Stability of DNA methylation patterns in mouse spermatogonia under conditions of MTHFR deficiency and methionine supplementation

Biology of Reproduction

Volumn 89, Issue 5, 2013, Pages

  Garner, Justine L ^a,b   Niles, Kirsten M ^a,b   McGraw, Serge ^a,b   Yeh, Jonathan R ^a,b   Cushnie, Duncan W ^a,b   Hermo, Louis ^b   Nagano, Makoto C ^a,b   Trasler, Jacquetta M ^a,b  

^a RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

Cell culture; DNA methylation; Epigenetics; MTHFR; Spermatogonia; Spermatogonial stem cells

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); DNA; FOLIC ACID; METHIONINE;

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CULTURE; CELL ISOLATION; CHROMOSOME 9; CONTROLLED STUDY; DNA METHYLATION; DNA POLYMORPHISM; ENZYME ACTIVITY; ENZYME DEFICIENCY; FLOW CYTOMETRY; GENETIC VARIABILITY; GERM CELL; IMMUNOHISTOCHEMISTRY; MALE; MALE INFERTILITY; MOUSE; NONHUMAN; PRIMORDIAL GERM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PYROSEQUENCING; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SERTOLI CELL; SPERMATOCYTE; SPERMATOGONIUM; WESTERN BLOTTING; WILD TYPE;

CELL CULTURE; DNA METHYLATION; EPIGENETICS; MTHFR; SPERMATOGONIA; SPERMATOGONIAL STEM CELLS;

ADULT STEM CELLS; ANIMALS; ANIMALS, NEWBORN; CELLS, CULTURED; DIETARY SUPPLEMENTS; DNA METHYLATION; FEMALE; GENOMIC INSTABILITY; HOMOCYSTINURIA; MALE; METHIONINE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, TRANSGENIC; MUSCLE SPASTICITY; PSYCHOTIC DISORDERS; SPERMATOGONIA;

EID: 84901064616     PISSN: 00063363     EISSN: 15297268     Source Type: Journal    
DOI: 10.1095/biolreprod.113.109066     Document Type: Article

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