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1
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67449131552
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Incremental value of copeptin for rapid rule out of acute myocardial infarction
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Reichlin T, Hochholzer W, Stelzig C, Laule K, Freidank H, Morgenthaler NG, et al. Incremental value of copeptin for rapid rule out of acute myocardial infarction. J Am Coll Cardiol. 2009;54(1):60-8.
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J Am Coll Cardiol
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Reichlin, T.1
Hochholzer, W.2
Stelzig, C.3
Laule, K.4
Freidank, H.5
Morgenthaler, N.G.6
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2
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34547668476
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Copeptin, a stable peptide of the arginine vasopressin precursor, is elevated in hemorrhagic and septic shock
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DOI 10.1097/SHK.0b013e318033e5da, PII 0002438220070800000015
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Morgenthaler NG, Muller B, Struck J, Bergmann A, Redl H, Christ-Crain M. Copeptin, a stable peptide of the arginine vasopressin precursor, is elevated in hemorrhagic and septic shock. Shock. 2007;28(2):219-26. (Pubitemid 47220835)
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Shock
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Morgenthaler, N.G.1
Muller, B.2
Struck, J.3
Bergmann, A.4
Redl, H.5
Christ-Crain, M.6
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3
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84867362492
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Third universal definition ofmyocardial infarction
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Thygesen K, Alpert JS, Jaffe AS, Simoons ML, Chaitman BR, White HD, et al. Third universal definition ofmyocardial infarction. J Am Coll Cardiol. 2012;60(16):1581-98.
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J Am Coll Cardiol
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Thygesen, K.1
Alpert, J.S.2
Jaffe, A.S.3
Simoons, M.L.4
Chaitman, B.R.5
White, H.D.6
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4
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84874941217
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Chief complaints in medical emergencies: Do they relate to underlying disease and outcome?
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The Charité Emergency Medicine Study (CHARITEM). This is an important study emphasizing the clinical need of introducing copeptin testing to the diagnostic workup in patients with ACS, as it shows that symptoms suggestive of ACS are common in the ED, but AMI is diagnosed in only 10-15% of these patients
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• Mockel M, Searle J, Muller R, Slagman A, Storchmann H, Oestereich P, et al. Chief complaints in medical emergencies: do they relate to underlying disease and outcome? The Charité Emergency Medicine Study (CHARITEM). Eur J Emerg Med. 2013;20(2):103-8. This is an important study emphasizing the clinical need of introducing copeptin testing to the diagnostic workup in patients with ACS, as it shows that symptoms suggestive of ACS are common in the ED, but AMI is diagnosed in only 10-15% of these patients.
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(2013)
Eur J Emerg Med
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, pp. 103-108
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Mockel, M.1
Searle, J.2
Muller, R.3
Slagman, A.4
Storchmann, H.5
Oestereich, P.6
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5
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12744279568
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The health care burden of acute chest pain
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Goodacre S, Cross E, Arnold J, Angelini K, Capewell S, Nicholl J. The health care burden of acute chest pain. Heart. 2005;91(2): 229-30.
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(2005)
Heart
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Goodacre, S.1
Cross, E.2
Arnold, J.3
Angelini, K.4
Capewell, S.5
Nicholl, J.6
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7
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84858996807
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Association between waiting times and short term mortality and hospital admission after departure from emergency department: Population based cohort study from Ontario, Canada
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Guttmann A, Schull MJ, Vermeulen MJ, Stukel TA. Association between waiting times and short term mortality and hospital admission after departure from emergency department: population based cohort study from Ontario, Canada. BMJ. 2011;342:d2983.
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BMJ
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Guttmann, A.1
Schull, M.J.2
Vermeulen, M.J.3
Stukel, T.A.4
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8
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77951649887
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Copeptin improves early diagnosis of acutemyocardial infarction
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Keller T, Tzikas S, Zeller T, Czyz E, Lillpopp L, Ojeda FM, et al. Copeptin improves early diagnosis of acutemyocardial infarction. J Am Coll Cardiol. 2010;55(19):2096-106.
