Adverse effects of 5-aza-2′-deoxycytidine on spermatogenesis include reduced sperm function and selective inhibition of de novo DNA methylation

Journal of Pharmacology and Experimental Therapeutics

Volumn 322, Issue 3, 2007, Pages 1171-1180

  Oakes, Christopher C ^a,b   Kelly, Tamara L J ^a,b   Robaire, Bernard ^a   Trasler, Jacquetta M ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE;

ANALYTIC METHOD; ARTICLE; BLASTOCYST; CYTOTOXICITY; DNA METHYLATION; DRUG RESPONSE; EMBRYO DEVELOPMENT; FERTILIZATION; GENE LOCUS; GERM CELL; MALE; MALE INFERTILITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REPRODUCTION; RESTRICTION LANDMARK GENOMIC SCANNING; SOUTHERN BLOTTING; SPERM; SPERMATOGENESIS; SPERMATOZOON MOTILITY; SURVIVAL;

ANIMALS; AZACITIDINE; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; GENOTYPE; INFERTILITY, MALE; MALE; MICE; SPERMATOGENESIS; SPERMATOZOA;

EID: 34548058909     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.107.121699     Document Type: Article

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