Akt pathway protein expression in gastrointestinal Kaposi sarcomas: Relevance for tumor biology

APMIS

Volumn 122, Issue 6, 2014, Pages 518-525

  Badescu, Alina ^a,b   Couvelard, Anne ^c   Handra Luca, Adriana ^a  

^a UNIVERSITÉ PARIS 13   (France)

^b Facultates de Medicina   (Romania)

^c UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Gastrointestinal; Kaposi sarcoma; Signaling; Tumorigenesis

Indexed keywords

HEMOSIDERIN; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B;

ADULT; AGED; ARTICLE; CANCER MORPHOLOGY; CELL PROLIFERATION; CLINICAL ARTICLE; CORRELATION ANALYSIS; CYTOMEGALOVIRUS INFECTION; DIGESTIVE SYSTEM CANCER; EPITHELIUM HYPERPLASIA; ERYTHROCYTE; EXTRACELLULAR MATRIX; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; KAPOSI SARCOMA; MALE; MIXED INFECTION; NEUTROPHIL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPINDLE CELL;

GASTROINTESTINAL; KAPOSI SARCOMA; SIGNALING; TUMORIGENESIS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADULT; AGED; ENDOTHELIUM, VASCULAR; FEMALE; GASTROINTESTINAL NEOPLASMS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; PHOSPHOPROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; SARCOMA, KAPOSI; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TUMOR MARKERS, BIOLOGICAL;

EID: 84901228149     PISSN: 09034641     EISSN: 16000463     Source Type: Journal    
DOI: 10.1111/apm.12190     Document Type: Article

References (34)