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(2010)
J Am Coll Cardiol
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Keller, T.1
Tzikas, S.2
Zeller, T.3
Czyz, E.4
Lillpopp, L.5
Ojeda, F.M.6
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9
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80053405636
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Combined testing of high-sensitivity troponin T and copeptin on presentation at prespecified cutoffs improves rapid rule-out of non-ST-segment elevation myocardial infarction
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This recent study adds evidence to the new rule-out strategy
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• Giannitsis E, Kehayova T, Vafaie M, Katus HA. Combined testing of high-sensitivity troponin T and copeptin on presentation at prespecified cutoffs improves rapid rule-out of non-ST-segment elevation myocardial infarction. Clin Chem. 2011;57(10):1452-5. This recent study adds evidence to the new rule-out strategy.
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(2011)
Clin Chem
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, Issue.10
, pp. 1452-1455
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Giannitsis, E.1
Kehayova, T.2
Vafaie, M.3
Katus, H.A.4
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10
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84858618064
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Diagnostic and prognostic impact of copeptin and high-sensitivity cardiac troponin T in patients with pre-existing coronary artery disease and suspected acute myocardial infarction
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This recent study adds evidence to the new rule-out strategy
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• Potocki M, Reichlin T, Thalmann S, Zellweger C, Twerenbold R, Reiter M, et al. Diagnostic and prognostic impact of copeptin and high-sensitivity cardiac troponin T in patients with pre-existing coronary artery disease and suspected acute myocardial infarction. Heart. 2012;98(7):558-65. This recent study adds evidence to the new rule-out strategy.
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(2012)
Heart
, vol.98
, Issue.7
, pp. 558-565
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Potocki, M.1
Reichlin, T.2
Thalmann, S.3
Zellweger, C.4
Twerenbold, R.5
Reiter, M.6
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11
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84858011180
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Combined copeptin and troponin to rule out myocardial infarction in patients with chest pain and a history of coronary artery disease
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This recent study adds evidence to the new rule-out strategy
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• Ray P, Charpentier S, Chenevier-Gobeaux C, Reichlin T, Twerenbold R, Claessens YE, et al. Combined copeptin and troponin to rule out myocardial infarction in patients with chest pain and a history of coronary artery disease. Am J Emerg Med. 2012;30(3): 440-8. This recent study adds evidence to the new rule-out strategy.
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(2012)
Am J Emerg Med
, vol.30
, Issue.3
, pp. 440-448
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Ray, P.1
Charpentier, S.2
Chenevier-Gobeaux, C.3
Reichlin, T.4
Twerenbold, R.5
Claessens, Y.E.6
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12
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84861309003
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Combination of copeptin and troponin assays to rapidly rule out non-ST elevation myocardial infarction in the emergency department
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This recent study adds evidence to the new rule-out strategy
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• Charpentier S, Maupas-Schwalm F, Cournot M, Elbaz M, Botella JM, Lauque D. Combination of copeptin and troponin assays to rapidly rule out non-ST elevation myocardial infarction in the emergency department. Acad Emerg Med. 2012;19(5):517-24. This recent study adds evidence to the new rule-out strategy.
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(2012)
Acad Emerg Med
, vol.19
, Issue.5
, pp. 517-524
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Charpentier, S.1
Maupas-Schwalm, F.2
Cournot, M.3
Elbaz, M.4
Botella, J.M.5
Lauque, D.6
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13
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84876744807
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Copeptin improves the diagnostic performance of sensitive troponin I-Ultra but cannot rapidly rule out non-ST-elevation myocardial infarction at presentation to an emergency department
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This recent study adds evidence to the new rule-out strategy
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• Charpentier S, Lepage B, Maupas-Schwalm F, Cinq-Frais C, Bichard-Breaud M, Botella JM, et al. Copeptin improves the diagnostic performance of sensitive troponin I-Ultra but cannot rapidly rule out non-ST-elevation myocardial infarction at presentation to an emergency department. Ann Emerg Med. 2013;61(5):549-58. This recent study adds evidence to the new rule-out strategy.
