Source characterization of nervous system active pharmaceutical ingredients in healthcare facility wastewaters

Journal of Environmental Management

Volumn 92, Issue 3, 2011, Pages 872-877

  Nagarnaik, Pranav ^a   Batt, Angela ^b   Boulanger, Bryan ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Active pharmaceutical ingredients; Healthcare facilities; Mass loadings; Nervous system; Risk management; Wastewater

Indexed keywords

ASSISTED LIVING; HOSPITALS; LOADING; NURSING;

ACTIVE PHARMACEUTICALS INGREDIENTS; ALPRAZOLAM; ANALYTES; HEALTHCARE FACILITY; INDEPENDENT LIVING; MASS LOADINGS; OPIOIDS; RISKS MANAGEMENT; SOURCE CHARACTERIZATION; TOTAL MASS;

RISK MANAGEMENT;

ALPRAZOLAM; AMITRIPTYLINE; ANTIDEPRESSANT AGENT; OPIATE;

CONCENTRATION (COMPOSITION); DRUG; HEALTH SERVICES; HOSPITAL SECTOR; METABOLITE; NERVOUS SYSTEM; POLLUTION MONITORING; RISK FACTOR; WASTEWATER;

ARTICLE; ASSISTED LIVING FACILITY; FLOW RATE; HEALTH CARE FACILITY; HOSPITAL; NERVOUS SYSTEM; NURSING; SEWAGE TREATMENT; WASTE COMPONENT REMOVAL;

APIS;

EID: 78650522971     PISSN: 03014797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jenvman.2010.10.058     Document Type: Article

References (33)

