Evaluation of an intragastric challenge model for Shigella dysenteriae 1 in rhesus monkeys (Macaca mulatta) for the pre-clinical assessment of Shigella vaccine formulations

APMIS

Volumn 122, Issue 6, 2014, Pages 463-475

  Islam, Dilara ^a   Ruamsap, Nattaya ^a   Khantapura, Patchariya ^a   Aksomboon, Ajchara ^a   Srijan, Apichai ^a   Wongstitwilairoong, Boonchai ^a   Bodhidatta, Ladaporn ^a   Gettayacamin, Montip ^a   Venkatesan, Malabi M ^b   Mason, Carl J ^a  

^a ARMED FORCES RESEARCH INSTITUTE OF MEDICAL SCIENCES   (Thailand)

^b WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

Author keywords

Challenge model; Rhesus monkey (Macaca mulatta); Shigellosis

Indexed keywords

CIPROFLOXACIN; GAMMA INTERFERON; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; SHIGELLA VACCINE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC THERAPY; ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; CELL ASSAY; CELLULAR IMMUNITY; CLINICAL ASSESSMENT; CLINICAL EVALUATION; COLON BIOPSY; COLONY FORMING UNIT; CYTOKINE RESPONSE; DISEASE SEVERITY; DRUG FORMULATION; DYSENTERY; ENDOSCOPIC BIOPSY; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME LINKED IMMUNOSPOT ASSAY; EOSINOPHILIA; FECES CULTURE; GASTROINTESTINAL SYMPTOM; HISTOPATHOLOGY; HUMORAL IMMUNITY; IMMUNE RESPONSE; LEUKOCYTE; LOOSE FECES; LYMPHOCYTOSIS; NEUTROPHILIA; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REINFECTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHESUS MONKEY; SHIGELLA DYSENTERIAE; SHIGELLOSIS; VIRUS CULTURE;

CHALLENGE MODEL; RHESUS MONKEY (MACACA MULATTA); SHIGELLOSIS;

ANIMALS; ANTIBODIES, BACTERIAL; ANTIBODY-PRODUCING CELLS; BACTERIAL LOAD; COLON; CYTOKINES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; DYSENTERY, BACILLARY; FECES; FEMALE; HUMANS; IMMUNOGLOBULIN A, SECRETORY; MACACA MULATTA; MALE; SHIGELLA DYSENTERIAE; SHIGELLA VACCINES; STOMACH;

EID: 84901193170     PISSN: 09034641     EISSN: 16000463     Source Type: Journal    
DOI: 10.1111/apm.12168     Document Type: Article

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