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(2013)
Ann Emerg Med
, vol.61
, Issue.5
, pp. 549-558
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Charpentier, S.1
Lepage, B.2
Maupas-Schwalm, F.3
Cinq-Frais, C.4
Bichard-Breaud, M.5
Botella, J.M.6
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14
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84899984249
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The utility of copeptin in the emergency department for non-STelevation myocardial infarction rapid rule out: COPED-MIRRO study
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doi:10.1097/MEJ.0b013e3283632f8b. This recent study adds evidence to the new rule-out strategy
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• Llorens P, Sanchez M, Herrero P, Martin-Sanchez FJ, Pinera P, Miro O. The utility of copeptin in the emergency department for non-STelevation myocardial infarction rapid rule out: COPED-MIRRO study. Eur J Emerg Med. 2013. doi:10.1097/MEJ.0b013e3283632f8b. This recent study adds evidence to the new rule-out strategy.
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(2013)
Eur J Emerg Med
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Llorens, P.1
Sanchez, M.2
Herrero, P.3
Martin-Sanchez, F.J.4
Pinera, P.5
Miro, O.6
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15
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84891829548
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Comparison of contemporary troponin assays with the novel biomarkers, heart fatty acid binding protein and copeptin, for the early confirmation or exclusion of myocardial infarction in patients presenting to the emergency department with chest pain
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This recent study adds evidence to the new rule-out strategy
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• Collinson P, Gaze D, Goodacre S. Comparison of contemporary troponin assays with the novel biomarkers, heart fatty acid binding protein and copeptin, for the early confirmation or exclusion of myocardial infarction in patients presenting to the emergency department with chest pain. Heart. 2014;100(2):140-5. This recent study adds evidence to the new rule-out strategy.
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(2014)
Heart
, vol.100
, Issue.2
, pp. 140-145
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Collinson, P.1
Gaze, D.2
Goodacre, S.3
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16
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84884818044
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Impact of copeptin on diagnosis, risk stratification, and intermediate-term prognosis of acute coronary syndromes
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This recent study adds evidence to the new rule-out strategy
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• Afzali D, Erren M, PavenstadtHJ, Vollert JO, Hertel S, Waltenberger J, et al. Impact of copeptin on diagnosis, risk stratification, and intermediate-term prognosis of acute coronary syndromes. Clin Res Cardiol. 2013;102(10):755-63. This recent study adds evidence to the new rule-out strategy.
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(2013)
Clin Res Cardiol
, vol.102
, Issue.10
, pp. 755-763
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Afzali, D.1
Erren, M.2
Pavenstadt, H.J.3
Vollert, J.O.4
Hertel, S.5
Waltenberger, J.6
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17
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84899051753
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Diagnostic performance of copeptin in patients with acute nontraumatic chest pain: BWH-TIMI ED Chest Pain Study
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This recent study adds evidence to the new rule-out strategy
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• Sukul D, Bonaca MP, Ruff CT, Kosowsky J, Conrad M, Murphy SA, et al. Diagnostic performance of copeptin in patients with acute nontraumatic chest pain: BWH-TIMI ED Chest Pain Study. Clin Cardiol. 2014;37(4):227-32. This recent study adds evidence to the new rule-out strategy.
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(2014)
Clin Cardiol
, vol.37
, Issue.4
, pp. 227-232
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Sukul, D.1
Bonaca, M.P.2
Ruff, C.T.3
Kosowsky, J.4
Conrad, M.5
Murphy, S.A.6
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18
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84860383231
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High-sensitive cardiac troponin T outperforms novel diagnostic biomarkers in patients with acute chest pain
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This recent study adds evidence to the new rule-out strategy
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• Eggers KM, Venge P, Lindahl B. High-sensitive cardiac troponin T outperforms novel diagnostic biomarkers in patients with acute chest pain. Clin Chim Acta. 2012;413(13-14):1135-40. This recent study adds evidence to the new rule-out strategy.
