K-Map: Connecting kinases with therapeutics for drug repurposing and development

Human Genomics

Volumn 7, Issue 1, 2013, Pages

  Kim, Jihye ^a   Yoo, Minjae ^a   Kang, Jaewoo ^b   Tan, Aik Choon ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b Korea University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOTRANSFERASE; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN KINASE;

ARTICLE; DRUG REPOSITIONING; INTERNET; K MAP; QUANTITATIVE ANALYSIS; REFERENCE DATABASE; BIOLOGY; COMPUTER PROGRAM; GENETICS; HUMAN; METABOLISM; METHODOLOGY; MUTATION; THEORETICAL MODEL;

COMPUTATIONAL BIOLOGY; DRUG REPOSITIONING; HUMANS; INTERNET; MODELS, THEORETICAL; MUTATION; PROTEIN KINASES; SOFTWARE;

EID: 84901068489     PISSN: 14739542     EISSN: 14797364     Source Type: Journal    
DOI: 10.1186/1479-7364-7-20     Document Type: Article

References (13)

1. Cohen P: Protein kinases - the major drug targets of the twenty-first century. Nat Rev Drug Discov 2002, 1(4):309-315. (Pubitemid 37361447)
2. Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S: The protein kinase complement of the human genome. Science 2002, 298(5600):1912-1934. (Pubitemid 35425239)
3. Druker BJ, Talpaz M, Resta DJ, Peng B, Buchdunger E, Ford JM, Lydon NB, Kantarjian H, Capdeville R, Ohno-Jones S, Sawyers CL: Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med 2001, 344:1031-1037. (Pubitemid 32267972)
4. Demetri GD, von Mehren M, Blanke CD, Van den Abbeele AD, Eisenberg B, Roberts PJ, Heinrich MC, Tuveson DA, Singer S, Janicek M, Fletcher JA, Silverman SG, Silberman SL, Capdeville R, Kiese B, Peng B, Dimitrijevic S, Druker BJ, Corless C, Fletcher CD, Joensuu H: Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med 2002, 347:472-480. (Pubitemid 34879334)
5. Lamb J, Crawford ED, Peck D, Modell JW, Blat IC, Wrobel MJ, Lerner J, Brunet JP, Subramanian A, Ross KN, Reich M, Hieronymus H, Wei G, Armstrong SA, Haggarty SJ, Clemons PA, Wei R, Carr SA, Lander ES, Golub TR: The connectivity map: using gene-expression signatures to connect small molecules, genes and disease. Science 2006, 131(5795):1929-1935. (Pubitemid 44497995)
6. Anastassiadis T, Deacon SW, Devarajan K, Ma H, Peterson JR: Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. Nat Biotechnol 2011, 29(11):1039-1045.
7. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP: Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol 2011, 29(11):1046-1051.
8. Bolton E, Wang Y, Thiessen PA, Bryant SH: PubChem: Integrated platform of small molecules and biological activities. In Annual Reports in Computational Chemistry. 4th edition. Washington, DC: American Chemical Society; 2008.
9. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP: ChEMBL: a large-scale bioactivity database for chemical biology and drug discovery. Nucleic Acids Res 2011, 40(Database issue):D1100-1107.
10. Kanehisa M, Goto S, Sato Y, Furumichi M, Tanabe M: KEGG for integration and interpretation of large-scale molecular datasets. Nucleic Acids Res 2012, 40:D109-D114.
11. Yang M, Soares J, Greninger P, Edelman EJ, Lightfoot H, Forbes S, Bindal N, Beare D, Smith JA, Thompson IR, Ramaswamy S, Futreal PA, Haber DA, Stratton MR, Benes C, McDermott U, Garnett MJ: Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells. Nucleic Acids Res 2013, 41(Database issue):D955-961.
12. O'boyle NM, Banck M, James CA, Morley C, Vandermeersch T, Hutchison GR: Open Babel: an open chemical toolbox. J Cheminform 2011, 3:33.
13. Sullivan KD, Padilla-Just N, Henry RE, Porter CC, Kim J, Tentler JJ, Eckhardt SG, Tan AC, DeGregori J, Espinosa JM: ATM and MET kinases are synthetic lethal with nongenotoxic activation of p53. Nat Chem Biol 2012, 8(7):646-654.