1. International Agency for Research on Cancer. Pathology and Genetics of Tumors of the Digestive System World Health Organization Classification of Tumors. Lyon: IARC Press, 2000.
2. Fenoglio-Preiser CM, Noffsinger AE, Stemmermann GN, Lantz PE, Isaacson PG. Gastrointestinal Pathology: An Atlas and Text, 3rd edn. Philadelphia: Lippincott Williams and Wilkin, 2007.
3. Rosai J. Rosai and Ackerman's Surgical Pathology, 10th edn. Philadelphia: Elsevier Mosby, 2011.
4. Chakib A, Hliwa W, Marih L, Himmich H. Maladie de Kaposi au cours de l'infection par le VIH au Maroc. (À propos de 50 cas). Bull Soc Pathol Exot 2003;96:86-9.
5. Rivero Fernández M, García Martos M, Sanz Moya P, Vázquez Romero M, Fernández Amago MT, García Benayas MT, et al. Kaposi's sarcoma with colorectal and anal canal involvement. Gastroenterol Hepatol 2010;33:508-11.
6. Hashimoto H, Müller H, Falk S, Stutte HJ. Histogenesis of Kaposi's sarcoma associated with AIDS: a histologic, immunohistochemical and enzyme histochemical study. Pathol Res Pract 1987;182:658-68.
7. Kadakia SC, Kadakia AS, Westphal MKW. Gastrointestinal Kaposi 's sarcoma as the first manifestation of Acquired Immunodeficiency Syndrome. South Med J 1992;85:37-9.
8. Kahl P, Buettner R, Friedrichs N, Merkelbach-Bruse S, Wenzel J, Heukamp LC. Kaposi's sarcoma of the gastrointestinal tract: report of two cases and review of the literature. Pathol Res Pract 2007;203:227-31.
9. Lemlich G, Schwam L, Lebwohl M. Kaposi's sarcoma and acquired immunodeficiency syndrome Postmortem findings in twenty-four cases. J Am Acad Dermatol 1987;16:319-25.
10. Lim SG, Lipman MC, Squire S, Pillay D, Gillespie S, Sankey EA, et al. Audit of endoscopic surveillance biopsy specimens in HIV positive patients with gastrointestinal Symptoms. Gut 1993;34:1429-32.
11. Orenstein JM, Dieterich DT. The Histopathology of 103 Consecutive Colonoscopy Biopsies From 82 Symptomatic Patients With Acquired Immunodeficiency Syndrome Original and Look-Back Diagnoses. Arch Pathol Lab Med 2001;125:1042-6.
12. Parfitt JR, Rodriguez-Justo M, Feakins R, Novelli MR. Gastrointestinal Kaposi's sarcoma: CD117 expression and the potential for misdiagnosis as gastrointestinal stromal tumor. Histopathology 2008;52:816-23.
13. Penin RM, Fernandez-Figueras MT, Puig L, Rex J, Ferrandiz C, Ariza A. Over-expression of p45(SKP2) in Kaposi's sarcoma correlates with higher tumor stage and extracutaneous involvement but is not directly related to p27(KIP1) down-regulation. Mod Pathol 2002;15:1227-35.
14. Rossi G, Sartori G, Rusev BC, Sgambato A. Expression and molecular analysis of c-kit and PDGFRs in Kaposi's sarcoma of different stages and epidemiological settings. Histopathology 2009;54:619-22.
15. Sanchez del Monte J, Hernandez Guerrero A, Sobrino Cossio S, Lárraga Octavio A, Sánchez Benítez G, López Blanco P, et al. Manifestaciones clinicas y caracteristicas endoscopicas del sarcoma Kaposi en pacientes con sindrome de inmunodeficiencia adquirida. Rev Gastroenterol Mex 2005;70:416-23.
16. Stebbing J, Mazhar D, Lewis R, Palmieri C, Hatzimichael E, Nelson M, et al. The presentation and survival of patients with non-cutaneous AIDS-associated Kaposi's sarcoma. Ann Oncol 2006;17:503-6.
17. Wall SD, Ominsky S, Altman DF, Perkins CL, Sollitto R, Goldberg HI, et al. Multifocal abnormalities of the gastrointestinal tract in AIDS. AJR Am J Roentgenol 1986;146:1-5.
18. Ioachim HL, Adsay V, Giancotti FR, Dorsett B, Melamed J. Kaposi's sarcoma of internal organs. A multiparameter study of 86 cases. Cancer 1995;75:1376-85.
19. Montaner S. Akt/TSC/mTOR activation by the KSHV G protein-coupled receptor emerging insights into the molecular oncogenesis and treatment of Kaposi's sarcoma. Cell Cycle 2007;6:438-43.
20. Jham BC, Ma T, Hu J, Chaisuparat R, Friedman ER, Pandolfi PP, et al. Amplification of the angiogenic signal through the activation of the TSC/mTOR/HIF axis by the KSHV vGPCR in Kaposi's sarcoma. PLoS ONE 2011;6:e19103.
21. Tamburini J, Grimaldi D, Chiche JD, Bricaire F, Bossi P. Cytokine pattern in Kaposi's sarcoma associated with immune restoration disease in HIV and tuberculosis co-infected patients. AIDS 2007;21:1980-3.
22. Sodhi A, Montaner S, Patel V, Gómez-Román JJ, Li Y, Sausville EA, et al. Akt plays a central role in sarcomagenesis induced by Kaposi's sarcoma herpesvirus-encoded G protein-coupled receptor. Proc Natl Acad Sci USA 2004;101:4821-6.
23. Yarchoan R. Key role for a viral lytic gene in Kaposi's sarcoma. N Engl J Med 2006;355:1383-5.
24. Cornali E, Zietz C, Benelli R, Weninger W, Masiello L, Breier G, et al. Vascular endothelial growth factor regulates angiogenesis and vascular permeability in Kaposi's sarcoma. Am J Pathol 1996;149:1851-69.
25. Ho CM, Huang SF, Hu RH, Ho MC, Wu YM, Lee PH. Sirolimus induced signaling modifications in Kaposi's sarcoma with resolution in a liver transplant recipient. Clin Transplant 2010;24:127-32.
26. Dezube BJ, Sullivan R, Koon HB. Emerging targets and novel strategies in the treatment of AIDS-related Kaposi's sarcoma: bidirectional translational Science. J Cell Physiol 2006;209:659-62.
27. Leu HJ, Odermatt B. Multicentric angiosarcoma (Kaposi's sarcoma). Light and electron microscopic and immunohistological findings of idiopathic cases in Europe and Africa and of cases associated with AIDS. Virchows Arch A Pathol Anat Histopathol 1985;408:29-41.
28. Schmid AH. Kaposi's 'sarcoma'-a tumor of vascular origin? Vasa 1973;2:207-14.
29. Parapuram SK, Shi-wen X, Elliott C, Welch ID, Jones H, Baron M, et al. Loss of PTEN expression by dermal fibroblasts causes skin fibrosis. J Invest Dermatol 2011;131:1996-2003.
30. Braunstein S, Karpisheva K, Pola C, Goldberg J, Hochman T, Yee H, et al. A hypoxia-controlled cap-dependent to cap-independent translation switch in breast cancer. Mol Cell 2007;28:501-12.
31. Lahat G, Dhuka AR, Hallevi H, Xiao L, Zou C, Smith KD, et al. Angiosarcoma: clinical and molecular insights. Ann Surg 2010;251:1098-106.
32. Dowling RJ, Topisirovic I, Alain T, Bidinosti M, Fonseca BD, Petroulakis E, et al. mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs. Science 2010;328:1172-6.
33. Nagata N, Iizuka T, Oka S. Gastrointestinal: Kaposi's sarcoma coexistent with cytomegalovirus (CMV) infection. J Gastroenterol Hepatol 2011;26:1340.
34. Kudchodkar SB, Yu Y, Maguire TG, Alwine JC. Human cytomegalovirus infection alters the substrate specificities and rapamycin sensitivities of raptor- and rictor-containing complexes. Proc Natl Acad Sci USA 2006;103:14182-7.