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(2012)
Clin Chim Acta
, vol.413
, Issue.13-14
, pp. 1135-1140
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Eggers, K.M.1
Venge, P.2
Lindahl, B.3
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19
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84898598586
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Expeditious exclusion of acute coronary syndrome diagnosis by combined measurements of copeptin, highsensitivity troponin, and GRACE score
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This recent multicenter study specifically tested the rule out strategy in subgroups with different pretest probabilities
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•• Bohyn E, Dubie E, Lebrun C, Jund J, Beaune G, Lesage P, et al. Expeditious exclusion of acute coronary syndrome diagnosis by combined measurements of copeptin, highsensitivity troponin, and GRACE score. Am J Emerg Med. 2014;32(4):293-6. This recent multicenter study specifically tested the rule out strategy in subgroups with different pretest probabilities.
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(2014)
Am J Emerg Med
, vol.32
, Issue.4
, pp. 293-296
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Bohyn, E.1
Dubie, E.2
Lebrun, C.3
Jund, J.4
Beaune, G.5
Lesage, P.6
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20
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84877731785
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Copeptin for rapid rule out of acute myocardial infarction in emergency department
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This recent multicenter study emphasizes the importance of pretest probability
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•• Chenevier-Gobeaux C, Freund Y, Claessens YE, Guerin S, Bonnet P, Doumenc B, et al. Copeptin for rapid rule out of acute myocardial infarction in emergency department. Int J Cardiol. 2013;166(1): 198-204. This recent multicenter study emphasizes the importance of pretest probability.
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(2013)
Int J Cardiol
, vol.166
, Issue.1
, pp. 198-204
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Chenevier-Gobeaux, C.1
Freund, Y.2
Claessens, Y.E.3
Guerin, S.4
Bonnet, P.5
Doumenc, B.6
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21
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84858383897
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Biomarkers in acute myocardial injury
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This recent study adds evidence to the new rule-out strategy
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• Kehl DW, Iqbal N, Fard A, Kipper BA, De La Parra LA, Maisel AS. Biomarkers in acute myocardial injury. Transl Res. 2012;159(4): 252-64. This recent study adds evidence to the new rule-out strategy.
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(2012)
Transl Res
, vol.159
, Issue.4
, pp. 252-264
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Kehl, D.W.1
Iqbal, N.2
Fard, A.3
Kipper, B.A.4
De La Parra, L.A.5
Maisel, A.S.6
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22
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84879828614
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Copeptin helps in the early detection of patients with acute myocardial infarction: Primary results of the CHOPIN trial (Copeptin Helps in the early detection Of Patients with acute myocardial INfarction)
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This recent multicenter study emphasizes the importance of pretest probability
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•• Maisel A, Mueller C, Neath SX, Christenson RH, Morgenthaler NG, McCord J, et al. Copeptin helps in the early detection of patients with acute myocardial infarction: primary results of the CHOPIN trial (Copeptin Helps in the early detection Of Patients with acute myocardial INfarction). J Am Coll Cardiol. 2013;62(2):150-60. This recent multicenter study emphasizes the importance of pretest probability.
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(2013)
J Am Coll Cardiol
, vol.62
, Issue.2
, pp. 150-160
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Maisel, A.1
Mueller, C.2
Neath, S.X.3
Christenson, R.H.4
Morgenthaler, N.G.5
McCord, J.6
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23
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84882303038
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Additional diagnostic and prognostic value of copeptin ultra-sensitive for diagnosis of non-ST-elevation myocardial infarction in older patients presenting to the emergency department
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This recent study adds evidence to the new rule-out strategy
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• Bahrmann P, Bahrmann A, Breithardt OA, Daniel WG, Christ M, Sieber CC, et al. Additional diagnostic and prognostic value of copeptin ultra-sensitive for diagnosis of non-ST-elevation myocardial infarction in older patients presenting to the emergency department. Clin Chem Lab Med. 2013;51(6):1307-19. This recent study adds evidence to the new rule-out strategy.
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(2013)
Clin Chem Lab Med
, vol.51
, Issue.6
, pp. 1307-1319
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Bahrmann, P.1
Bahrmann, A.2
Breithardt, O.A.3
Daniel, W.G.4
Christ, M.5
Sieber, C.C.6
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24
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79961087161
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Copeptin does not add diagnostic information to high-sensitivity troponin T in low-to intermediate-risk patients with acute chest pain: Results from the Rule Out Myocardial Infarction by Computed Tomography (ROMICAT) study
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This recent study adds evidence to the new rule-out strategy
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• Karakas M, Januzzi Jr JL, Meyer J, Lee H, Schlett CL, Truong QA, et al. Copeptin does not add diagnostic information to high-sensitivity troponin T in low-to intermediate-risk patients with acute chest pain: results from the Rule Out Myocardial Infarction by Computed Tomography (ROMICAT) study. Clin Chem. 2011;57(8):1137-45. This recent study adds evidence to the new rule-out strategy.