1. Barnes K.K., Kolpin D.W., Furlong E.T., Zaugg S.D., Meyer M.T., Barber L.B. A national reconnaissance of pharmaceuticals and other organic wastewater contaminants in the United States - I groundwater. Science of the Total Environment 2008, 402:192-200.
2. Batt A.L., Kostich M.S., Lazorchak J.M. Analysis of ecologically relevant pharmaceuticals in wastewater and surface water using selective solid-phase extraction and UPLC/MS/MS. Analytical Chemistry 2008, 80:5021-5030.
3. Boles T.H., Wells M.J. Analysis of amphetamine and methamphetamine as emerging pollutants in wastewater and wastewater-impacted streams. Journal of Chromatography A 2010, 1217:2561-2568.
4. Breyer-Pfaff U. The metabolic fate of amitriptyline, nortriptyline and amitriptylinoxide in man. Drug Metabolism Reviews 2004, 36:723-746.
5. Brown K.D., Kulis J., Thomson B., Chapman T.H., Mawhinney D.B. Occurrence of antibiotics in hospital, residential, and dairy effluent, municipal wastewater, and the Rio Grande in New Mexico. Science of the Total Environment 2006, 366:772-783.
6. Chiaia A.C., Banta-Green C., Field J. Eliminating solid phase extraction with large-volume injection LC/MS/MS: analysis of illicit and legal drugs and human urine indicators in US wastewaters. Environmental Science & Technology 2008, 42:8841-8848.
7. Focazio M.J., Kolpin D.W., Barnes K.K., Furlong E.T., Meyer M.T., Zaugg S.D., Barber L.B., Thurman M.E. A national reconnaissance for pharmaceuticals and other organic wastewater contaminants in the United States - II Untreated drinking water sources. Science of the Total Environment 2008, 402:201-216.
8. Gomez M.J., Aguera A., Mezcua M., Hurtado J., Mocholi F., Fernandez-Alba A.R. Simultaneous analysis of neutral and acidic pharmaceuticals as well as related compounds by gas chromatography-tandem mass spectrometry in wastewater. Talanta 2007, 73:314-320.
9. Gomez M.J., Malato O., Ferrer I., Aguera A., Fernandez-Alba A.R. Solid-phase extraction followed by liquid chromatography-time-of-flight-mass spectrometry to evaluate pharmaceuticals in effluents. A pilot monitoring study. Journal of Environmental Monitoring 2007, 9:718-729.
10. Gómez M.J., Petrovic M., Fernández-Alba A.R., Barceló D. Determination of pharmaceuticals of various therapeutic classes by solid-phase extraction and liquid chromatography-tandem mass spectrometry analysis in hospital effluent wastewaters. Journal of Chromatography A 2006, 1114:224-233.
11. Hai A., Kümmerer K. Biodegradability of the X-ray contrast compound diatrizoic acid, identification of aerobic degradation products and effects against sewage sludge micro-organisms. Chemosphere 2006, 62:294-302.
12. Heberer T., Feldmann D. Contribution of effluents from hospitals and private households to the total loads of diclofenac and carbamazepine in municipal sewage effluents-modeling versus measurements. Journal of Hazardous Materials 2005, 122:211-218.
13. Heberer T., Reddersen K., Mechlinski A. From municipal sewage to drinking water: fate and removal of pharmaceutical residues in the aquatic environment in urban areas. Water Science and Technology 2002, 46:81-88.
14. IMS Health Incorporated Channel Distribution by US Sales 2007, Channel Distribution by Sales.pdf, [last accessed 27.05.10]. http://imshealth.com/vgn/images/portal/CIT_40000873/39/54/834329792007.
15. Kasprzyk-Hordern B., Dinsdale R.M., Guwy A.J. The removal of pharmaceuticals, personal care products, endocrine disruptors and illicit drugs during wastewater treatment and its impact on the quality of receiving waters. Water Research 2009, 43:363-380.
16. Kasprzyk-Hordern B., Kondakal V.V.R., Baker D.R. Enantiomeric analysis of drugs of abuse in wastewater by chiral liquid chromatography coupled with tandem mass spectrometry. Journal of Chromatography A 2010, 1217:4575-4586.
17. Kolpin D.W., Furlong E.T., Meyer M.T., Thurman E.M., Zaugg S.D., Barber L.B., Buxton H.T. Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S. streams, 1999-2000: a national reconnaissance. Environmental Science & Technology 2002, 36:1202-1211.
18. Kümmerer K. Drugs in the environment: emission of drugs, diagnostic aids and disinfectants into wastewater by hospitals in relation to other sources - a review. Chemosphere 2001, 45:957-969.
19. Lajeunesse A., Gagnon C. Determination of acidic pharmaceutical products and carbamazepine in roughly primary-treated wastewater by solid-phase extraction and gas chromatography-tandem mass spectrometry. International Journal of Environmental Analytical Chemistry 2007, 87:565-578.
20. Lajeunesse A., Gagnon C., SauveÌ S. Determination of basic antidepressants and their N-desmethyl metabolites in raw sewage and wastewater using solid-phase extraction and liquid chromatography-tandem mass spectrometry. Analytical Chemistry 2008, 80:5325-5333.
21. Langford K.H., Thomas K.V. Determination of pharmaceutical compounds in hospital effluents and their contribution to wastewater treatment works. Environment International 2009, 35:766-770.
22. Lenz K., Mahnik S.N., Weissenbacher N., Mader R.M., Kren P., Hann S., Koellensperger G., Uhl M., Knasmuller S., Ferk F., Bursch W., Fuerhacker M. Monitoring, removal and risk assessment of cytostatic drugs in hospital wastewater. Water Science and Technology 2007, 56:141-149.
23. Liu X., Zhang J., Yin J., Duan H., Wu Y., Shao B. Analysis of hormone antagonists in clinical and municipal wastewater by isotopic dilution liquid chromatography tandem mass spectrometry. Analytical and Bioanalytical Chemistry 2010, 396:2977-2985.
24. Metcalfe C.D., Chu S., Judt C., Li H., Oakes K.D., Servos M.R., Andrews D.M. Antidepressants and their metabolites in municipal wastewater, and downstream exposure in an urban watershed. Environmental Toxicology and Chemistry 2010, 29:79-89.
25. Miao X.-S., Metcalfe C.D. Determination of carbamazepine and its metabolites in aqueous samples using liquid chromatography-electrospray tandem mass spectrometry. Analytical Chemistry 2003, 75:3731-3738.
26. NAICS. Health Care and Social Assistance. , [last accessed 27.05.10]. http://www.naics.com/naics62.htm.
27. Office of National Drug Control Policy. Proper Disposal of Prescription Drugs. , [last accessed 27.05.10]. http://staging.whitehousedrugpolicy.gov/drugfact/factsht/proper_disposal.html.
28. Ramirez A.J., Brain R.A., Usenko S., Mottaleb M.A., O'Donnell J.G., Stahl L.L., Wathen J.B., Snyder B.D., Pitt J.L., Perez-Hurtado P., Dobbins L.L., Brooks B.W., Chambliss C.K. Occurrence of pharmaceuticals and personal care products in fish: results of a national pilot study in the United States. Environmental Toxicology and Chemistry 2009, 28:2587-2597.
29. Sim W.-J., Lee J.-W., Oh J.-E. Occurrence and fate of pharmaceuticals in wastewater treatment plants and rivers in Korea. Environmental Pollution 2009, 158:1938-1947.
30. Ternes T.A. Analytical methods for the determination of pharmaceuticals in aqueous environmental samples. TrAC Trends in Analytical Chemistry 2001, 20:419-434.
31. Thomas K.V., Dye C., Schlabach M., Langford K.H. Source to sink tracking of selected human pharmaceuticals from two Oslo city hospitals and a wastewater treatment works. Journal of Environmental Monitoring 2007, 9:1410-1418.
32. van Nuijs A.L.N., Tarcomnicu I., Bervoets L., Blust R., Jorens P.G., Neels H., Covaci A. Analysis of drugs of abuse in wastewater by hydrophilic interaction liquid chromatography-tandem mass spectrometry. Analytical and Bioanalytical Chemistry 2009, 395:819-828.
33. Vasskog T., Anderssen T., Pedersen-Bjergaard S., Kallenborn R., Jensen E. Occurrence of selective serotonin reuptake inhibitors in sewage and receiving waters at Spitsbergen and in Norway. Journal of Chromatography A 2008, 1185:194-205.