RUNX1 point mutations potentially identify a subset of early immature T-cell acute lymphoblastic leukaemia that may originate from differentiated T-cells

Gene

Volumn 545, Issue 1, 2014, Pages 111-116

  Mok, Michelle Meng Huang ^a   Du, Linsen ^a   Wang, Chelsia Qiuxia ^a,b   Tergaonkar, Vinay ^b   Liu, Te Chih ^c   Yin Kham, Shirley Kow ^d   Sanda, Takaomi ^a   Yeoh, Allen Eng Juh ^d   Osato, Motomi ^a,e  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

^c NATIONAL UNIVERSITY HOSPITAL   (Singapore)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^e INSTITUTE OF BIOENGINEERING AND NANOTECHNOLOGY   (Singapore)

Author keywords

AML1; Early immature T ALL; ETP ALL; RUNX1; TCR deletion

Indexed keywords

TRANSCRIPTION FACTOR RUNX1; RUNX1 PROTEIN, HUMAN;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; AMPLICON; ARTICLE; CANCER PATIENT; CELL DIFFERENTIATION; CHILD; FEMALE; GENE SEQUENCE; HUMAN; HUMAN CELL; LEUKEMIA CELL; MAJOR CLINICAL STUDY; MALE; POINT MUTATION; PRIORITY JOURNAL; T LYMPHOCYTE; GENE DELETION; GENETICS; PATHOLOGY; PRESCHOOL CHILD; T LYMPHOCYTE RECEPTOR GENE; TUMOR CELL LINE; YOUNG ADULT;

ADOLESCENT; CELL DIFFERENTIATION; CELL LINE, TUMOR; CHILD; CHILD, PRESCHOOL; CORE BINDING FACTOR ALPHA 2 SUBUNIT; FEMALE; GENES, T-CELL RECEPTOR GAMMA; HUMANS; MALE; POINT MUTATION; PRECURSOR T-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; SEQUENCE DELETION; YOUNG ADULT;

EID: 84901192305     PISSN: 03781119     EISSN: 18790038     Source Type: Journal    
DOI: 10.1016/j.gene.2014.04.074     Document Type: Article

References (16)

