Nagarnaik P., Batt A., Boulanger B. Source characterization of nervous system active pharmaceutical ingredients in healthcare facility wastewaters. J Environ Manage 2011, 92(3):872-877. [Internet, Elsevier Ltd; 2011 Mar [cited 2013 Oct 23]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/21094579].
32. Petrovic M., Ginebreda A., Acuña V., Batalla R.J., Elosegi A., Guasch H., et al. Combined scenarios of chemical and ecological quality under water scarcity in Mediterranean rivers. TrAC Trends Anal Chem 2011, 30(8):1269-1278. [Internet, Sep [cited 2013 Oct 23].
33. Portuguese National Health Plan Consumption of anxiolytic, soporific, sedative and antidepressants in the NHS market, in the out-patient service [Internet] 2009, [Available from: http://impns.dgs.pt/en/access-to-medicines/consumption-of-anxiolytic-soporific-sedative-and-antidepressants-in-the-nhs-market-in-the-out-patient-service].
34. Ramirez A.J., Mottaleb M.A., Brooks B.W., Chambliss C.K. Analysis of pharmaceuticals in fish using liquid chromatography-tandem mass spectrometry. Anal Chem 2007, 79(8):3155-3163. [Internet, Apr 15, Available from: http://www.ncbi.nlm.nih.gov/pubmed/17348635].
35. Richards S.M., Cole S.E. A toxicity and hazard assessment of fourteen pharmaceuticals to Xenopus laevis larvae. Ecotoxicology 2006, 15(8):647-656. [Internet, Nov [cited 2013 Nov 5]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/17077997].
36. Salgado R., Noronha J.P., Oehmen A., Carvalho G., Reis M.A.M. Analysis of 65 pharmaceuticals and personal care products in 5 wastewater treatment plants in Portugal using a simplified analytical methodology. Water Sci Technol 2010, 62(12):2862-2871. [Internet, Jan [cited 2013 Oct 23]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/21123916].
37. Salgado R., Marques R., Noronha J.P., Mexia J.T., Carvalho G., Oehmen A., et al. Assessing the diurnal variability of pharmaceutical and personal care products in a full-scale activated sludge plant. Environ Pollut 2011, 159(10):2359-2367. [Internet, Elsevier Ltd; Oct [cited 2013 Oct 23]; Available from: http://linkinghub.elsevier.com/retrieve/pii/S0269749111003745].
38. Santos L.H.M.L.M., Araújo N., Fachini A., Pena A., Delerue-Matos C., Montenegro M.C.B.S.M. Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment. J Hazard Mater 2010, 175(1-3):45-95. [Internet, Mar 15 [cited 2013 Oct 23]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/19954887].
39. Santos L.H.M.L.M., Gros M., Rodriguez-Mozaz S., Delerue-Matos C., Pena A., Barceló D., et al. Contribution of hospital effluents to the load of pharmaceuticals in urban wastewaters: identification of ecologically relevant pharmaceuticals. Sci Total Environ 2013, 461-462:302-316. [Internet, Elsevier B.V.; Sep 1 [cited 2013 Oct 17]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/23732224].
40. Schultz M.M., Furlong E.T. Trace analysis of antidepressant pharmaceuticals and their select degradates in aquatic matrixes by LC/ESI/MS/MS. Anal Chem 2008, 80(5):1756-1762. [Internet, Mar 1Available from: http://www.ncbi.nlm.nih.gov/pubmed/18229944].
41. Schultz M.M., Furlong E.T., Kolpin D.W., Werner S.L., Schoenfuss H.L., Barber L.B., et al. Antidepressant pharmaceuticals in two U.S. effluent-impacted streams: occurrence and fate in water and sediment, and selective uptake in fish neural tissue. Environ Sci Technol 2010, 44(6):1918-1925. [Internet, Mar 15 Available from: http://www.ncbi.nlm.nih.gov/pubmed/20121081].
