FAAH inhibition enhances anandamide mediated anti-tumorigenic effects in non-small cell lung cancer by downregulating the EGF/EGFR pathway

Oncotarget

Volumn 5, Issue 9, 2014, Pages 2475-2486

  Ravi, Janani ^a   Sneh, Amita ^a   Shilo, Konstantin ^a   Nasser, Mohd W ^a   Ganju, Ramesh K ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

EGFR; FAAH; Met F AEA; NSCLC

Indexed keywords

CANNABINOID 1 RECEPTOR; CASPASE 9; CYCLIN D1; CYCLIN DEPENDENT KINASE 4; CYCLOHEXYLCARBAMIC ACID 3' CARBAMOYLBIPHENYL 3 YL ESTER; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; FATTY ACID AMIDASE; GELATINASE A; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; METHANANDAMIDE; MITOGEN ACTIVATED PROTEIN KINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN KINASE B; AMIDASE; AMIDE; ANANDAMIDE; ARACHIDONIC ACID DERIVATIVE; CALCIUM CHANNEL BLOCKING AGENT; EGFR PROTEIN, HUMAN; ENDOCANNABINOID; FATTY-ACID AMIDE HYDROLASE; MESSENGER RNA; SMALL INTERFERING RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL PROLIFERATION; CHEMOTAXIS; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DOWN REGULATION; DRUG POTENTIATION; DRUG TARGETING; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME RELEASE; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LUNG ADENOCARCINOMA; LUNG CANCER CELL LINE; LUNG NON SMALL CELL CANCER; MALE; MONOTHERAPY; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STRESS FIBER; ADENOCARCINOMA; ANIMAL; ANTAGONISTS AND INHIBITORS; CARCINOMA, NON-SMALL-CELL LUNG; CELL ADHESION; CELL CYCLE; CELL MOTION; DRUG EFFECTS; DRUG RESISTANCE; DRUG SCREENING; ENZYME IMMUNOASSAY; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; LUNG NEOPLASMS; METABOLISM; NUDE MOUSE; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE MICROARRAY; TUMOR CELL CULTURE; WESTERN BLOTTING; WOUND HEALING;

ADENOCARCINOMA; AMIDOHYDROLASES; ANIMALS; APOPTOSIS; ARACHIDONIC ACIDS; BLOTTING, WESTERN; CALCIUM CHANNEL BLOCKERS; CARCINOMA, NON-SMALL-CELL LUNG; CELL ADHESION; CELL CYCLE; CELL MOVEMENT; CELL PROLIFERATION; CHEMOTAXIS; DRUG RESISTANCE, NEOPLASM; ENDOCANNABINOIDS; EPIDERMAL GROWTH FACTOR; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; IMMUNOENZYME TECHNIQUES; LUNG NEOPLASMS; MALE; MICE; MICE, NUDE; NF-KAPPA B; POLYUNSATURATED ALKAMIDES; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTOR, CANNABINOID, CB1; RECEPTOR, EPIDERMAL GROWTH FACTOR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; TISSUE ARRAY ANALYSIS; TUMOR CELLS, CULTURED; WOUND HEALING; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84901194475     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.1723     Document Type: Article

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