1. Berquam-Vrieze K., Nannapaneni K., Brett B., Holmfeldt L., Ma J., Zagorodna O., Jenkins N., Copeland N., Meyerholz D., Knudson C., Mullighan C., Scheetz T., Dupuy A. Cell of origin strongly influences genetic selection in a mouse model of T-ALL. Blood 2011, 118:4646-4656.
2. Coustan-Smith E., Mullighan C.G., Onciu M., Behm F.G., Raimondi S.C., Pei D., Cheng C., Su X., Rubnitz J.E., Basso G., Biondi A., Pui C.H., Downing J.R., Campana D. Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia. The Lancet Oncology 2009, 10:147-156.
3. Della Gatta G., Palomero T., Perez-Garcia A., Ambesi-Impiombato A., Bansal M., Carpenter Z.W., De Keersmaecker K., Sole X., Xu L., Paietta E., Racevskis J., Wiernik P.H., Rowe J.M., Meijerink J.P., Califano A., Ferrando A.A. Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL. Nature Medicine 2012, 18:436-440.
4. Grossmann V., Kern W., Harbich S., Alpermann T., Jeromin S., Schnittger S., Haferlach C., Haferlach T., Kohlmann A. Prognostic relevance of RUNX1 mutations in T-cell acute lymphoblastic leukemia. Haematologica 2011, 96:1874-1877.
5. Grossmann V., Haferlach C., Weissmann S., Roller A., Schindela S., Poetzinger F., Stadler K., Bellos F., Kern W., Haferlach T., Schnittger S., Kohlmann A. The molecular profile of adult T-cell acute lymphoblastic leukemia: mutations in RUNX1 and DNMT3A are associated with poor prognosis in T-ALL. Genes, Chromosomes & Cancer 2013, 52:410-422.
6. Gutierrez A., Dahlberg S.E., Neuberg D.S., Zhang J., Grebliunaite R., Sanda T., Protopopov A., Tosello V., Kutok J., Larson R.S., Borowitz M.J., Loh M.L., Ferrando A.A., Winter S.S., Mullighan C.G., Silverman L.B., Chin L., Hunger S.P., Sallan S.E., Look A.T. Absence of biallelic TCRγ deletion predicts early treatment failure in pediatric T-cell acute lymphoblastic leukemia. Journal of Clinical Oncology 2010, 28:3816-3823.
7. Harada H., Harada Y., Niimi H., Kyo T., Kimura A., Inaba T. High incidence of somatic mutations in the AML1/RUNX1 gene in myelodysplastic syndrome and low blast percentage myeloid leukemia with myelodysplasia. Blood 2004, 103:2316-2324.
8. Howcroft T., Weissman J., Gegonne A., Singer D. A T lymphocyte-specific transcription complex containing RUNX1 activates MHC class I expression. Journal of Immunology 2005, 174:2106-2115.
9. Huang G., Zhao X., Wang L., Elf S., Xu H., Zhao X., Sashida G., Zhang Y., Liu Y., Lee J., Menendez S., Yang Y., Yan X., Zhang P., Tenen D., Osato M., Hsieh J., Nimer S. The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations. Blood 2011, 118:6544-6552.
10. Ichikawa M., Asai T., Saito T., Seo S., Yamazaki I., Yamagata T., Mitani K., Chiba S., Ogawa S., Kurokawa M., Hirai H. AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis. Nature Medicine 2004, 10:299-304.
11. Koh C.P., Wang C.Q., Ng C.E.L., Ito Y., Araki M., Tergaonkar V., Huang G., Osato M. RUNX1 meets MLL: epigenetic regulation of hematopoiesis by two leukemia genes. Leukemia 2013, 27:1793-1802.
12. Nishimoto N., Imai Y., Ueda K., Nakagawa M., Shinohara A., Ichikawa M., Nannya Y., Kurokawa M. T cell acute lymphoblastic leukemia arising from familial platelet disorder. International Journal of Hematology 2010, 92:194-197.
13. Osato M. Point mutations in the RUNX1/AML1 gene: another actor in RUNX leukemia. Oncogene 2004, 23:4284-4296.
14. Taketani T., Taki T., Takita J., Tsuchida M., Hanada R., Hongo T., Kaneko T., Manabe A., Ida K., Hayashi Y. AML1/RUNX1 mutations are infrequent, but related to AML-M0, acquired trisomy 21, and leukemic transformation in pediatric hematologic malignancies. Genes, Chromosomes & Cancer 2003, 38:1-7.
15. Taniuchi I., Osato M., Ito Y. Runx1: no longer just for leukemia. The EMBO Journal 2012, 31:1.
16. Zhang J., Ding L., Holmfeldt L., Wu G., Heatley S.L., Payne-Turner D., Easton J., Chen X., Wang J., Rusch M., Lu C., Chen S.-C., Wei L., Collins-Underwood J.R., Ma J., Roberts K.G., Pounds S.B., Ulyanov A., Becksfort J., Gupta P., Huether R., Kriwacki R.W., Parker M., McGoldrick D.J., Zhao D., Alford D., Espy S., Bobba K.C., Song G., Pei D., Cheng C., Roberts S., Barbato M.I., Campana D., Coustan-Smith E., Shurtleff S.A., Raimondi S.C., Kleppe M., Cools J., Shimano K.A., Hermiston M.L., Doulatov S., Eppert K., Laurenti E., Notta F., Dick J.E., Basso G., Hunger S.P., Loh M.L., Devidas M., Wood B., Winter S., Dunsmore K.P., Fulton R.S., Fulton L.L., Hong X., Harris C.C., Dooling D.J., Ochoa K., Johnson K.J., Obenauer J.C., Evans W.E., Pui C.-H., Naeve C.W., Ley T.J., Mardis E.R., Wilson R.K., Downing J.R., Mullighan C.G. The genetic basis of early T-cell precursor acute lymphoblastic leukaemia. Nature 2012, 481:157-163.