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(2011)
Clin Chem
, vol.57
, Issue.8
, pp. 1137-1145
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Karakas, M.1
Januzzi Jr., J.L.2
Meyer, J.3
Lee, H.4
Schlett, C.L.5
Truong, Q.A.6
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25
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84879056337
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The combination of high sensitivity troponin Tand copeptin facilitates early rule-out of ACS: A prospective observational study
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This recent study adds evidence to the new ruleout strategy
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• Thelin J, Borna C, Erlinge D, Ohlin B. The combination of high sensitivity troponin Tand copeptin facilitates early rule-out of ACS: a prospective observational study. BMC Cardiovasc Disord. 2013;13(1):42. This recent study adds evidence to the new ruleout strategy.
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(2013)
BMC Cardiovasc Disord
, vol.13
, Issue.1
, pp. 42
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Thelin, J.1
Borna, C.2
Erlinge, D.3
Ohlin, B.4
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26
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79251613739
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Combination of copeptin and high-sensitivity cardiac troponin T assay in unstable angina and non-ST-segment elevation myocardial infarction: A pilot study
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This recent study adds evidence to the new rule-out strategy
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• Meune C, Zuily S, Wahbi K, Claessens YE, Weber S, Chenevier-Gobeaux C. Combination of copeptin and high-sensitivity cardiac troponin T assay in unstable angina and non-ST-segment elevation myocardial infarction: a pilot study. Arch Cardiovasc Dis. 2011;104(1):4-10. This recent study adds evidence to the new rule-out strategy.
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(2011)
Arch Cardiovasc Dis
, vol.104
, Issue.1
, pp. 4-10
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Meune, C.1
Zuily, S.2
Wahbi, K.3
Claessens, Y.E.4
Weber, S.5
Chenevier-Gobeaux, C.6
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27
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84883799405
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Early rule out of acute myocardial infarction in ED patients: Value of combined high-sensitivity cardiac troponin T and ultrasensitive copeptin assays at admission
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This recent study adds evidence to the new rule-out strategy
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• Sebbane M, Lefebvre S, Kuster N, Jreige R, Jacques E, Badiou S, et al. Early rule out of acute myocardial infarction in ED patients: value of combined high-sensitivity cardiac troponin T and ultrasensitive copeptin assays at admission. Am J Emerg Med. 2013;31(9): 1302-8. This recent study adds evidence to the new rule-out strategy.
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(2013)
Am J Emerg Med
, vol.31
, Issue.9
, pp. 1302-1308
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Sebbane, M.1
Lefebvre, S.2
Kuster, N.3
Jreige, R.4
Jacques, E.5
Badiou, S.6
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28
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84925480988
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Early discharge using single cardiac troponin and copeptin testing in patients with suspected acute coronary syndrome (ACS): A randomized, controlled clinical process study
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10.1093/eurheartj/ehu178. This actual interventional, randomized process trial, evaluating the early rule-out strategy in clinical practice, has indicated that low-risk to intermediate-risk patients with a negative copeptin-troponin marker combination can be safely discharged
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•• Möckel M, Searle J, Hamm C, Slagman A, Blankenberg S, Huber K, et al. Early discharge using single cardiac troponin and copeptin testing in patients with suspected acute coronary syndrome (ACS): a randomized, controlled clinical process study European Heart Journal 2014. 10.1093/eurheartj/ehu178. This actual interventional, randomized process trial, evaluating the early rule-out strategy in clinical practice, has indicated that low-risk to intermediate-risk patients with a negative copeptin-troponin marker combination can be safely discharged.
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European Heart Journal 2014
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Möckel, M.1
Searle, J.2
Hamm, C.3
Slagman, A.4
Blankenberg, S.5
Huber, K.6
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