42. Schultz M.M., Painter M.M., Bartell S.E., Logue A., Furlong E.T., Werner S.L., et al. Selective uptake and biological consequences of environmentally relevant antidepressant pharmaceutical exposures on male fathead minnows. Aquat Toxicol 2011, 104(1-2):38-47. [Internet]. Jul [cited 2013 Oct 23]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/21536011].
43. Silva L.J.G., Lino C.M., Meisel L.M., Pena A. Selective serotonin re-uptake inhibitors (SSRIs) in the aquatic environment: an ecopharmacovigilance approach. Sci Total Environ 2012, 437:185-195. [Internet, Elsevier B.V., Oct 15 [cited 2014 Jan 29]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/22940043].
44. Silva L.J.G., Meisel L.M., Lino C.M., Pena A. Profiling serotonin reuptake inhibitors (SSRIs) in the environment: trends in analytical methodologies. Crit Rev Anal Chem 2014, 44(1):41-67. [Internet, Jan 2 [cited 2014 Apr 4]; Available from: http://www.tandfonline.com/doi/abs/10.1080/10408347.2013.827966].
45. Sousa M.A., Gonçalves C., Cunha E., Hajšlová J., Alpendurada M.F. Cleanup strategies and advantages in the determination of several therapeutic classes of pharmaceuticals in wastewater samples by SPE-LC-MS/MS. Anal Bioanal Chem 2011, 399(2):807-822. [Internet, Jan [cited 2013 Oct 23]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/20957470].
46. Vasskog T., Berger U., Samuelsen P.-J., Kallenborn R., Jensen E. Selective serotonin reuptake inhibitors in sewage influents and effluents from Tromsø, Norway. J Chromatogr A 2006, 1115(1-2):187-195. [Internet, May 19 [cited 2013 Oct 23]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/16574138].
47. Vasskog T., Anderssen T., Pedersen-Bjergaard S., Kallenborn R., Jensen E. Occurrence of selective serotonin reuptake inhibitors in sewage and receiving waters at Spitsbergen and in Norway. J Chromatogr A 2008, 1185(2):194-205. [Internet, Mar 28 [cited 2013 Oct 23]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/18280486].
48. Vazquez-Roig P., Andreu V., Onghena M., Blasco C., Picó Y. Assessment of the occurrence and distribution of pharmaceuticals in a Mediterranean wetland (L'Albufera, Valencia, Spain) by LC-MS/MS. Anal Bioanal Chem 2011, 400(5):1287-1301. [Internet, May [cited 2013 Oct 23]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/21416164].
49. Vazquez-Roig P., Andreu V., Blasco C., Picó Y. Risk assessment on the presence of pharmaceuticals in sediments, soils and waters of the Pego-Oliva Marshlands (Valencia, eastern Spain). Sci Total Environ 2012, 440:24-32. [Internet, Elsevier B.V.; Dec 1 [cited 2013 Oct 23]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/23021792].
50. Verlicchi P., Al Aukidy M., Zambello E. Occurrence of pharmaceutical compounds in urban wastewater: removal, mass load and environmental risk after a secondary treatment-a review. Sci Total Environ 2012, 429:123-155. [Internet, Elsevier B.V.;Jul 1 [cited 2013 Oct 23]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/22583809].
51. Vieno N.M., Tuhkanen T., Kronberg L. Seasonal variation in the occurrence of pharmaceuticals in effluents from a sewage treatment plant and in the recipient water. Environ Sci Technol 2005, 39(21):8220-8226. [Internet]. Nov 1Available from: http://www.ncbi.nlm.nih.gov/pubmed/16294858.
52. Wick A., Fink G., Joss A., Siegrist H., Ternes T.A. Fate of beta blockers and psycho-active drugs in conventional wastewater treatment. Water Res 2009, 43(4):1060-1074. [Internet, Elsevier Ltd; Mar [cited 2013 Oct 17]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/19111329].